Effects of melatonin in experimental stroke models in acute, sub-acute, and chronic stages

Hsiao-Wen Lin, E-Jian LeeNeurophysiology Laboratory, Neurosurgical Service, Department of Surgery, National Cheng Kung University Medical Center and Medical School, Tainan, TaiwanAbstract: Melatonin (N-acetyl-5-methoxy-tryptamine), a naturally occurring indole produced mainly by the pineal gland, is...

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Autores principales:	Hsiao-Wen Lin, E-Jian Lee
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/6fd5d1a077bf435ea9009057bda51f9e
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spelling	oai:doaj.org-article:6fd5d1a077bf435ea9009057bda51f9e2021-12-02T03:50:33ZEffects of melatonin in experimental stroke models in acute, sub-acute, and chronic stages1176-63281178-2021https://doaj.org/article/6fd5d1a077bf435ea9009057bda51f9e2009-03-01T00:00:00Zhttp://www.dovepress.com/effects-of-melatonin-in-experimental-stroke-models-in-acute-sub-acute--a2928https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Hsiao-Wen Lin, E-Jian LeeNeurophysiology Laboratory, Neurosurgical Service, Department of Surgery, National Cheng Kung University Medical Center and Medical School, Tainan, TaiwanAbstract: Melatonin (N-acetyl-5-methoxy-tryptamine), a naturally occurring indole produced mainly by the pineal gland, is a well known antioxidant. Stroke (cerebral ischemia) is the second leading cause of death worldwide. To date, however, effective and safe treatment for stroke remains unavailable. Melatonin is both lipid- and water-soluble and readily crosses the blood&ndash;brain barrier (BBB). Increasing evidence has shown that, in animal stroke models, administering melatonin significantly reduces infarct volume, edema, and oxidative damage and improves electrophysiological and behavioral performance. Here, we reviewed studies that assess effects of melatonin on cerebral ischemia in acute, sub-acute, and chronic stages. In addition to its potent antioxidant properties, melatonin exerts antiapoptotic, antiexcitotoxic, anti-inflammatory effects and promotes mitochondrial functions in animals with cerebral ischemia. Given that melatonin shows almost no toxicity to humans and possesses multifaceted protective capacity against cerebral ischemia, it is valuable to consider using melatonin in clinical trials on patients suffering from stroke.Keywords: cerebral ischemia, melatonin, stroke, neuroprotection Hsiao-Wen LinE-Jian LeeDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2009, Iss default, Pp 157-162 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Hsiao-Wen Lin E-Jian Lee Effects of melatonin in experimental stroke models in acute, sub-acute, and chronic stages
description	Hsiao-Wen Lin, E-Jian LeeNeurophysiology Laboratory, Neurosurgical Service, Department of Surgery, National Cheng Kung University Medical Center and Medical School, Tainan, TaiwanAbstract: Melatonin (N-acetyl-5-methoxy-tryptamine), a naturally occurring indole produced mainly by the pineal gland, is a well known antioxidant. Stroke (cerebral ischemia) is the second leading cause of death worldwide. To date, however, effective and safe treatment for stroke remains unavailable. Melatonin is both lipid- and water-soluble and readily crosses the blood&ndash;brain barrier (BBB). Increasing evidence has shown that, in animal stroke models, administering melatonin significantly reduces infarct volume, edema, and oxidative damage and improves electrophysiological and behavioral performance. Here, we reviewed studies that assess effects of melatonin on cerebral ischemia in acute, sub-acute, and chronic stages. In addition to its potent antioxidant properties, melatonin exerts antiapoptotic, antiexcitotoxic, anti-inflammatory effects and promotes mitochondrial functions in animals with cerebral ischemia. Given that melatonin shows almost no toxicity to humans and possesses multifaceted protective capacity against cerebral ischemia, it is valuable to consider using melatonin in clinical trials on patients suffering from stroke.Keywords: cerebral ischemia, melatonin, stroke, neuroprotection
format	article
author	Hsiao-Wen Lin E-Jian Lee
author_facet	Hsiao-Wen Lin E-Jian Lee
author_sort	Hsiao-Wen Lin
title	Effects of melatonin in experimental stroke models in acute, sub-acute, and chronic stages
title_short	Effects of melatonin in experimental stroke models in acute, sub-acute, and chronic stages
title_full	Effects of melatonin in experimental stroke models in acute, sub-acute, and chronic stages
title_fullStr	Effects of melatonin in experimental stroke models in acute, sub-acute, and chronic stages
title_full_unstemmed	Effects of melatonin in experimental stroke models in acute, sub-acute, and chronic stages
title_sort	effects of melatonin in experimental stroke models in acute, sub-acute, and chronic stages
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/6fd5d1a077bf435ea9009057bda51f9e
work_keys_str_mv	AT hsiaowenlin effectsofmelatonininexperimentalstrokemodelsinacutesubacuteandchronicstages AT ejianlee effectsofmelatonininexperimentalstrokemodelsinacutesubacuteandchronicstages
_version_	1718401603056173056

Effects of melatonin in experimental stroke models in acute, sub-acute, and chronic stages

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