Cardiac endothelium: More than just a barrier

Cardiac endothelium consists of highly specialised endothelial cells that are custom-designed to influence and regulate myocardial function. Various bioactive molecules, such as nitric oxide (NO) are released and given the short diffusion distance between especially the myocardial capillary endothel...

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Autores principales:	Hans Strijdom, Amanda Lochner
Formato:	article
Lenguaje:	EN
Publicado:	South African Heart Association 2017
Materias:	cardiac endothelium cardiac micro vascular endothelial cells Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/6fcd16b36dba4084b5664b02d7a9a6a5
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spelling	oai:doaj.org-article:6fcd16b36dba4084b5664b02d7a9a6a52021-11-22T08:49:14ZCardiac endothelium: More than just a barrier10.24170/6-3-19871996-67412071-4602https://doaj.org/article/6fcd16b36dba4084b5664b02d7a9a6a52017-04-01T00:00:00Zhttps://www.journals.ac.za/index.php/SAHJ/article/view/1987https://doaj.org/toc/1996-6741https://doaj.org/toc/2071-4602Cardiac endothelium consists of highly specialised endothelial cells that are custom-designed to influence and regulate myocardial function. Various bioactive molecules, such as nitric oxide (NO) are released and given the short diffusion distance between especially the myocardial capillary endothelial cells (cardiac microvascular endothelial cells, CMECs) and adjacent cardiomyocytes, an ideal microenvironment is created for paracrine communication. In this review paper, the relative role of the CMECs with regard to NO generation, the mechanisms of NO generation, and possible consequences of the released NO are described. Particular attention is given to these parameters under conditions of oxygen deficiency, as this is one of the most common pathophysiological conditions affecting the heart.Hans StrijdomAmanda LochnerSouth African Heart Associationarticlecardiac endotheliumcardiac micro vascular endothelial cellsDiseases of the circulatory (Cardiovascular) systemRC666-701ENSA Heart Journal, Vol 6, Iss 3, Pp 174-185 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiac endothelium cardiac micro vascular endothelial cells Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	cardiac endothelium cardiac micro vascular endothelial cells Diseases of the circulatory (Cardiovascular) system RC666-701 Hans Strijdom Amanda Lochner Cardiac endothelium: More than just a barrier
description	Cardiac endothelium consists of highly specialised endothelial cells that are custom-designed to influence and regulate myocardial function. Various bioactive molecules, such as nitric oxide (NO) are released and given the short diffusion distance between especially the myocardial capillary endothelial cells (cardiac microvascular endothelial cells, CMECs) and adjacent cardiomyocytes, an ideal microenvironment is created for paracrine communication. In this review paper, the relative role of the CMECs with regard to NO generation, the mechanisms of NO generation, and possible consequences of the released NO are described. Particular attention is given to these parameters under conditions of oxygen deficiency, as this is one of the most common pathophysiological conditions affecting the heart.
format	article
author	Hans Strijdom Amanda Lochner
author_facet	Hans Strijdom Amanda Lochner
author_sort	Hans Strijdom
title	Cardiac endothelium: More than just a barrier
title_short	Cardiac endothelium: More than just a barrier
title_full	Cardiac endothelium: More than just a barrier
title_fullStr	Cardiac endothelium: More than just a barrier
title_full_unstemmed	Cardiac endothelium: More than just a barrier
title_sort	cardiac endothelium: more than just a barrier
publisher	South African Heart Association
publishDate	2017
url	https://doaj.org/article/6fcd16b36dba4084b5664b02d7a9a6a5
work_keys_str_mv	AT hansstrijdom cardiacendotheliummorethanjustabarrier AT amandalochner cardiacendotheliummorethanjustabarrier
_version_	1718417800620408832

Cardiac endothelium: More than just a barrier

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