Rotavirus A infection in pre- and post-vaccine period: Risk factors, genotypes distribution by vaccination status and age of children in Nampula Province, Northern Mozambique (2015-2019).

Mozambique introduced the monovalent rotavirus vaccine (Rotarix®, GSK Biologicals, Rixensart, Belgium) in September 2015. Previous analysis, showed that Nampula province continues reporting a high frequency of Rotavirus A (RVA) infection and the emergence of G9P[6], G9P[4] and G3P[4] genotypes. This...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Assucênio Chissaque, Adilson Fernando Loforte Bauhofer, Idalécia Cossa-Moiane, Ezequias Sitoe, Benilde Munlela, Eva Dora João, Jerónimo S Langa, Jorfélia José Chilaúle, Simone Salvador Boene, Marta Cassocera, Esperança Lourenço Guimarães, Timothy A Kellogg, Luzia Gonçalves, Nilsa de Deus
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
R
Q
Acceso en línea:https://doaj.org/article/6fe4467f05f842fa925f03ec7c1ca219
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:6fe4467f05f842fa925f03ec7c1ca219
record_format dspace
spelling oai:doaj.org-article:6fe4467f05f842fa925f03ec7c1ca2192021-12-02T20:19:38ZRotavirus A infection in pre- and post-vaccine period: Risk factors, genotypes distribution by vaccination status and age of children in Nampula Province, Northern Mozambique (2015-2019).1932-620310.1371/journal.pone.0255720https://doaj.org/article/6fe4467f05f842fa925f03ec7c1ca2192021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255720https://doaj.org/toc/1932-6203Mozambique introduced the monovalent rotavirus vaccine (Rotarix®, GSK Biologicals, Rixensart, Belgium) in September 2015. Previous analysis, showed that Nampula province continues reporting a high frequency of Rotavirus A (RVA) infection and the emergence of G9P[6], G9P[4] and G3P[4] genotypes. This analysis aimed to determine the RVA frequency; risk factors; genotype distribution by vaccination status and age between pre- and post-vaccine periods in children under-five years old with diarrhea in Nampula. A cross-sectional, hospital-based surveillance study was conducted in the Hospital Central de Nampula in Mozambique. Socio-demographic and clinical data were collected to assess factors related to RVA infection in both periods. Stool specimens were screened to detect RVA by ELISA, and positive samples were genotyped. Between 2015 (pre-vaccine period) and 2016-2019 (post-vaccine period), 614 stool specimens were collected and tested for RVA in which 34.9% (67/192) were positive in pre-vaccine period and 21.8% (92/422) in post-vaccine (p = 0.001). In the post-vaccine period, age, year, and contact with different animal species (chicken, duck, or multiple animals) were associated with RVA infection. RVA infection was higher in children partially vaccinated (40.7%, 11/27) followed by the fully vaccinated (29.3%, 56/191) and the unvaccinated (15.3%, 21/137) (p = 0.002). G1P[8] and G9P[4] were common in vaccinated children less than 12 months. The present analysis showed that RVA infection reduced slightly in the post-vaccine period, with a high proportion of infection and genotype diversity in children, under 12 months of age, vaccinated. Further research on factors associated with RVA infection on vaccinated compared to unvaccinated children and vaccination optimization should be done.Assucênio ChissaqueAdilson Fernando Loforte BauhoferIdalécia Cossa-MoianeEzequias SitoeBenilde MunlelaEva Dora JoãoJerónimo S LangaJorfélia José ChilaúleSimone Salvador BoeneMarta CassoceraEsperança Lourenço GuimarãesTimothy A KelloggLuzia GonçalvesNilsa de DeusPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255720 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Assucênio Chissaque
Adilson Fernando Loforte Bauhofer
Idalécia Cossa-Moiane
Ezequias Sitoe
Benilde Munlela
Eva Dora João
Jerónimo S Langa
Jorfélia José Chilaúle
Simone Salvador Boene
Marta Cassocera
Esperança Lourenço Guimarães
Timothy A Kellogg
Luzia Gonçalves
Nilsa de Deus
Rotavirus A infection in pre- and post-vaccine period: Risk factors, genotypes distribution by vaccination status and age of children in Nampula Province, Northern Mozambique (2015-2019).
description Mozambique introduced the monovalent rotavirus vaccine (Rotarix®, GSK Biologicals, Rixensart, Belgium) in September 2015. Previous analysis, showed that Nampula province continues reporting a high frequency of Rotavirus A (RVA) infection and the emergence of G9P[6], G9P[4] and G3P[4] genotypes. This analysis aimed to determine the RVA frequency; risk factors; genotype distribution by vaccination status and age between pre- and post-vaccine periods in children under-five years old with diarrhea in Nampula. A cross-sectional, hospital-based surveillance study was conducted in the Hospital Central de Nampula in Mozambique. Socio-demographic and clinical data were collected to assess factors related to RVA infection in both periods. Stool specimens were screened to detect RVA by ELISA, and positive samples were genotyped. Between 2015 (pre-vaccine period) and 2016-2019 (post-vaccine period), 614 stool specimens were collected and tested for RVA in which 34.9% (67/192) were positive in pre-vaccine period and 21.8% (92/422) in post-vaccine (p = 0.001). In the post-vaccine period, age, year, and contact with different animal species (chicken, duck, or multiple animals) were associated with RVA infection. RVA infection was higher in children partially vaccinated (40.7%, 11/27) followed by the fully vaccinated (29.3%, 56/191) and the unvaccinated (15.3%, 21/137) (p = 0.002). G1P[8] and G9P[4] were common in vaccinated children less than 12 months. The present analysis showed that RVA infection reduced slightly in the post-vaccine period, with a high proportion of infection and genotype diversity in children, under 12 months of age, vaccinated. Further research on factors associated with RVA infection on vaccinated compared to unvaccinated children and vaccination optimization should be done.
