EFFECT OF JNK MAPK ON THE REPAIR OF DAMAGED SKELETAL MUSCLE

Regeneration of muscles after injuries, as well as the development of methods that stimulate this process, is an important problem in medicine and biology. The objective of the study was to evaluate the effect of local blocking of mitogen-activated protein kinase (MAPK) activity of the JNK group (c-...

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Autores principales:	I. A. Shurygina, M. G. Shurygin
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2018
Materias:	jnk sp600125 Science Q
Acceso en línea:	https://doaj.org/article/6fe91035fdf74a2986de0ee64498b27c
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spelling	oai:doaj.org-article:6fe91035fdf74a2986de0ee64498b27c2021-11-23T06:14:41ZEFFECT OF JNK MAPK ON THE REPAIR OF DAMAGED SKELETAL MUSCLE2541-94202587-959610.29413/ABS.2018-3.5.20https://doaj.org/article/6fe91035fdf74a2986de0ee64498b27c2018-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/719https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Regeneration of muscles after injuries, as well as the development of methods that stimulate this process, is an important problem in medicine and biology. The objective of the study was to evaluate the effect of local blocking of mitogen-activated protein kinase (MAPK) activity of the JNK group (c-Jun N-terminal kinase) on the repair of muscle tissue. Materials and methods. The effect of the JNK MAPK SP600125 blocker on the repair of muscle tissue was studied on a model of a skin and muscle wound in Wistar rats. The main group (n = 30) was injected with a drug plate containing SP600125 with a slow release of the active substance, the control group (n = 30) – the plate without the active substance. The number of dividing myosatellites and muscle kidneys in the damage zone was estimated. Results. Experimental studies have shown that when using a drug plate containing a JNK SP600125 blocker with a slow release of the active substance, the number of dividing myosatellites and forming muscle kidneys in the injury zone of the muscle in the main group on the 7th, 14th and 30th days was significantly higher (p < 0.05) than in the control. Conclusion. Local blockade of JNK MAPK in the zone of muscle damage provides the ability to stimulate the repair of damaged skeletal muscle.I. A. ShuryginaM. G. ShuryginScientific Сentre for Family Health and Human Reproduction Problemsarticlejnksp600125ScienceQRUActa Biomedica Scientifica, Vol 3, Iss 5, Pp 137-140 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	jnk sp600125 Science Q
spellingShingle	jnk sp600125 Science Q I. A. Shurygina M. G. Shurygin EFFECT OF JNK MAPK ON THE REPAIR OF DAMAGED SKELETAL MUSCLE
description	Regeneration of muscles after injuries, as well as the development of methods that stimulate this process, is an important problem in medicine and biology. The objective of the study was to evaluate the effect of local blocking of mitogen-activated protein kinase (MAPK) activity of the JNK group (c-Jun N-terminal kinase) on the repair of muscle tissue. Materials and methods. The effect of the JNK MAPK SP600125 blocker on the repair of muscle tissue was studied on a model of a skin and muscle wound in Wistar rats. The main group (n = 30) was injected with a drug plate containing SP600125 with a slow release of the active substance, the control group (n = 30) – the plate without the active substance. The number of dividing myosatellites and muscle kidneys in the damage zone was estimated. Results. Experimental studies have shown that when using a drug plate containing a JNK SP600125 blocker with a slow release of the active substance, the number of dividing myosatellites and forming muscle kidneys in the injury zone of the muscle in the main group on the 7th, 14th and 30th days was significantly higher (p < 0.05) than in the control. Conclusion. Local blockade of JNK MAPK in the zone of muscle damage provides the ability to stimulate the repair of damaged skeletal muscle.
format	article
author	I. A. Shurygina M. G. Shurygin
author_facet	I. A. Shurygina M. G. Shurygin
author_sort	I. A. Shurygina
title	EFFECT OF JNK MAPK ON THE REPAIR OF DAMAGED SKELETAL MUSCLE
title_short	EFFECT OF JNK MAPK ON THE REPAIR OF DAMAGED SKELETAL MUSCLE
title_full	EFFECT OF JNK MAPK ON THE REPAIR OF DAMAGED SKELETAL MUSCLE
title_fullStr	EFFECT OF JNK MAPK ON THE REPAIR OF DAMAGED SKELETAL MUSCLE
title_full_unstemmed	EFFECT OF JNK MAPK ON THE REPAIR OF DAMAGED SKELETAL MUSCLE
title_sort	effect of jnk mapk on the repair of damaged skeletal muscle
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2018
url	https://doaj.org/article/6fe91035fdf74a2986de0ee64498b27c
work_keys_str_mv	AT iashurygina effectofjnkmapkontherepairofdamagedskeletalmuscle AT mgshurygin effectofjnkmapkontherepairofdamagedskeletalmuscle
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EFFECT OF JNK MAPK ON THE REPAIR OF DAMAGED SKELETAL MUSCLE

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