Size-Adjustable Nano-Drug Delivery Systems for Enhanced Tumor Retention and Penetration

Abstract Over the past decades, nano-drug delivery systems have shown great potential in improving tumor treatment. And the controllability and design flexibility of nanoparticles endow them a broad development space. The particle size is one of the most important factors affecting the potency of na...

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Autores principales:	Miao Deng, Jing-Dong Rao, Rong Guo, Man Li, Qin He
Formato:	article
Lenguaje:	EN
Publicado:	Georg Thieme Verlag KG 2021
Materias:	size-adjustable nano-drug delivery systems stimuli-responsive tumor retention tumor penetration Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/6fdccbb8c613487aba95568ee2ed38f5
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spelling	oai:doaj.org-article:6fdccbb8c613487aba95568ee2ed38f52021-11-23T00:03:14ZSize-Adjustable Nano-Drug Delivery Systems for Enhanced Tumor Retention and Penetration2628-50882628-509610.1055/s-0041-1736474https://doaj.org/article/6fdccbb8c613487aba95568ee2ed38f52021-11-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1736474https://doaj.org/toc/2628-5088https://doaj.org/toc/2628-5096Abstract Over the past decades, nano-drug delivery systems have shown great potential in improving tumor treatment. And the controllability and design flexibility of nanoparticles endow them a broad development space. The particle size is one of the most important factors affecting the potency of nano-drug delivery systems. Large-size (100–200 nm) nanoparticles are more conducive to long circulation and tumor retention, but have poor tumor penetration; small-size (<50 nm) nanoparticles can deeply penetrate tumor but are easily cleared. Most of the current fixed-size nanoparticles are difficult to balance the retention and penetration, while the proposal of size-adjustable nano-drug delivery systems offers a solution to this paradox. Many endogenous and exogenous stimuli, such as acidic pH, upregulated enzymes, temperature, light, catalysts, redox conditions, and reactive oxygen species, can trigger the in situ transformation of nanoparticles based on protonation, hydrolysis, click reaction, phase transition, photoisomerization, redox reaction, etc. In this review, we summarize the principles and applications of stimuli-responsive size-adjustable strategies, including size-enlargement strategies and size-shrinkage strategies. We also propose the challenges faced by size-adjustable nano-drug delivery systems, hoping to promote the development of this strategy.Miao DengJing-Dong RaoRong GuoMan LiQin HeGeorg Thieme Verlag KGarticlesize-adjustablenano-drug delivery systemsstimuli-responsivetumor retentiontumor penetrationPharmacy and materia medicaRS1-441ENPharmaceutical Fronts (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	size-adjustable nano-drug delivery systems stimuli-responsive tumor retention tumor penetration Pharmacy and materia medica RS1-441
spellingShingle	size-adjustable nano-drug delivery systems stimuli-responsive tumor retention tumor penetration Pharmacy and materia medica RS1-441 Miao Deng Jing-Dong Rao Rong Guo Man Li Qin He Size-Adjustable Nano-Drug Delivery Systems for Enhanced Tumor Retention and Penetration
description	Abstract Over the past decades, nano-drug delivery systems have shown great potential in improving tumor treatment. And the controllability and design flexibility of nanoparticles endow them a broad development space. The particle size is one of the most important factors affecting the potency of nano-drug delivery systems. Large-size (100–200 nm) nanoparticles are more conducive to long circulation and tumor retention, but have poor tumor penetration; small-size (<50 nm) nanoparticles can deeply penetrate tumor but are easily cleared. Most of the current fixed-size nanoparticles are difficult to balance the retention and penetration, while the proposal of size-adjustable nano-drug delivery systems offers a solution to this paradox. Many endogenous and exogenous stimuli, such as acidic pH, upregulated enzymes, temperature, light, catalysts, redox conditions, and reactive oxygen species, can trigger the in situ transformation of nanoparticles based on protonation, hydrolysis, click reaction, phase transition, photoisomerization, redox reaction, etc. In this review, we summarize the principles and applications of stimuli-responsive size-adjustable strategies, including size-enlargement strategies and size-shrinkage strategies. We also propose the challenges faced by size-adjustable nano-drug delivery systems, hoping to promote the development of this strategy.
format	article
author	Miao Deng Jing-Dong Rao Rong Guo Man Li Qin He
author_facet	Miao Deng Jing-Dong Rao Rong Guo Man Li Qin He
author_sort	Miao Deng
title	Size-Adjustable Nano-Drug Delivery Systems for Enhanced Tumor Retention and Penetration
title_short	Size-Adjustable Nano-Drug Delivery Systems for Enhanced Tumor Retention and Penetration
title_full	Size-Adjustable Nano-Drug Delivery Systems for Enhanced Tumor Retention and Penetration
title_fullStr	Size-Adjustable Nano-Drug Delivery Systems for Enhanced Tumor Retention and Penetration
title_full_unstemmed	Size-Adjustable Nano-Drug Delivery Systems for Enhanced Tumor Retention and Penetration
title_sort	size-adjustable nano-drug delivery systems for enhanced tumor retention and penetration
publisher	Georg Thieme Verlag KG
publishDate	2021
url	https://doaj.org/article/6fdccbb8c613487aba95568ee2ed38f5
work_keys_str_mv	AT miaodeng sizeadjustablenanodrugdeliverysystemsforenhancedtumorretentionandpenetration AT jingdongrao sizeadjustablenanodrugdeliverysystemsforenhancedtumorretentionandpenetration AT rongguo sizeadjustablenanodrugdeliverysystemsforenhancedtumorretentionandpenetration AT manli sizeadjustablenanodrugdeliverysystemsforenhancedtumorretentionandpenetration AT qinhe sizeadjustablenanodrugdeliverysystemsforenhancedtumorretentionandpenetration
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Size-Adjustable Nano-Drug Delivery Systems for Enhanced Tumor Retention and Penetration

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