Elevated cytokines and chemokines in peripheral blood of patients with SARS-CoV-2 pneumonia treated with high-titer convalescent plasma.

The global SARS-CoV-2 coronavirus pandemic continues to be devastating in many areas. Treatment options have been limited and convalescent donor plasma has been used by many centers to transfer passive neutralizing antibodies to patients with respiratory involvement. The results often vary by instit...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Stacey L Fanning, Robert Korngold, Zheng Yang, Kira Goldgirsh, Steven Park, Joshua Zenreich, Melissa Baker, Phyllis McKiernan, Ming Tan, Bingsong Zhang, Michele L Donato, David S Perlin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6fcd1544d54d45469990610c74eb95e3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6fcd1544d54d45469990610c74eb95e3
record_format	dspace
spelling	oai:doaj.org-article:6fcd1544d54d45469990610c74eb95e32021-12-02T19:59:54ZElevated cytokines and chemokines in peripheral blood of patients with SARS-CoV-2 pneumonia treated with high-titer convalescent plasma.1553-73661553-737410.1371/journal.ppat.1010025https://doaj.org/article/6fcd1544d54d45469990610c74eb95e32021-10-01T00:00:00Zhttps://doi.org/10.1371/journal.ppat.1010025https://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374The global SARS-CoV-2 coronavirus pandemic continues to be devastating in many areas. Treatment options have been limited and convalescent donor plasma has been used by many centers to transfer passive neutralizing antibodies to patients with respiratory involvement. The results often vary by institution and are complicated by the nature and quality of the donor plasma itself, the timing of administration and the clinical aspects of the recipients. SARS-CoV-2 infection is known to be associated with an increase in the blood concentrations of several inflammatory cytokines/chemokines, as part of the overall immune response to the virus and consequential to mediated lung pathology. Some of these correlates contribute to the cytokine storm syndrome and acute respiratory distress syndrome, often resulting in fatality. A Phase IIa clinical trial at our institution using high neutralizing titer convalescent plasma transfer gave us the unique opportunity to study the elevations of correlates in the first 10 days after infusion. Plasma recipients were divided into hospitalized COVID-19 pneumonia patients who did not (Track 2) or did (Track 3) require mechanical ventilation. Several cytokines were elevated in the patients of each Track and some continued to rise through Day 10, while others initially increased and then subsided. Furthermore, elevations in MIP-1α, MIP-1β and CRP correlated with disease progression of Track 2 recipients. Overall, our observations serve as a foundation for further study of these correlates and the identification of potential biomarkers to improve upon convalescent plasma therapy and to drive more successful patient outcomes.Stacey L FanningRobert KorngoldZheng YangKira GoldgirshSteven ParkJoshua ZenreichMelissa BakerPhyllis McKiernanMing TanBingsong ZhangMichele L DonatoDavid S PerlinPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 17, Iss 10, p e1010025 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Stacey L Fanning Robert Korngold Zheng Yang Kira Goldgirsh Steven Park Joshua Zenreich Melissa Baker Phyllis McKiernan Ming Tan Bingsong Zhang Michele L Donato David S Perlin Elevated cytokines and chemokines in peripheral blood of patients with SARS-CoV-2 pneumonia treated with high-titer convalescent plasma.
description	The global SARS-CoV-2 coronavirus pandemic continues to be devastating in many areas. Treatment options have been limited and convalescent donor plasma has been used by many centers to transfer passive neutralizing antibodies to patients with respiratory involvement. The results often vary by institution and are complicated by the nature and quality of the donor plasma itself, the timing of administration and the clinical aspects of the recipients. SARS-CoV-2 infection is known to be associated with an increase in the blood concentrations of several inflammatory cytokines/chemokines, as part of the overall immune response to