Association between medication adherence and intrapatient variability in tacrolimus concentration among stable kidney transplant recipients

Abstract This study analyzed the association between medication adherence and the intrapatient variability (IPV) of tacrolimus concentrations among kidney transplant recipients through a post hoc analysis of the dataset from a recently conducted randomized controlled trial. Among 138 patients enroll...

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Autores principales:	Hyunmin Ko, Hyo Kee Kim, Chris Chung, Ahram Han, Seung-Kee Min, Jongwon Ha, Sangil Min
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6fcd0eb2110b417c9369a67f1db76f8b
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spelling	oai:doaj.org-article:6fcd0eb2110b417c9369a67f1db76f8b2021-12-02T13:34:51ZAssociation between medication adherence and intrapatient variability in tacrolimus concentration among stable kidney transplant recipients10.1038/s41598-021-84868-52045-2322https://doaj.org/article/6fcd0eb2110b417c9369a67f1db76f8b2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84868-5https://doaj.org/toc/2045-2322Abstract This study analyzed the association between medication adherence and the intrapatient variability (IPV) of tacrolimus concentrations among kidney transplant recipients through a post hoc analysis of the dataset from a recently conducted randomized controlled trial. Among 138 patients enrolled in the original trial, 92 patients with ≥ 5 months of medication event monitoring system (MEMS) use and ≥ 4 tacrolimus trough values were included in this post hoc analysis. The variability of tacrolimus trough levels was calculated using coefficient variation (CV) and mean absolute deviation. Adherence was assessed using MEMS and self-report via the Basal Assessment of Adherence to Immunosuppressive Medication Scale. There were no statistically significant differences in the CV [median 16.5% [interquartile range 11.6–25.5%] and 16.0% [11.5–23.5%], respectively, P = .602] between the nonadherent (n = 59) and adherent groups (n = 33). There was also no significant correlation between the CV and adherence detected by MEMS (taking adherence, ρ = − 0.067, P = .527; dosing adherence, ρ = − 0.098, P = .352; timing adherence, ρ = − 0.113, P = .284). Similarly, adherence measured by self-report did not significantly affect the IPV (P = .452). In this post hoc analysis, nonadherent behavior, measured through electronic monitoring or self-report, did not affect the IPV.Hyunmin KoHyo Kee KimChris ChungAhram HanSeung-Kee MinJongwon HaSangil MinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hyunmin Ko Hyo Kee Kim Chris Chung Ahram Han Seung-Kee Min Jongwon Ha Sangil Min Association between medication adherence and intrapatient variability in tacrolimus concentration among stable kidney transplant recipients
description	Abstract This study analyzed the association between medication adherence and the intrapatient variability (IPV) of tacrolimus concentrations among kidney transplant recipients through a post hoc analysis of the dataset from a recently conducted randomized controlled trial. Among 138 patients enrolled in the original trial, 92 patients with ≥ 5 months of medication event monitoring system (MEMS) use and ≥ 4 tacrolimus trough values were included in this post hoc analysis. The variability of tacrolimus trough levels was calculated using coefficient variation (CV) and mean absolute deviation. Adherence was assessed using MEMS and self-report via the Basal Assessment of Adherence to Immunosuppressive Medication Scale. There were no statistically significant differences in the CV [median 16.5% [interquartile range 11.6–25.5%] and 16.0% [11.5–23.5%], respectively, P = .602] between the nonadherent (n = 59) and adherent groups (n = 33). There was also no significant correlation between the CV and adherence detected by MEMS (taking adherence, ρ = − 0.067, P = .527; dosing adherence, ρ = − 0.098, P = .352; timing adherence, ρ = − 0.113, P = .284). Similarly, adherence measured by self-report did not significantly affect the IPV (P = .452). In this post hoc analysis, nonadherent behavior, measured through electronic monitoring or self-report, did not affect the IPV.
format	article
author	Hyunmin Ko Hyo Kee Kim Chris Chung Ahram Han Seung-Kee Min Jongwon Ha Sangil Min
author_facet	Hyunmin Ko Hyo Kee Kim Chris Chung Ahram Han Seung-Kee Min Jongwon Ha Sangil Min
author_sort	Hyunmin Ko
title	Association between medication adherence and intrapatient variability in tacrolimus concentration among stable kidney transplant recipients
title_short	Association between medication adherence and intrapatient variability in tacrolimus concentration among stable kidney transplant recipients
title_full	Association between medication adherence and intrapatient variability in tacrolimus concentration among stable kidney transplant recipients
title_fullStr	Association between medication adherence and intrapatient variability in tacrolimus concentration among stable kidney transplant recipients
title_full_unstemmed	Association between medication adherence and intrapatient variability in tacrolimus concentration among stable kidney transplant recipients
title_sort	association between medication adherence and intrapatient variability in tacrolimus concentration among stable kidney transplant recipients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6fcd0eb2110b417c9369a67f1db76f8b
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Association between medication adherence and intrapatient variability in tacrolimus concentration among stable kidney transplant recipients

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