Microstructure, Mechanical Properties, Degradation Behavior, and Implant Testing of Hot-Rolled Biodegradable ZKX500 Magnesium Alloy

Currently, orthopedic metallic implants are mostly made of stainless steel and titanium alloys. After healing, patients are usually required to undergo a secondary surgery for implant removal, which not only poses a medical risk but also costs medical resources. Magnesium-based biodegradable implant...

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Autores principales:	Ying-Ting Huang, Fei-Yi Hung, Fa-Chuan Kuan, Kai-Lan Hsu, Wei-Ren Su, Chia-Yen Lin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	magnesium alloy biodegradation mechanical properties animal experiment bone plate Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/6fcdf1eeb73e47f4bce97a30f819dc5f
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spelling	oai:doaj.org-article:6fcdf1eeb73e47f4bce97a30f819dc5f2021-11-25T16:35:34ZMicrostructure, Mechanical Properties, Degradation Behavior, and Implant Testing of Hot-Rolled Biodegradable ZKX500 Magnesium Alloy10.3390/app1122106772076-3417https://doaj.org/article/6fcdf1eeb73e47f4bce97a30f819dc5f2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/22/10677https://doaj.org/toc/2076-3417Currently, orthopedic metallic implants are mostly made of stainless steel and titanium alloys. After healing, patients are usually required to undergo a secondary surgery for implant removal, which not only poses a medical risk but also costs medical resources. Magnesium-based biodegradable implants that can be absorbed by humans promote osteoblastic activity during the degradation and inhibit the formation of osteoclasts. Moreover, magnesium can be detected by X-ray, and this can help doctors to perform postoperative diagnosis and treatment, which is beneficial for patients. In this study, a ZKX500 Mg alloy bone plate was prepared through rolling. In addition to the microstructure and the mechanical properties of the hot-rolled ZKX500 Mg alloy, its in vitro corrosion behavior under different heat treatment conditions is discussed. A 6-month mini-pig implantation test was conducted using the fabricated ZKX500 Mg alloy bone plate and bone screws. The in vivo degradation mechanism and new bone formation were observed using computed tomography images. The pig recovered well, and the results can serve as an important reference for clinical applications. In addition, another important contribution of this study is that it can help the field of orthopedics to better understand the biodegradable magnesium alloy.Ying-Ting HuangFei-Yi HungFa-Chuan KuanKai-Lan HsuWei-Ren SuChia-Yen LinMDPI AGarticlemagnesium alloybiodegradationmechanical propertiesanimal experimentbone plateTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10677, p 10677 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	magnesium alloy biodegradation mechanical properties animal experiment bone plate Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	magnesium alloy biodegradation mechanical properties animal experiment bone plate Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Ying-Ting Huang Fei-Yi Hung Fa-Chuan Kuan Kai-Lan Hsu Wei-Ren Su Chia-Yen Lin Microstructure, Mechanical Properties, Degradation Behavior, and Implant Testing of Hot-Rolled Biodegradable ZKX500 Magnesium Alloy
description	Currently, orthopedic metallic implants are mostly made of stainless steel and titanium alloys. After healing, patients are usually required to undergo a secondary surgery for implant removal, which not only poses a medical risk but also costs medical resources. Magnesium-based biodegradable implants that can be absorbed by humans promote osteoblastic activity during the degradation and inhibit the formation of osteoclasts. Moreover, magnesium can be detected by X-ray, and this can help doctors to perform postoperative diagnosis and treatment, which is beneficial for patients. In this study, a ZKX500 Mg alloy bone plate was prepared through rolling. In addition to the microstructure and the mechanical properties of the hot-rolled ZKX500 Mg alloy, its in vitro corrosion behavior under different heat treatment conditions is discussed. A 6-month mini-pig implantation test was conducted using the fabricated ZKX500 Mg alloy bone plate and bone screws. The in vivo degradation mechanism and new bone formation were observed using computed tomography images. The pig recovered well, and the results can serve as an important reference for clinical applications. In addition, another important contribution of this study is that it can help the field of orthopedics to better understand the biodegradable magnesium alloy.
format	article
author	Ying-Ting Huang Fei-Yi Hung Fa-Chuan Kuan Kai-Lan Hsu Wei-Ren Su Chia-Yen Lin
author_facet	Ying-Ting Huang Fei-Yi Hung Fa-Chuan Kuan Kai-Lan Hsu Wei-Ren Su Chia-Yen Lin
author_sort	Ying-Ting Huang
title	Microstructure, Mechanical Properties, Degradation Behavior, and Implant Testing of Hot-Rolled Biodegradable ZKX500 Magnesium Alloy
title_short	Microstructure, Mechanical Properties, Degradation Behavior, and Implant Testing of Hot-Rolled Biodegradable ZKX500 Magnesium Alloy
title_full	Microstructure, Mechanical Properties, Degradation Behavior, and Implant Testing of Hot-Rolled Biodegradable ZKX500 Magnesium Alloy
title_fullStr	Microstructure, Mechanical Properties, Degradation Behavior, and Implant Testing of Hot-Rolled Biodegradable ZKX500 Magnesium Alloy
title_full_unstemmed	Microstructure, Mechanical Properties, Degradation Behavior, and Implant Testing of Hot-Rolled Biodegradable ZKX500 Magnesium Alloy
title_sort	microstructure, mechanical properties, degradation behavior, and implant testing of hot-rolled biodegradable zkx500 magnesium alloy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6fcdf1eeb73e47f4bce97a30f819dc5f
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Microstructure, Mechanical Properties, Degradation Behavior, and Implant Testing of Hot-Rolled Biodegradable ZKX500 Magnesium Alloy

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