Gut microbiota mediate the FGF21 adaptive stress response to chronic dietary protein-restriction in mice

Dietary protein restriction induces a hepatic stress response mediated by the endocrine molecule FGF21, which triggers host adaptive pathways. Here the authors demonstrate that the gut microbiome is required to trigger the FGF21 response and can be manipulated through dietary fiber supplementation.

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Autores principales:	Anthony Martin, Gertrude Ecklu-Mensah, Connie W. Y. Ha, Gustaf Hendrick, Donald K. Layman, Jack Gilbert, Suzanne Devkota
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6fce210c69ab40e0aad80206c5bdb102
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spelling	oai:doaj.org-article:6fce210c69ab40e0aad80206c5bdb1022021-12-02T16:06:02ZGut microbiota mediate the FGF21 adaptive stress response to chronic dietary protein-restriction in mice10.1038/s41467-021-24074-z2041-1723https://doaj.org/article/6fce210c69ab40e0aad80206c5bdb1022021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24074-zhttps://doaj.org/toc/2041-1723Dietary protein restriction induces a hepatic stress response mediated by the endocrine molecule FGF21, which triggers host adaptive pathways. Here the authors demonstrate that the gut microbiome is required to trigger the FGF21 response and can be manipulated through dietary fiber supplementation.Anthony MartinGertrude Ecklu-MensahConnie W. Y. HaGustaf HendrickDonald K. LaymanJack GilbertSuzanne DevkotaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anthony Martin Gertrude Ecklu-Mensah Connie W. Y. Ha Gustaf Hendrick Donald K. Layman Jack Gilbert Suzanne Devkota Gut microbiota mediate the FGF21 adaptive stress response to chronic dietary protein-restriction in mice
description	Dietary protein restriction induces a hepatic stress response mediated by the endocrine molecule FGF21, which triggers host adaptive pathways. Here the authors demonstrate that the gut microbiome is required to trigger the FGF21 response and can be manipulated through dietary fiber supplementation.
format	article
author	Anthony Martin Gertrude Ecklu-Mensah Connie W. Y. Ha Gustaf Hendrick Donald K. Layman Jack Gilbert Suzanne Devkota
author_facet	Anthony Martin Gertrude Ecklu-Mensah Connie W. Y. Ha Gustaf Hendrick Donald K. Layman Jack Gilbert Suzanne Devkota
author_sort	Anthony Martin
title	Gut microbiota mediate the FGF21 adaptive stress response to chronic dietary protein-restriction in mice
title_short	Gut microbiota mediate the FGF21 adaptive stress response to chronic dietary protein-restriction in mice
title_full	Gut microbiota mediate the FGF21 adaptive stress response to chronic dietary protein-restriction in mice
title_fullStr	Gut microbiota mediate the FGF21 adaptive stress response to chronic dietary protein-restriction in mice
title_full_unstemmed	Gut microbiota mediate the FGF21 adaptive stress response to chronic dietary protein-restriction in mice
title_sort	gut microbiota mediate the fgf21 adaptive stress response to chronic dietary protein-restriction in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6fce210c69ab40e0aad80206c5bdb102
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Gut microbiota mediate the FGF21 adaptive stress response to chronic dietary protein-restriction in mice

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