format article
author Assucênio Chissaque
Adilson Fernando Loforte Bauhofer
Idalécia Cossa-Moiane
Ezequias Sitoe
Benilde Munlela
Eva Dora João
Jerónimo S Langa
Jorfélia José Chilaúle
Simone Salvador Boene
Marta Cassocera
Esperança Lourenço Guimarães
Timothy A Kellogg
Luzia Gonçalves
Nilsa de Deus
author_facet Assucênio Chissaque
Adilson Fernando Loforte Bauhofer
Idalécia Cossa-Moiane
Ezequias Sitoe
Benilde Munlela
Eva Dora João
Jerónimo S Langa
Jorfélia José Chilaúle
Simone Salvador Boene
Marta Cassocera
Esperança Lourenço Guimarães
Timothy A Kellogg
Luzia Gonçalves
Nilsa de Deus
author_sort Assucênio Chissaque
title Rotavirus A infection in pre- and post-vaccine period: Risk factors, genotypes distribution by vaccination status and age of children in Nampula Province, Northern Mozambique (2015-2019).
title_short Rotavirus A infection in pre- and post-vaccine period: Risk factors, genotypes distribution by vaccination status and age of children in Nampula Province, Northern Mozambique (2015-2019).
title_full Rotavirus A infection in pre- and post-vaccine period: Risk factors, genotypes distribution by vaccination status and age of children in Nampula Province, Northern Mozambique (2015-2019).
title_fullStr Rotavirus A infection in pre- and post-vaccine period: Risk factors, genotypes distribution by vaccination status and age of children in Nampula Province, Northern Mozambique (2015-2019).
title_full_unstemmed Rotavirus A infection in pre- and post-vaccine period: Risk factors, genotypes distribution by vaccination status and age of children in Nampula Province, Northern Mozambique (2015-2019).
title_sort rotavirus a infection in pre- and post-vaccine period: risk factors, genotypes distribution by vaccination status and age of children in nampula province, northern mozambique (2015-2019).
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/6fe4467f05f842fa925f03ec7c1ca219
work_keys_str_mv AT assuceniochissaque rotavirusainfectioninpreandpostvaccineperiodriskfactorsgenotypesdistributionbyvaccinationstatusandageofchildreninnampulaprovincenorthernmozambique20152019
AT adilsonfernandolofortebauhofer rotavirusainfectioninpreandpostvaccineperiodriskfactorsgenotypesdistributionbyvaccinationstatusandageofchildreninnampulaprovincenorthernmozambique20152019
AT idaleciacossamoiane rotavirusainfectioninpreandpostvaccineperiodriskfactorsgenotypesdistributionbyvaccinationstatusandageofchildreninnampulaprovincenorthernmozambique20152019
AT ezequiassitoe rotavirusainfectioninpreandpostvaccineperiodriskfactorsgenotypesdistributionbyvaccinationstatusandageofchildreninnampulaprovincenorthernmozambique20152019
AT benildemunlela rotavirusainfectioninpreandpostvaccineperiodriskfactorsgenotypesdistributionbyvaccinationstatusandageofchildreninnampulaprovincenorthernmozambique20152019
AT evadorajoao rotavirusainfectioninpreandpostvaccineperiodriskfactorsgenotypesdistributionbyvaccinationstatusandageofchildreninnampulaprovincenorthernmozambique20152019
AT jeronimoslanga rotavirusainfectioninpreandpostvaccineperiodriskfactorsgenotypesdistributionbyvaccinationstatusandageofchildreninnampulaprovincenorthernmozambique20152019
AT jorfeliajosechilaule rotavirusainfectioninpreandpostvaccineperiodriskfactorsgenotypesdistributionbyvaccinationstatusandageofchildreninnampulaprovincenorthernmozambique20152019
AT simonesalvadorboene rotavirusainfectioninpreandpostvaccineperiodriskfactorsgenotypesdistributionbyvaccinationstatusandageofchildreninnampulaprovincenorthernmozambique20152019
AT martacassocera rotavirusainfectioninpreandpostvaccineperiodriskfactorsgenotypesdistributionbyvaccinationstatusandageofchildreninnampulaprovincenorthernmozambique20152019
AT esperancalourencoguimaraes rotavirusainfectioninpreandpostvaccineperiodriskfactorsgenotypesdistributionbyvaccinationstatusandageofchildreninnampulaprovincenorthernmozambique20152019
AT timothyakellogg rotavirusainfectioninpreandpostvaccineperiodriskfactorsgenotypesdistributionbyvaccinationstatusandageofchildreninnampulaprovincenorthernmozambique20152019
AT luziagoncalves rotavirusainfectioninpreandpostvaccineperiodriskfactorsgenotypesdistributionbyvaccinationstatusandageofchildreninnampulaprovincenorthernmozambique20152019
AT nilsadedeus rotavirusainfectioninpreandpostvaccineperiodriskfactorsgenotypesdistributionbyvaccinationstatusandageofchildreninnampulaprovincenorthernmozambique20152019
_version_ 1718374169538723840