The HIV co-receptor CCR5 regulates osteoclast function

The HIV co-receptor CCR5 regulates osteoclast function

CCR5 is a co-receptor for HIV, and loss of function is associated with lower incidence of HIV but also with bone-destructive diseases. Here the authors show that ablation of CCR5 impairs osteoclast function and improves resistance to osteoporosis in mouse models.

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Autores principales: Ji-Won Lee, Akiyoshi Hoshino, Kazuki Inoue, Takashi Saitou, Shunsuke Uehara, Yasuhiro Kobayashi, Satoshi Ueha, Kouji Matsushima, Akira Yamaguchi, Yuuki Imai, Tadahiro Iimura
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/6fe7e4dd266040a8baeee5dab56aa280
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spelling oai:doaj.org-article:6fe7e4dd266040a8baeee5dab56aa2802021-12-02T14:40:48ZThe HIV co-receptor CCR5 regulates osteoclast function10.1038/s41467-017-02368-52041-1723https://doaj.org/article/6fe7e4dd266040a8baeee5dab56aa2802017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02368-5https://doaj.org/toc/2041-1723CCR5 is a co-receptor for HIV, and loss of function is associated with lower incidence of HIV but also with bone-destructive diseases. Here the authors show that ablation of CCR5 impairs osteoclast function and improves resistance to osteoporosis in mouse models.Ji-Won LeeAkiyoshi HoshinoKazuki InoueTakashi SaitouShunsuke UeharaYasuhiro KobayashiSatoshi UehaKouji MatsushimaAkira YamaguchiYuuki ImaiTadahiro IimuraNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ji-Won Lee
Akiyoshi Hoshino
Kazuki Inoue
Takashi Saitou
Shunsuke Uehara
Yasuhiro Kobayashi
Satoshi Ueha
Kouji Matsushima
Akira Yamaguchi
Yuuki Imai
Tadahiro Iimura
The HIV co-receptor CCR5 regulates osteoclast function
description CCR5 is a co-receptor for HIV, and loss of function is associated with lower incidence of HIV but also with bone-destructive diseases. Here the authors show that ablation of CCR5 impairs osteoclast function and improves resistance to osteoporosis in mouse models.
format article
author Ji-Won Lee
Akiyoshi Hoshino
Kazuki Inoue
Takashi Saitou
Shunsuke Uehara
Yasuhiro Kobayashi
Satoshi Ueha
Kouji Matsushima
Akira Yamaguchi
Yuuki Imai
Tadahiro Iimura
author_facet Ji-Won Lee
Akiyoshi Hoshino
Kazuki Inoue
Takashi Saitou
Shunsuke Uehara
Yasuhiro Kobayashi
Satoshi Ueha
Kouji Matsushima
Akira Yamaguchi
Yuuki Imai
Tadahiro Iimura
author_sort Ji-Won Lee
title The HIV co-receptor CCR5 regulates osteoclast function
title_short The HIV co-receptor CCR5 regulates osteoclast function
title_full The HIV co-receptor CCR5 regulates osteoclast function
title_fullStr The HIV co-receptor CCR5 regulates osteoclast function
title_full_unstemmed The HIV co-receptor CCR5 regulates osteoclast function
title_sort hiv co-receptor ccr5 regulates osteoclast function
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/6fe7e4dd266040a8baeee5dab56aa280
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