A comprehensive map of alternative polyadenylation in African American and European American lung cancer patients

Alternative polyadenylation (APA) regulates the length of the 3′UTR of mRNA. Here, the authors describe a method to accurately measure APA in tumours and apply this method to investigate the differences in APA in African American and European American lung cancer samples.

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Auteurs principaux: Adriana Zingone, Sanju Sinha, Michael Ante, Cu Nguyen, Dalia Daujotyte, Elise D. Bowman, Neelam Sinha, Khadijah A. Mitchell, Qingrong Chen, Chunhua Yan, Phillipe Loher, Daoud Meerzaman, Eytan Ruppin, Bríd M. Ryan
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/6fd436d5357e43f98a5a57bc9ef4218b
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Résumé:Alternative polyadenylation (APA) regulates the length of the 3′UTR of mRNA. Here, the authors describe a method to accurately measure APA in tumours and apply this method to investigate the differences in APA in African American and European American lung cancer samples.