Additional partial hepatectomy at the time of portal vein ligation accelerates the regeneration of the future liver remnant

Abstract Portal vein ligation (PVL) has been adopted to induce hypertrophy of the future liver remnant (FLR) in patients with primarily irresectable liver tumor. However, regeneration of the FLR is not always sufficient to allow curative resection of the portally-deprived tumor-bearing liver lobe. W...

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Autores principales:	Chuanfeng Hua, Weiwei Wei, Tianjiao Zhang, Fengming Xu, Olaf Dirsch, André Homeyer, Utz Settmacher, Uta Dahmen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6fdff7da51ad485391a7d31594b5606b
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spelling	oai:doaj.org-article:6fdff7da51ad485391a7d31594b5606b2021-12-02T15:57:21ZAdditional partial hepatectomy at the time of portal vein ligation accelerates the regeneration of the future liver remnant10.1038/s41598-021-90819-x2045-2322https://doaj.org/article/6fdff7da51ad485391a7d31594b5606b2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90819-xhttps://doaj.org/toc/2045-2322Abstract Portal vein ligation (PVL) has been adopted to induce hypertrophy of the future liver remnant (FLR) in patients with primarily irresectable liver tumor. However, regeneration of the FLR is not always sufficient to allow curative resection of the portally-deprived tumor-bearing liver lobe. We hypothesize that simultaneous hepatectomy (PHx) and PVL augments regeneration of the FLR and that the effect is related to the extent of the additional resection. Seventy-two Lewis rats were enrolled into 3 groups: 20%PVL + 70%PHx; 70%PVL + 20%PHx; 90%PVL. Animals were observed for 1, 2, 3 and 7 days postoperatively (n = 6/time point). Liver enzymes, caudate liver/body-weight-ratio, BrdU-proliferation-index (PI), proliferating-cell-nuclear-antigen (PCNA)-mRNA-expression level and autophagy-related-proteins were evaluated. Compared with 90% PVL, additional PHx induced significantly more hypertrophy during the observation time, which was confirmed by significantly higher PI and higher level of PCNA-mRNA expression. Similarly, the additional PHx induced more autophagy in the FLR compared with PVL alone. However, both effects were not clearly related to the extent of additional resection. Additional resection augmented liver regeneration and autophagy substantially compared with PVL alone. Therefore, we concluded that autophagy might play a critical role in regulating hepatocyte proliferation and the size of the FLR after simultaneous PVL + PHx.Chuanfeng HuaWeiwei WeiTianjiao ZhangFengming XuOlaf DirschAndré HomeyerUtz SettmacherUta DahmenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chuanfeng Hua Weiwei Wei Tianjiao Zhang Fengming Xu Olaf Dirsch André Homeyer Utz Settmacher Uta Dahmen Additional partial hepatectomy at the time of portal vein ligation accelerates the regeneration of the future liver remnant
description	Abstract Portal vein ligation (PVL) has been adopted to induce hypertrophy of the future liver remnant (FLR) in patients with primarily irresectable liver tumor. However, regeneration of the FLR is not always sufficient to allow curative resection of the portally-deprived tumor-bearing liver lobe. We hypothesize that simultaneous hepatectomy (PHx) and PVL augments regeneration of the FLR and that the effect is related to the extent of the additional resection. Seventy-two Lewis rats were enrolled into 3 groups: 20%PVL + 70%PHx; 70%PVL + 20%PHx; 90%PVL. Animals were observed for 1, 2, 3 and 7 days postoperatively (n = 6/time point). Liver enzymes, caudate liver/body-weight-ratio, BrdU-proliferation-index (PI), proliferating-cell-nuclear-antigen (PCNA)-mRNA-expression level and autophagy-related-proteins were evaluated. Compared with 90% PVL, additional PHx induced significantly more hypertrophy during the observation time, which was confirmed by significantly higher PI and higher level of PCNA-mRNA expression. Similarly, the additional PHx induced more autophagy in the FLR compared with PVL alone. However, both effects were not clearly related to the extent of additional resection. Additional resection augmented liver regeneration and autophagy substantially compared with PVL alone. Therefore, we concluded that autophagy might play a critical role in regulating hepatocyte proliferation and the size of the FLR after simultaneous PVL + PHx.
format	article
author	Chuanfeng Hua Weiwei Wei Tianjiao Zhang Fengming Xu Olaf Dirsch André Homeyer Utz Settmacher Uta Dahmen
author_facet	Chuanfeng Hua Weiwei Wei Tianjiao Zhang Fengming Xu Olaf Dirsch André Homeyer Utz Settmacher Uta Dahmen
author_sort	Chuanfeng Hua
title	Additional partial hepatectomy at the time of portal vein ligation accelerates the regeneration of the future liver remnant
title_short	Additional partial hepatectomy at the time of portal vein ligation accelerates the regeneration of the future liver remnant
title_full	Additional partial hepatectomy at the time of portal vein ligation accelerates the regeneration of the future liver remnant
title_fullStr	Additional partial hepatectomy at the time of portal vein ligation accelerates the regeneration of the future liver remnant
title_full_unstemmed	Additional partial hepatectomy at the time of portal vein ligation accelerates the regeneration of the future liver remnant
title_sort	additional partial hepatectomy at the time of portal vein ligation accelerates the regeneration of the future liver remnant
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6fdff7da51ad485391a7d31594b5606b
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Additional partial hepatectomy at the time of portal vein ligation accelerates the regeneration of the future liver remnant

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