Real-World Treatment Patterns and Outcomes from an Electronic Medical Records Database for Patients with Rheumatoid Arthritis Treated with Repository Corticotropin Injection

Kyle Hayes,1 Mary P Panaccio,1 Parul Houston,1 John Niewoehner,1 Mohammed Fahim,2 George J Wan,1 Bhavna Dhillon3 1Mallinckrodt Pharmaceuticals, Hampton, NJ, USA; 2KMK Consulting, Morristown, NJ, USA; 3United Rheumatology, Hauppauge, NY, USACorrespondence: Kyle HayesMallinckrodt Pharmaceuticals, Hamp...

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Autores principales:	Hayes K, Panaccio MP, Houston P, Niewoehner J, Fahim M, Wan GJ, Dhillon B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	acthar gel dmards real-world evidence rheumatoid arthritis repository corticotropin injection rci united rheumatology database Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/6fdd09333fb84fee8d81d9748795ac9c
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spelling	oai:doaj.org-article:6fdd09333fb84fee8d81d9748795ac9c2021-12-02T17:57:53ZReal-World Treatment Patterns and Outcomes from an Electronic Medical Records Database for Patients with Rheumatoid Arthritis Treated with Repository Corticotropin Injection1179-156Xhttps://doaj.org/article/6fdd09333fb84fee8d81d9748795ac9c2021-10-01T00:00:00Zhttps://www.dovepress.com/real-world-treatment-patterns-and-outcomes-from-an-electronic-medical--peer-reviewed-fulltext-article-OARRRhttps://doaj.org/toc/1179-156XKyle Hayes,1 Mary P Panaccio,1 Parul Houston,1 John Niewoehner,1 Mohammed Fahim,2 George J Wan,1 Bhavna Dhillon3 1Mallinckrodt Pharmaceuticals, Hampton, NJ, USA; 2KMK Consulting, Morristown, NJ, USA; 3United Rheumatology, Hauppauge, NY, USACorrespondence: Kyle HayesMallinckrodt Pharmaceuticals, Hampton, NJ, USATel +1 314-393-3531Email kyle.hayes@mnk.comPurpose: Repository corticotropin injection (RCI; Acthar® Gel) is a naturally sourced mixture of adrenocorticotropic hormone analogs and other pituitary peptides that exerts anti-inflammatory and immunomodulatory properties via melanocortin receptors. RCI is approved as a short-term adjunctive therapy for rheumatoid arthritis (RA) and is typically used in patients with refractory RA. The objective of this study was to describe real-world outcomes of RA patients treated with RCI by retrospective analysis of an electronic medical records (EMR) database.Patients and Methods: EMR data were obtained from the United Rheumatology-Normal Integrated Community Evidence (UR-NICETM) data repository for patients who used RCI for the treatment of RA. Demographics, comorbidities, disease history, medications, and laboratory evaluations 365 days prior to and 365 days after initiation of RCI were examined.Results: The patient cohort was predominantly White females with a mean age of 60 years and high RA activity prior to RCI therapy. Clinical measures of disease severity indicated that patients had high RA activity before starting RCI therapy. Clinical Disease Activity Index (CDAI) scores were significantly reduced 365 days post-initiation of RCI. Swollen and tender joint counts and patient-reported outcomes, including Routine Assessment of Patient Index Data 3 (RAPID3), Physician Global Assessment, and patient assessment of pain severity were also significantly lower. The number of patients taking conventional synthetic (cs) disease-modifying antirheumatic drugs (DMARDs), biologic (b) DMARDs, nonsteroidal anti-inflammatory drugs (NSAIDS), and opioids decreased, as did the number of drugs tried within each class for csDMARDs, bDMARDs, NSAIDs, and glucocorticoids.Conclusions: These findings suggest that RCI significantly improves clinical outcomes of RA and decreases the need for concomitant medications for up to 1 year following initiation of therapy. The study provides valuable insights into the use of RCI and management of these difficult-to-treat RA patients during routine clinical practice.Keywords: Acthar Gel, DMARDs, real-world evidence, rheumatoid arthritis, repository corticotropin injection, RCI, United Rheumatology databaseHayes KPanaccio MPHouston PNiewoehner JFahim MWan GJDhillon BDove Medical Pressarticleacthar geldmardsreal-world evidencerheumatoid arthritisrepository corticotropin injectionrciunited rheumatology databaseDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 13, Pp 315-323 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acthar gel dmards real-world evidence rheumatoid arthritis repository corticotropin injection rci united rheumatology database Diseases of the musculoskeletal system RC925-935
