Neurovascular imaging with QUTE-CE MRI in APOE4 rats reveals early vascular abnormalities.
Cerebrovascular abnormality is linked to Alzheimer's disease and related dementias (ADRDs). ApoE-Ɛ4 (APOE4) is known to play a critical role in neurovascular dysfunction, however current medical imaging technologies are limited in quantification. This cross-sectional study tested the feasibilit...
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2021
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oai:doaj.org-article:6fd6878838654be6add5ef9afa96e68c2021-12-02T20:19:24ZNeurovascular imaging with QUTE-CE MRI in APOE4 rats reveals early vascular abnormalities.1932-620310.1371/journal.pone.0256749https://doaj.org/article/6fd6878838654be6add5ef9afa96e68c2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256749https://doaj.org/toc/1932-6203Cerebrovascular abnormality is linked to Alzheimer's disease and related dementias (ADRDs). ApoE-Ɛ4 (APOE4) is known to play a critical role in neurovascular dysfunction, however current medical imaging technologies are limited in quantification. This cross-sectional study tested the feasibility of a recently established imaging modality, quantitative ultra-short time-to-echo contrast-enhanced magnetic resonance imaging (QUTE-CE MRI), to identify small vessel abnormality early in development of human APOE4 knock-in female rat (TGRA8960) animal model. At 8 months, 48.3% of the brain volume was found to have significant signal increase (75/173 anatomically segmented regions; q<0.05 for multiple comparisons). Notably, vascular abnormality was detected in the tri-synaptic circuit, cerebellum, and amygdala, all of which are known to functionally decline throughout AD pathology and have implications in learning and memory. The detected abnormality quantified with QUTE-CE MRI is likely a result of hyper-vascularization, but may also be partly, or wholly, due to contributions from blood-brain-barrier leakage. Further exploration with histological validation is warranted to verify the pathological cause. Regardless, these results indicate that QUTE-CE MRI can detect neurovascular dysfunction with high sensitivity with APOE4 and may be helpful to provide new insights into health and disease.Joshua LeastonCraig F FerrisPraveen KulkarniDharshan ChandramohanAnne L van de VenJu QiaoLiam TimmsJorge SepulcreGeorges El FakhriChao MaMarc D NormandinCodi GharagouzlooPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256749 (2021) |
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Medicine R Science Q |
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Medicine R Science Q Joshua Leaston Craig F Ferris Praveen Kulkarni Dharshan Chandramohan Anne L van de Ven Ju Qiao Liam Timms Jorge Sepulcre Georges El Fakhri Chao Ma Marc D Normandin Codi Gharagouzloo Neurovascular imaging with QUTE-CE MRI in APOE4 rats reveals early vascular abnormalities. |
| description |
Cerebrovascular abnormality is linked to Alzheimer's disease and related dementias (ADRDs). ApoE-Ɛ4 (APOE4) is known to play a critical role in neurovascular dysfunction, however current medical imaging technologies are limited in quantification. This cross-sectional study tested the feasibility of a recently established imaging modality, quantitative ultra-short time-to-echo contrast-enhanced magnetic resonance imaging (QUTE-CE MRI), to identify small vessel abnormality early in development of human APOE4 knock-in female rat (TGRA8960) animal model. At 8 months, 48.3% of the brain volume was found to have significant signal increase (75/173 anatomically segmented regions; q<0.05 for multiple comparisons). Notably, vascular abnormality was detected in the tri-synaptic circuit, cerebellum, and amygdala, all of which are known to functionally decline throughout AD pathology and have implications in learning and memory. The detected abnormality quantified with QUTE-CE MRI is likely a result of hyper-vascularization, but may also be partly, or wholly, due to contributions from blood-brain-barrier leakage. Further exploration with histological validation is warranted to verify the pathological cause. Regardless, these results indicate that QUTE-CE MRI can detect neurovascular dysfunction with high sensitivity with APOE4 and may be helpful to provide new insights into health and disease. |
| format |
article |
| author |
Joshua Leaston Craig F Ferris Praveen Kulkarni Dharshan Chandramohan Anne L van de Ven Ju Qiao Liam Timms Jorge Sepulcre Georges El Fakhri Chao Ma Marc D Normandin Codi Gharagouzloo |
| author_facet |
Joshua Leaston Craig F Ferris Praveen Kulkarni Dharshan Chandramohan Anne L van de Ven Ju Qiao Liam Timms Jorge Sepulcre Georges El Fakhri Chao Ma Marc D Normandin Codi Gharagouzloo |
| author_sort |
Joshua Leaston |
| title |
Neurovascular imaging with QUTE-CE MRI in APOE4 rats reveals early vascular abnormalities. |
| title_short |
Neurovascular imaging with QUTE-CE MRI in APOE4 rats reveals early vascular abnormalities. |
| title_full |
Neurovascular imaging with QUTE-CE MRI in APOE4 rats reveals early vascular abnormalities. |
| title_fullStr |
Neurovascular imaging with QUTE-CE MRI in APOE4 rats reveals early vascular abnormalities. |
| title_full_unstemmed |
Neurovascular imaging with QUTE-CE MRI in APOE4 rats reveals early vascular abnormalities. |
| title_sort |
neurovascular imaging with qute-ce mri in apoe4 rats reveals early vascular abnormalities. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/6fd6878838654be6add5ef9afa96e68c |
| work_keys_str_mv |
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| _version_ |
1718374231584014336 |