Inferior vena cava interruption in renal cell carcinoma with tumor thrombus: surgical strategy and perioperative results
Abstract Background To analyze the influence of inferior vena cava (IVC) interruption for perioperative and oncological results in patients with renal cell carcinoma and tumor thrombus and summarize the surgical strategies of IVC interruption for different situations. Methods We retrospectively anal...
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2021
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oai:doaj.org-article:6fca46e29f504acc82409252b69d1b282021-11-28T12:07:30ZInferior vena cava interruption in renal cell carcinoma with tumor thrombus: surgical strategy and perioperative results10.1186/s12893-021-01400-21471-2482https://doaj.org/article/6fca46e29f504acc82409252b69d1b282021-11-01T00:00:00Zhttps://doi.org/10.1186/s12893-021-01400-2https://doaj.org/toc/1471-2482Abstract Background To analyze the influence of inferior vena cava (IVC) interruption for perioperative and oncological results in patients with renal cell carcinoma and tumor thrombus and summarize the surgical strategies of IVC interruption for different situations. Methods We retrospectively analyzed the clinical and pathological data of 103 patients in our center. Patients were divided into two groups with 32 cases (31.1%) underwent IVC interruption (Group 1) while 71 cases (68.9%) did not. For comparison of continuous variables, the Mann–Whitney U test was used. For comparison of categorical variables, Chi-square tests were used. A propensity score based matching method was used to eliminate possible bias. Kaplan–Meier plots were performed to evaluate the influence of IVC interruption on overall survival and cancer specific survival. All the statistical analyses were performed using SPSS 24. A P value < 0.05 was considered statistically significant. Results Among the 32 patients who underwent IVC interruption, the median age was 61 years and the median tumor size was 7.7 cm. There were 28 males and 23 tumors were on the right side. We successfully matched 29 patients who underwent IVC interruption to 29 patients without this procedure in 1:1 ratio. No significant differences existed in baseline characteristics between the groups. The comparison of perioperative data showed that patients who underwent IVC interruption had significantly longer median postoperative hospital stays (13 vs 9 days, P = 0.022) and a higher overall postoperative complication rate (79.3 vs 51.7%, P = 0.027). According to the side and shape of tumor thrombus, it could be divided into four categories. There were 15 cases (46.9%) with right filled-type tumor thrombus (RFTT), 8 cases (25.0%) with right non-filled-type tumor thrombus (RNFTT), 1 case (3.1%) with left filled-type tumor thrombus (LFTT) and 8 cases (25.0%) with left non-filled-type tumor thrombus (LNFTT). According to different categories, different surgical procedures were adopted. Conclusions IVC interruption will increase the incidence of overall postoperative complications, but not the risk of major postoperative complications. Tumor thrombus should be divided into four categories, and different sides and shapes of renal tumor thrombus need different operative procedure of IVC interruption.Zhuo LiuQiming ZhangXun ZhaoGuodong ZhuShiying TangPeng HongLiyuan GeShudong ZhangGuoliang WangXiaojun TianHongxian ZhangCheng LiuLulin MaBMCarticleRenal cell carcinomaTumor thrombusInferior vena cava, interruptionSurgeryRD1-811ENBMC Surgery, Vol 21, Iss 1, Pp 1-10 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Renal cell carcinoma Tumor thrombus Inferior vena cava, interruption Surgery RD1-811 |
| spellingShingle |
Renal cell carcinoma Tumor thrombus Inferior vena cava, interruption Surgery RD1-811 Zhuo Liu Qiming Zhang Xun Zhao Guodong Zhu Shiying Tang Peng Hong Liyuan Ge Shudong Zhang Guoliang Wang Xiaojun Tian Hongxian Zhang Cheng Liu Lulin Ma Inferior vena cava interruption in renal cell carcinoma with tumor thrombus: surgical strategy and perioperative results |
| description |
Abstract Background To analyze the influence of inferior vena cava (IVC) interruption for perioperative and oncological results in patients with renal cell carcinoma and tumor thrombus and summarize the surgical strategies of IVC interruption for different situations. Methods We retrospectively analyzed the clinical and pathological data of 103 patients in our center. Patients were divided into two groups with 32 cases (31.1%) underwent IVC interruption (Group 1) while 71 cases (68.9%) did not. For comparison of continuous variables, the Mann–Whitney U test was used. For comparison of categorical variables, Chi-square tests were used. A propensity score based matching method was used to eliminate possible bias. Kaplan–Meier plots were performed to evaluate the influence of IVC interruption on overall survival and cancer specific survival. All the statistical analyses were performed using SPSS 24. A P value < 0.05 was considered statistically significant. Results Among the 32 patients who underwent IVC interruption, the median age was 61 years and the median tumor size was 7.7 cm. There were 28 males and 23 tumors were on the right side. We successfully matched 29 patients who underwent IVC interruption to 29 patients without this procedure in 1:1 ratio. No significant differences existed in baseline characteristics between the groups. The comparison of perioperative data showed that patients who underwent IVC interruption had significantly longer median postoperative hospital stays (13 vs 9 days, P = 0.022) and a higher overall postoperative complication rate (79.3 vs 51.7%, P = 0.027). According to the side and shape of tumor thrombus, it could be divided into four categories. There were 15 cases (46.9%) with right filled-type tumor thrombus (RFTT), 8 cases (25.0%) with right non-filled-type tumor thrombus (RNFTT), 1 case (3.1%) with left filled-type tumor thrombus (LFTT) and 8 cases (25.0%) with left non-filled-type tumor thrombus (LNFTT). According to different categories, different surgical procedures were adopted. Conclusions IVC interruption will increase the incidence of overall postoperative complications, but not the risk of major postoperative complications. Tumor thrombus should be divided into four categories, and different sides and shapes of renal tumor thrombus need different operative procedure of IVC interruption. |
| format |
article |
| author |
Zhuo Liu Qiming Zhang Xun Zhao Guodong Zhu Shiying Tang Peng Hong Liyuan Ge Shudong Zhang Guoliang Wang Xiaojun Tian Hongxian Zhang Cheng Liu Lulin Ma |
| author_facet |
Zhuo Liu Qiming Zhang Xun Zhao Guodong Zhu Shiying Tang Peng Hong Liyuan Ge Shudong Zhang Guoliang Wang Xiaojun Tian Hongxian Zhang Cheng Liu Lulin Ma |
| author_sort |
Zhuo Liu |
| title |
Inferior vena cava interruption in renal cell carcinoma with tumor thrombus: surgical strategy and perioperative results |
| title_short |
Inferior vena cava interruption in renal cell carcinoma with tumor thrombus: surgical strategy and perioperative results |
| title_full |
Inferior vena cava interruption in renal cell carcinoma with tumor thrombus: surgical strategy and perioperative results |
| title_fullStr |
Inferior vena cava interruption in renal cell carcinoma with tumor thrombus: surgical strategy and perioperative results |
| title_full_unstemmed |
Inferior vena cava interruption in renal cell carcinoma with tumor thrombus: surgical strategy and perioperative results |
| title_sort |
inferior vena cava interruption in renal cell carcinoma with tumor thrombus: surgical strategy and perioperative results |
| publisher |
BMC |
| publishDate |
2021 |
| url |
https://doaj.org/article/6fca46e29f504acc82409252b69d1b28 |
| work_keys_str_mv |
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