Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions

Yu Li,1– 3 Qing Xiao,1– 3 Jie Tang,2– 4 Lidan Xiong,2– 4 Li Li1– 4 1Department of Dermatology, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 2Cosmetics Safety and Efficacy Evaluation Center, West China Hospital, Sichuan University, Chengdu, 610041, People’s Re...

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Autores principales:	Li Y, Xiao Q, Tang J, Xiong L, Li L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	extracellular vesicles skin diseases plant clinical trials Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6fd355b6bd07452e99141ce94942e444
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spelling	oai:doaj.org-article:6fd355b6bd07452e99141ce94942e4442021-12-02T18:51:43ZExtracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions1178-2013https://doaj.org/article/6fd355b6bd07452e99141ce94942e4442021-09-01T00:00:00Zhttps://www.dovepress.com/extracellular-vesicles-emerging-therapeutics-in-cutaneous-lesions-peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Yu Li,1– 3 Qing Xiao,1– 3 Jie Tang,2– 4 Lidan Xiong,2– 4 Li Li1– 4 1Department of Dermatology, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 2Cosmetics Safety and Efficacy Evaluation Center, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 3NMPA Key Laboratory for Human Evaluation and Big Data of Cosmetics, Chengdu, 610041, People’s Republic of China; 4Sichuan Engineering Technology Research Center of Cosmetic, Chengdu, 610041, People’s Republic of ChinaCorrespondence: Li LiDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of ChinaEmail lilihx_scu@scu.edu.cnLidan XiongCosmetics Safety and Efficacy Evaluation Center, West China Hospital, Sichuan University, No. 5, Gong Xing Road, Chengdu, Sichuan, 610041, People’s Republic of ChinaEmail beardan0505@163.comAbstract: Extracellular vesicles (EVs), as nanoscale membranous vesicles containing DNAs, RNAs, lipids and proteins, have emerged as promising diagnostic and therapeutic agents for skin diseases. Here, we summarize the basic physiology of the skin and the biological characteristic of EVs. Further, we describe the applications of EVs in the treatment of dermatological conditions such as skin infection, inflammatory skin diseases, skin repair and rejuvenation and skin cancer. In particular, plant-derived EVs and clinical trials are discussed. In addition, challenges and perspectives related to the preclinical and clinical applications of EVs are highlighted.Keywords: extracellular vesicles, skin diseases, plant, clinical trialsLi YXiao QTang JXiong LLi LDove Medical Pressarticleextracellular vesiclesskin diseasesplantclinical trialsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 6183-6202 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	extracellular vesicles skin diseases plant clinical trials Medicine (General) R5-920
spellingShingle	extracellular vesicles skin diseases plant clinical trials Medicine (General) R5-920 Li Y Xiao Q Tang J Xiong L Li L Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions
description	Yu Li,1– 3 Qing Xiao,1– 3 Jie Tang,2– 4 Lidan Xiong,2– 4 Li Li1– 4 1Department of Dermatology, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 2Cosmetics Safety and Efficacy Evaluation Center, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 3NMPA Key Laboratory for Human Evaluation and Big Data of Cosmetics, Chengdu, 610041, People’s Republic of China; 4Sichuan Engineering Technology Research Center of Cosmetic, Chengdu, 610041, People’s Republic of ChinaCorrespondence: Li LiDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of ChinaEmail lilihx_scu@scu.edu.cnLidan XiongCosmetics Safety and Efficacy Evaluation Center, West China Hospital, Sichuan University, No. 5, Gong Xing Road, Chengdu, Sichuan, 610041, People’s Republic of ChinaEmail beardan0505@163.comAbstract: Extracellular vesicles (EVs), as nanoscale membranous vesicles containing DNAs, RNAs, lipids and proteins, have emerged as promising diagnostic and therapeutic agents for skin diseases. Here, we summarize the basic physiology of the skin and the biological characteristic of EVs. Further, we describe the applications of EVs in the treatment of dermatological conditions such as skin infection, inflammatory skin diseases, skin repair and rejuvenation and skin cancer. In particular, plant-derived EVs and clinical trials are discussed. In addition, challenges and perspectives related to the preclinical and clinical applications of EVs are highlighted.Keywords: extracellular vesicles, skin diseases, plant, clinical trials
format	article
author	Li Y Xiao Q Tang J Xiong L Li L
author_facet	Li Y Xiao Q Tang J Xiong L Li L
author_sort	Li Y
title	Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions
title_short	Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions
title_full	Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions
title_fullStr	Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions
title_full_unstemmed	Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions
title_sort	extracellular vesicles: emerging therapeutics in cutaneous lesions
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/6fd355b6bd07452e99141ce94942e444
work_keys_str_mv	AT liy extracellularvesiclesemergingtherapeuticsincutaneouslesions AT xiaoq extracellularvesiclesemergingtherapeuticsincutaneouslesions AT tangj extracellularvesiclesemergingtherapeuticsincutaneouslesions AT xiongl extracellularvesiclesemergingtherapeuticsincutaneouslesions AT lil extracellularvesiclesemergingtherapeuticsincutaneouslesions
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Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions

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