Red cell distribution width as a predictor of severity of acute pancreatitis

Introduction and Objective: Acute Pancreatitis (AP) is one of the most common surgical emergencies, a third of which becomes severe. Mortality rate of severe AP can reach up to 40%. Identification of those at risk of severe AP would allow early intervention to improve outcome Red cell distribution...

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Autores principales:	Ali Aafee, Rameshwar Prasad Pokharel
Formato:	article
Lenguaje:	EN
Publicado:	Society of Surgeons of Nepal 2016
Materias:	Acute pancreatitis severity red cell Distribution width Revised atlanta criteria Surgery RD1-811
Acceso en línea:	https://doaj.org/article/6fcb0bd4c78249599cbd61abe24dd8c9
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spelling	oai:doaj.org-article:6fcb0bd4c78249599cbd61abe24dd8c92021-12-05T19:16:41ZRed cell distribution width as a predictor of severity of acute pancreatitis10.3126/jssn.v18i3.152861815-39842392-4772https://doaj.org/article/6fcb0bd4c78249599cbd61abe24dd8c92016-07-01T00:00:00Zhttps://www.nepjol.info/index.php/JSSN/article/view/15286https://doaj.org/toc/1815-3984https://doaj.org/toc/2392-4772 Introduction and Objective: Acute Pancreatitis (AP) is one of the most common surgical emergencies, a third of which becomes severe. Mortality rate of severe AP can reach up to 40%. Identification of those at risk of severe AP would allow early intervention to improve outcome Red cell distribution width (RDW), an indicator of systemic inflammation has been show to be effective at predicting mortality in AP. The objective of this study was to determine whether admission RDW can predict severity of AP. Materials and Methods: A total of 74 patients admitted to Surgery Department in TUTH were included in this prospective study. Demographic data, admission time and laboratory parameters including RDW--?CV were obtained from each patient at admission. Reassessment was done at 48 hours. The patients were followed up till discharge. Severity of AP was classified by the 2012 revised Atlanta criteria. Results: A positive correlation between admission RDW - CV and severity of AP was found (Spearman’s rho 0.246, p value 0.034). ROC analysis revealed that admission RDW was accurate at predicting severe AP (AUC 0.733, 95% CI 0.612 to 0.854, p value 0.001) but was not accurate at differentiating mild from moderate AP ( AUC 0.510, 95% CI 0.291 to 0.729, p value 0.932). The cut off value for detecting severe AP was 13.7% with sensitivity of 66.7%, specificity 68.1%, PPV of 54.5 and NPV of 78. Conclusion: Admission RDW is as predictor of severe acute pancreatitis Ali AafeeRameshwar Prasad PokharelSociety of Surgeons of NepalarticleAcute pancreatitisseverityred cell Distribution widthRevised atlanta criteriaSurgeryRD1-811ENJournal of Society of Surgeons of Nepal, Vol 18, Iss 3 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Acute pancreatitis severity red cell Distribution width Revised atlanta criteria Surgery RD1-811
spellingShingle	Acute pancreatitis severity red cell Distribution width Revised atlanta criteria Surgery RD1-811 Ali Aafee Rameshwar Prasad Pokharel Red cell distribution width as a predictor of severity of acute pancreatitis
description	Introduction and Objective: Acute Pancreatitis (AP) is one of the most common surgical emergencies, a third of which becomes severe. Mortality rate of severe AP can reach up to 40%. Identification of those at risk of severe AP would allow early intervention to improve outcome Red cell distribution width (RDW), an indicator of systemic inflammation has been show to be effective at predicting mortality in AP. The objective of this study was to determine whether admission RDW can predict severity of AP. Materials and Methods: A total of 74 patients admitted to Surgery Department in TUTH were included in this prospective study. Demographic data, admission time and laboratory parameters including RDW--?CV were obtained from each patient at admission. Reassessment was done at 48 hours. The patients were followed up till discharge. Severity of AP was classified by the 2012 revised Atlanta criteria. Results: A positive correlation between admission RDW - CV and severity of AP was found (Spearman’s rho 0.246, p value 0.034). ROC analysis revealed that admission RDW was accurate at predicting severe AP (AUC 0.733, 95% CI 0.612 to 0.854, p value 0.001) but was not accurate at differentiating mild from moderate AP ( AUC 0.510, 95% CI 0.291 to 0.729, p value 0.932). The cut off value for detecting severe AP was 13.7% with sensitivity of 66.7%, specificity 68.1%, PPV of 54.5 and NPV of 78. Conclusion: Admission RDW is as predictor of severe acute pancreatitis
format	article
author	Ali Aafee Rameshwar Prasad Pokharel
author_facet	Ali Aafee Rameshwar Prasad Pokharel
author_sort	Ali Aafee
title	Red cell distribution width as a predictor of severity of acute pancreatitis
title_short	Red cell distribution width as a predictor of severity of acute pancreatitis
title_full	Red cell distribution width as a predictor of severity of acute pancreatitis
title_fullStr	Red cell distribution width as a predictor of severity of acute pancreatitis
title_full_unstemmed	Red cell distribution width as a predictor of severity of acute pancreatitis
title_sort	red cell distribution width as a predictor of severity of acute pancreatitis
publisher	Society of Surgeons of Nepal
publishDate	2016
url	https://doaj.org/article/6fcb0bd4c78249599cbd61abe24dd8c9
work_keys_str_mv	AT aliaafee redcelldistributionwidthasapredictorofseverityofacutepancreatitis AT rameshwarprasadpokharel redcelldistributionwidthasapredictorofseverityofacutepancreatitis
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Red cell distribution width as a predictor of severity of acute pancreatitis

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