Increased anxiety in offspring reared by circadian Clock mutant mice.

The maternal care that offspring receive from their mothers early in life influences the offspring's development of emotional behavior in adulthood. Here we found that offspring reared by circadian clock-impaired mice show elevated anxiety-related behavior. Clock mutant mice harboring a mutatio...

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Autores principales:	Hiroko Koizumi, Nobuhiro Kurabayashi, Yuto Watanabe, Kamon Sanada
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6fdec458e76f4efa9d462f2cf4a3c5b5
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spelling	oai:doaj.org-article:6fdec458e76f4efa9d462f2cf4a3c5b52021-11-18T07:42:04ZIncreased anxiety in offspring reared by circadian Clock mutant mice.1932-620310.1371/journal.pone.0066021https://doaj.org/article/6fdec458e76f4efa9d462f2cf4a3c5b52013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23776596/?tool=EBIhttps://doaj.org/toc/1932-6203The maternal care that offspring receive from their mothers early in life influences the offspring's development of emotional behavior in adulthood. Here we found that offspring reared by circadian clock-impaired mice show elevated anxiety-related behavior. Clock mutant mice harboring a mutation in Clock, a key component of the molecular circadian clock, display altered daily patterns of nursing behavior that is fragmented during the light period, instead of long bouts of nursing behavior in wild-type mice. Adult wild-type offspring fostered by Clock mutant mice exhibit increased anxiety-related behavior. This is coupled with reduced levels of brain serotonin at postnatal day 14, whose homeostasis during the early postnatal period is critical for normal emotional behavior in adulthood. Together, disruption of the circadian clock in mothers has an adverse impact on establishing normal anxiety levels in offspring, which may increase their risk of developing anxiety disorders.Hiroko KoizumiNobuhiro KurabayashiYuto WatanabeKamon SanadaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e66021 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hiroko Koizumi Nobuhiro Kurabayashi Yuto Watanabe Kamon Sanada Increased anxiety in offspring reared by circadian Clock mutant mice.
description	The maternal care that offspring receive from their mothers early in life influences the offspring's development of emotional behavior in adulthood. Here we found that offspring reared by circadian clock-impaired mice show elevated anxiety-related behavior. Clock mutant mice harboring a mutation in Clock, a key component of the molecular circadian clock, display altered daily patterns of nursing behavior that is fragmented during the light period, instead of long bouts of nursing behavior in wild-type mice. Adult wild-type offspring fostered by Clock mutant mice exhibit increased anxiety-related behavior. This is coupled with reduced levels of brain serotonin at postnatal day 14, whose homeostasis during the early postnatal period is critical for normal emotional behavior in adulthood. Together, disruption of the circadian clock in mothers has an adverse impact on establishing normal anxiety levels in offspring, which may increase their risk of developing anxiety disorders.
format	article
author	Hiroko Koizumi Nobuhiro Kurabayashi Yuto Watanabe Kamon Sanada
author_facet	Hiroko Koizumi Nobuhiro Kurabayashi Yuto Watanabe Kamon Sanada
author_sort	Hiroko Koizumi
title	Increased anxiety in offspring reared by circadian Clock mutant mice.
title_short	Increased anxiety in offspring reared by circadian Clock mutant mice.
title_full	Increased anxiety in offspring reared by circadian Clock mutant mice.
title_fullStr	Increased anxiety in offspring reared by circadian Clock mutant mice.
title_full_unstemmed	Increased anxiety in offspring reared by circadian Clock mutant mice.
title_sort	increased anxiety in offspring reared by circadian clock mutant mice.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/6fdec458e76f4efa9d462f2cf4a3c5b5
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Increased anxiety in offspring reared by circadian Clock mutant mice.

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