Non-IG aberrations of FOXP1 in B-cell malignancies lead to an aberrant expression of N-truncated isoforms of FOXP1.

Non-IG aberrations of FOXP1 in B-cell malignancies lead to an aberrant expression of N-truncated isoforms of FOXP1.

The transcription factor FOXP1 is implicated in the pathogenesis of B-cell lymphomas through chromosomal translocations involving either immunoglobulin heavy chain (IGH) locus or non-IG sequences. The former translocation, t(3;14)(p13;q32), results in dysregulated expression of FOXP1 juxtaposed with...

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Main Authors: Leila Rouhigharabaei, Julio Finalet Ferreiro, Thomas Tousseyn, Jo-Anne van der Krogt, Natalie Put, Eugenia Haralambieva, Carlos Graux, Brigitte Maes, Carmen Vicente, Peter Vandenberghe, Jan Cools, Iwona Wlodarska
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/6fdfd1660fbb45909fdf610a1b8dc7aa
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