Frequency and visual outcomes of ocular toxoplasmosis in an adult Brazilian population

Abstract Although ocular toxoplasmosis is a leading cause of posterior uveitis worldwide, there is scarce information about the real-life frequency of ocular lesions, visual outcomes, and risk factors for poor prognosis. We conducted a community-based cross-sectional study with 721 adults living in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rafael Estevão De Angelis, Maria de Lourdes Veronese Rodrigues, Afonso Dinis Costa Passos, Valdes Roberto Bollela, Milena Simões Freitas e Silva, Bárbara Regina Vieira, Moisés Moura de Lucena, Thais David Moralles, Luciana de Morais Vicente, Gutemberg de Melo Rocha, Rodrigo Jorge, Jayter S. Paula, João M. Furtado
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6fd3173a9fba4d589ae956d6c24dbc06
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6fd3173a9fba4d589ae956d6c24dbc06
record_format	dspace
spelling	oai:doaj.org-article:6fd3173a9fba4d589ae956d6c24dbc062021-12-02T14:26:48ZFrequency and visual outcomes of ocular toxoplasmosis in an adult Brazilian population10.1038/s41598-021-83051-02045-2322https://doaj.org/article/6fd3173a9fba4d589ae956d6c24dbc062021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83051-0https://doaj.org/toc/2045-2322Abstract Although ocular toxoplasmosis is a leading cause of posterior uveitis worldwide, there is scarce information about the real-life frequency of ocular lesions, visual outcomes, and risk factors for poor prognosis. We conducted a community-based cross-sectional study with 721 adults living in Cássia dos Coqueiros, Southeast Brazil, consisted of visual acuity measurement, dilated ocular examination, a risk-factor questionnaire, and peripheral blood collection for anti-T. gondii serology. Presumed toxoplasmic lesions were recorded on video and analyzed by experienced and masked ophthalmologists. Ocular toxoplasmosis was determined if at least one suspected lesion was appointed by two graders in the presence of positive anti-T. gondii serology. Forty-eight eyes (n = 42 participants; 6.7% among those with positive anti-T. gondii serology) with ocular toxoplasmosis were found. Most lesions were single (n = 28; 58.3%), peripheral (n = 34; 77.1%) and unilateral (85.7% of participants); no active lesions were found. Older age was associated with lesions larger than one-disc diameter (p = 0.047), and lower social stratum (OR: 2.89; CI 1.2–6.97; p = 0.018) was associated with the presence of toxoplasmic lesions. Although there were no differences in visual acuity between participants and eyes with or without ocular lesions (p > 0.05), unilateral blindness associated with ocular toxoplasmosis was identified in a reduced number of individuals.Rafael Estevão De AngelisMaria de Lourdes Veronese RodriguesAfonso Dinis Costa PassosValdes Roberto BollelaMilena Simões Freitas e SilvaBárbara Regina VieiraMoisés Moura de LucenaThais David MorallesLuciana de Morais VicenteGutemberg de Melo RochaRodrigo JorgeJayter S. PaulaJoão M. FurtadoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rafael Estevão De Angelis Maria de Lourdes Veronese Rodrigues Afonso Dinis Costa Passos Valdes Roberto Bollela Milena Simões Freitas e Silva Bárbara Regina Vieira Moisés Moura de Lucena Thais David Moralles Luciana de Morais Vicente Gutemberg de Melo Rocha Rodrigo Jorge Jayter S. Paula João M. Furtado Frequency and visual outcomes of ocular toxoplasmosis in an adult Brazilian population