the virus and consequential to mediated lung pathology. Some of these correlates contribute to the cytokine storm syndrome and acute respiratory distress syndrome, often resulting in fatality. A Phase IIa clinical trial at our institution using high neutralizing titer convalescent plasma transfer gave us the unique opportunity to study the elevations of correlates in the first 10 days after infusion. Plasma recipients were divided into hospitalized COVID-19 pneumonia patients who did not (Track 2) or did (Track 3) require mechanical ventilation. Several cytokines were elevated in the patients of each Track and some continued to rise through Day 10, while others initially increased and then subsided. Furthermore, elevations in MIP-1α, MIP-1β and CRP correlated with disease progression of Track 2 recipients. Overall, our observations serve as a foundation for further study of these correlates and the identification of potential biomarkers to improve upon convalescent plasma therapy and to drive more successful patient outcomes.
format	article
author	Stacey L Fanning Robert Korngold Zheng Yang Kira Goldgirsh Steven Park Joshua Zenreich Melissa Baker Phyllis McKiernan Ming Tan Bingsong Zhang Michele L Donato David S Perlin
author_facet	Stacey L Fanning Robert Korngold Zheng Yang Kira Goldgirsh Steven Park Joshua Zenreich Melissa Baker Phyllis McKiernan Ming Tan Bingsong Zhang Michele L Donato David S Perlin
author_sort	Stacey L Fanning
title	Elevated cytokines and chemokines in peripheral blood of patients with SARS-CoV-2 pneumonia treated with high-titer convalescent plasma.
title_short	Elevated cytokines and chemokines in peripheral blood of patients with SARS-CoV-2 pneumonia treated with high-titer convalescent plasma.
title_full	Elevated cytokines and chemokines in peripheral blood of patients with SARS-CoV-2 pneumonia treated with high-titer convalescent plasma.
title_fullStr	Elevated cytokines and chemokines in peripheral blood of patients with SARS-CoV-2 pneumonia treated with high-titer convalescent plasma.
title_full_unstemmed	Elevated cytokines and chemokines in peripheral blood of patients with SARS-CoV-2 pneumonia treated with high-titer convalescent plasma.
title_sort	elevated cytokines and chemokines in peripheral blood of patients with sars-cov-2 pneumonia treated with high-titer convalescent plasma.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/6fcd1544d54d45469990610c74eb95e3
work_keys_str_mv	AT staceylfanning elevatedcytokinesandchemokinesinperipheralbloodofpatientswithsarscov2pneumoniatreatedwithhightiterconvalescentplasma AT robertkorngold elevatedcytokinesandchemokinesinperipheralbloodofpatientswithsarscov2pneumoniatreatedwithhightiterconvalescentplasma AT zhengyang elevatedcytokinesandchemokinesinperipheralbloodofpatientswithsarscov2pneumoniatreatedwithhightiterconvalescentplasma AT kiragoldgirsh elevatedcytokinesandchemokinesinperipheralbloodofpatientswithsarscov2pneumoniatreatedwithhightiterconvalescentplasma AT stevenpark elevatedcytokinesandchemokinesinperipheralbloodofpatientswithsarscov2pneumoniatreatedwithhightiterconvalescentplasma AT joshuazenreich elevatedcytokinesandchemokinesinperipheralbloodofpatientswithsarscov2pneumoniatreatedwithhightiterconvalescentplasma AT melissabaker elevatedcytokinesandchemokinesinperipheralbloodofpatientswithsarscov2pneumoniatreatedwithhightiterconvalescentplasma AT phyllismckiernan elevatedcytokinesandchemokinesinperipheralbloodofpatientswithsarscov2pneumoniatreatedwithhightiterconvalescentplasma AT mingtan elevatedcytokinesandchemokinesinperipheralbloodofpatientswithsarscov2pneumoniatreatedwithhightiterconvalescentplasma AT bingsongzhang elevatedcytokinesandchemokinesinperipheralbloodofpatientswithsarscov2pneumoniatreatedwithhightiterconvalescentplasma AT micheleldonato elevatedcytokinesandchemokinesinperipheralbloodofpatientswithsarscov2pneumoniatreatedwithhightiterconvalescentplasma AT davidsperlin elevatedcytokinesandchemokinesinperipheralbloodofpatientswithsarscov2pneumoniatreatedwithhightiterconvalescentplasma
_version_	1718375728371728384

Elevated cytokines and chemokines in peripheral blood of patients with SARS-CoV-2 pneumonia treated with high-titer convalescent plasma.

Ejemplares similares