spellingShingle	acthar gel dmards real-world evidence rheumatoid arthritis repository corticotropin injection rci united rheumatology database Diseases of the musculoskeletal system RC925-935 Hayes K Panaccio MP Houston P Niewoehner J Fahim M Wan GJ Dhillon B Real-World Treatment Patterns and Outcomes from an Electronic Medical Records Database for Patients with Rheumatoid Arthritis Treated with Repository Corticotropin Injection
description	Kyle Hayes,1 Mary P Panaccio,1 Parul Houston,1 John Niewoehner,1 Mohammed Fahim,2 George J Wan,1 Bhavna Dhillon3 1Mallinckrodt Pharmaceuticals, Hampton, NJ, USA; 2KMK Consulting, Morristown, NJ, USA; 3United Rheumatology, Hauppauge, NY, USACorrespondence: Kyle HayesMallinckrodt Pharmaceuticals, Hampton, NJ, USATel +1 314-393-3531Email kyle.hayes@mnk.comPurpose: Repository corticotropin injection (RCI; Acthar® Gel) is a naturally sourced mixture of adrenocorticotropic hormone analogs and other pituitary peptides that exerts anti-inflammatory and immunomodulatory properties via melanocortin receptors. RCI is approved as a short-term adjunctive therapy for rheumatoid arthritis (RA) and is typically used in patients with refractory RA. The objective of this study was to describe real-world outcomes of RA patients treated with RCI by retrospective analysis of an electronic medical records (EMR) database.Patients and Methods: EMR data were obtained from the United Rheumatology-Normal Integrated Community Evidence (UR-NICETM) data repository for patients who used RCI for the treatment of RA. Demographics, comorbidities, disease history, medications, and laboratory evaluations 365 days prior to and 365 days after initiation of RCI were examined.Results: The patient cohort was predominantly White females with a mean age of 60 years and high RA activity prior to RCI therapy. Clinical measures of disease severity indicated that patients had high RA activity before starting RCI therapy. Clinical Disease Activity Index (CDAI) scores were significantly reduced 365 days post-initiation of RCI. Swollen and tender joint counts and patient-reported outcomes, including Routine Assessment of Patient Index Data 3 (RAPID3), Physician Global Assessment, and patient assessment of pain severity were also significantly lower. The number of patients taking conventional synthetic (cs) disease-modifying antirheumatic drugs (DMARDs), biologic (b) DMARDs, nonsteroidal anti-inflammatory drugs (NSAIDS), and opioids decreased, as did the number of drugs tried within each class for csDMARDs, bDMARDs, NSAIDs, and glucocorticoids.Conclusions: These findings suggest that RCI significantly improves clinical outcomes of RA and decreases the need for concomitant medications for up to 1 year following initiation of therapy. The study provides valuable insights into the use of RCI and management of these difficult-to-treat RA patients during routine clinical practice.Keywords: Acthar Gel, DMARDs, real-world evidence, rheumatoid arthritis, repository corticotropin injection, RCI, United Rheumatology database
format	article
author	Hayes K Panaccio MP Houston P Niewoehner J Fahim M Wan GJ Dhillon B
author_facet	Hayes K Panaccio MP Houston P Niewoehner J Fahim M Wan GJ Dhillon B
author_sort	Hayes K
title	Real-World Treatment Patterns and Outcomes from an Electronic Medical Records Database for Patients with Rheumatoid Arthritis Treated with Repository Corticotropin Injection
title_short	Real-World Treatment Patterns and Outcomes from an Electronic Medical Records Database for Patients with Rheumatoid Arthritis Treated with Repository Corticotropin Injection
title_full	Real-World Treatment Patterns and Outcomes from an Electronic Medical Records Database for Patients with Rheumatoid Arthritis Treated with Repository Corticotropin Injection
title_fullStr	Real-World Treatment Patterns and Outcomes from an Electronic Medical Records Database for Patients with Rheumatoid Arthritis Treated with Repository Corticotropin Injection
title_full_unstemmed	Real-World Treatment Patterns and Outcomes from an Electronic Medical Records Database for Patients with Rheumatoid Arthritis Treated with Repository Corticotropin Injection
title_sort	real-world treatment patterns and outcomes from an electronic medical records database for patients with rheumatoid arthritis treated with repository corticotropin injection
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/6fdd09333fb84fee8d81d9748795ac9c
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Real-World Treatment Patterns and Outcomes from an Electronic Medical Records Database for Patients with Rheumatoid Arthritis Treated with Repository Corticotropin Injection

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