description	Abstract Although ocular toxoplasmosis is a leading cause of posterior uveitis worldwide, there is scarce information about the real-life frequency of ocular lesions, visual outcomes, and risk factors for poor prognosis. We conducted a community-based cross-sectional study with 721 adults living in Cássia dos Coqueiros, Southeast Brazil, consisted of visual acuity measurement, dilated ocular examination, a risk-factor questionnaire, and peripheral blood collection for anti-T. gondii serology. Presumed toxoplasmic lesions were recorded on video and analyzed by experienced and masked ophthalmologists. Ocular toxoplasmosis was determined if at least one suspected lesion was appointed by two graders in the presence of positive anti-T. gondii serology. Forty-eight eyes (n = 42 participants; 6.7% among those with positive anti-T. gondii serology) with ocular toxoplasmosis were found. Most lesions were single (n = 28; 58.3%), peripheral (n = 34; 77.1%) and unilateral (85.7% of participants); no active lesions were found. Older age was associated with lesions larger than one-disc diameter (p = 0.047), and lower social stratum (OR: 2.89; CI 1.2–6.97; p = 0.018) was associated with the presence of toxoplasmic lesions. Although there were no differences in visual acuity between participants and eyes with or without ocular lesions (p > 0.05), unilateral blindness associated with ocular toxoplasmosis was identified in a reduced number of individuals.
format	article
author	Rafael Estevão De Angelis Maria de Lourdes Veronese Rodrigues Afonso Dinis Costa Passos Valdes Roberto Bollela Milena Simões Freitas e Silva Bárbara Regina Vieira Moisés Moura de Lucena Thais David Moralles Luciana de Morais Vicente Gutemberg de Melo Rocha Rodrigo Jorge Jayter S. Paula João M. Furtado
author_facet	Rafael Estevão De Angelis Maria de Lourdes Veronese Rodrigues Afonso Dinis Costa Passos Valdes Roberto Bollela Milena Simões Freitas e Silva Bárbara Regina Vieira Moisés Moura de Lucena Thais David Moralles Luciana de Morais Vicente Gutemberg de Melo Rocha Rodrigo Jorge Jayter S. Paula João M. Furtado
author_sort	Rafael Estevão De Angelis
title	Frequency and visual outcomes of ocular toxoplasmosis in an adult Brazilian population
title_short	Frequency and visual outcomes of ocular toxoplasmosis in an adult Brazilian population
title_full	Frequency and visual outcomes of ocular toxoplasmosis in an adult Brazilian population
title_fullStr	Frequency and visual outcomes of ocular toxoplasmosis in an adult Brazilian population
title_full_unstemmed	Frequency and visual outcomes of ocular toxoplasmosis in an adult Brazilian population
title_sort	frequency and visual outcomes of ocular toxoplasmosis in an adult brazilian population
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6fd3173a9fba4d589ae956d6c24dbc06
work_keys_str_mv	AT rafaelestevaodeangelis frequencyandvisualoutcomesofoculartoxoplasmosisinanadultbrazilianpopulation AT mariadelourdesveroneserodrigues frequencyandvisualoutcomesofoculartoxoplasmosisinanadultbrazilianpopulation AT afonsodiniscostapassos frequencyandvisualoutcomesofoculartoxoplasmosisinanadultbrazilianpopulation AT valdesrobertobollela frequencyandvisualoutcomesofoculartoxoplasmosisinanadultbrazilianpopulation AT milenasimoesfreitasesilva frequencyandvisualoutcomesofoculartoxoplasmosisinanadultbrazilianpopulation AT barbarareginavieira frequencyandvisualoutcomesofoculartoxoplasmosisinanadultbrazilianpopulation AT moisesmouradelucena frequencyandvisualoutcomesofoculartoxoplasmosisinanadultbrazilianpopulation AT thaisdavidmoralles frequencyandvisualoutcomesofoculartoxoplasmosisinanadultbrazilianpopulation AT lucianademoraisvicente frequencyandvisualoutcomesofoculartoxoplasmosisinanadultbrazilianpopulation AT gutembergdemelorocha frequencyandvisualoutcomesofoculartoxoplasmosisinanadultbrazilianpopulation AT rodrigojorge frequencyandvisualoutcomesofoculartoxoplasmosisinanadultbrazilianpopulation AT jayterspaula frequencyandvisualoutcomesofoculartoxoplasmosisinanadultbrazilianpopulation AT joaomfurtado frequencyandvisualoutcomesofoculartoxoplasmosisinanadultbrazilianpopulation
_version_	1718391317363425280

Frequency and visual outcomes of ocular toxoplasmosis in an adult Brazilian population

Ejemplares similares