The rodent object-in-context task: A systematic review and meta-analysis of important variables.

Environmental information plays an important role in remembering events. Information about stable aspects of the environment (here referred to as 'context') and the event are combined by the hippocampal system and stored as context-dependent memory. In rodents (such as rats and mice), cont...

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Autores principales:	Milou S C Sep, Marijn Vellinga, R Angela Sarabdjitsingh, Marian Joëls
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6fe255eaf9bc4a169b1d482cc8f65a51
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spelling	oai:doaj.org-article:6fe255eaf9bc4a169b1d482cc8f65a512021-12-02T20:05:01ZThe rodent object-in-context task: A systematic review and meta-analysis of important variables.1932-620310.1371/journal.pone.0249102https://doaj.org/article/6fe255eaf9bc4a169b1d482cc8f65a512021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0249102https://doaj.org/toc/1932-6203Environmental information plays an important role in remembering events. Information about stable aspects of the environment (here referred to as 'context') and the event are combined by the hippocampal system and stored as context-dependent memory. In rodents (such as rats and mice), context-dependent memory is often investigated with the object-in-context task. However, the implementation and interpretation of this task varies considerably across studies. This variation hampers the comparison between studies and-for those who design a new experiment or carry out pilot experiments-the estimation of whether observed behavior is within the expected range. Also, it is currently unclear which of the variables critically influence the outcome of the task. To address these issues, we carried out a preregistered systematic review (PROSPERO CRD42020191340) and provide an up-to-date overview of the animal-, task-, and protocol-related variations in the object-in-context task for rodents. Using a data-driven explorative meta-analysis we next identified critical factors influencing the outcome of this task, such as sex, testbox size and the delay between the learning trials. Based on these observations we provide recommendations on sex, strain, prior arousal, context (size, walls, shape, etc.) and timing (habituation, learning, and memory phase) to create more consensus in the set-up, procedure, and interpretation of the object-in-context task for rodents. This could contribute to a more robust and evidence-based design in future animal experiments.Milou S C SepMarijn VellingaR Angela SarabdjitsinghMarian JoëlsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0249102 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Milou S C Sep Marijn Vellinga R Angela Sarabdjitsingh Marian Joëls The rodent object-in-context task: A systematic review and meta-analysis of important variables.
description	Environmental information plays an important role in remembering events. Information about stable aspects of the environment (here referred to as 'context') and the event are combined by the hippocampal system and stored as context-dependent memory. In rodents (such as rats and mice), context-dependent memory is often investigated with the object-in-context task. However, the implementation and interpretation of this task varies considerably across studies. This variation hampers the comparison between studies and-for those who design a new experiment or carry out pilot experiments-the estimation of whether observed behavior is within the expected range. Also, it is currently unclear which of the variables critically influence the outcome of the task. To address these issues, we carried out a preregistered systematic review (PROSPERO CRD42020191340) and provide an up-to-date overview of the animal-, task-, and protocol-related variations in the object-in-context task for rodents. Using a data-driven explorative meta-analysis we next identified critical factors influencing the outcome of this task, such as sex, testbox size and the delay between the learning trials. Based on these observations we provide recommendations on sex, strain, prior arousal, context (size, walls, shape, etc.) and timing (habituation, learning, and memory phase) to create more consensus in the set-up, procedure, and interpretation of the object-in-context task for rodents. This could contribute to a more robust and evidence-based design in future animal experiments.
format	article
author	Milou S C Sep Marijn Vellinga R Angela Sarabdjitsingh Marian Joëls
author_facet	Milou S C Sep Marijn Vellinga R Angela Sarabdjitsingh Marian Joëls
author_sort	Milou S C Sep
title	The rodent object-in-context task: A systematic review and meta-analysis of important variables.
title_short	The rodent object-in-context task: A systematic review and meta-analysis of important variables.
title_full	The rodent object-in-context task: A systematic review and meta-analysis of important variables.
title_fullStr	The rodent object-in-context task: A systematic review and meta-analysis of important variables.
title_full_unstemmed	The rodent object-in-context task: A systematic review and meta-analysis of important variables.
title_sort	rodent object-in-context task: a systematic review and meta-analysis of important variables.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/6fe255eaf9bc4a169b1d482cc8f65a51
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The rodent object-in-context task: A systematic review and meta-analysis of important variables.

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