Protein Binding to Cis-Motifs in mRNAs Coding Sequence Is Common and Regulates Transcript Stability and the Rate of Translation

Protein binding to the non-coding regions of mRNAs is relatively well characterized and its functionality has been described in many examples. New results obtained by high-throughput methods indicate that binding to the coding sequence (CDS) by RNA-binding proteins is also quite common, but the func...

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Autores principales:	Ewa A. Grzybowska, Maciej Wakula
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	RNA-binding proteins coding sequence mammalian post-transcriptional gene expression Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6feae23f8c894cd4880f33a68e10b65e
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spelling	oai:doaj.org-article:6feae23f8c894cd4880f33a68e10b65e2021-11-25T17:08:48ZProtein Binding to Cis-Motifs in mRNAs Coding Sequence Is Common and Regulates Transcript Stability and the Rate of Translation10.3390/cells101129102073-4409https://doaj.org/article/6feae23f8c894cd4880f33a68e10b65e2021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2910https://doaj.org/toc/2073-4409Protein binding to the non-coding regions of mRNAs is relatively well characterized and its functionality has been described in many examples. New results obtained by high-throughput methods indicate that binding to the coding sequence (CDS) by RNA-binding proteins is also quite common, but the functions thereof are more obscure. As described in this review, CDS binding has a role in the regulation of mRNA stability, but it has also a more intriguing role in the regulation of translational efficiency. Global approaches, which suggest the significance of CDS binding along with specific examples of CDS-binding RBPs and their modes of action, are outlined here, pointing to the existence of a relatively less-known regulatory network controlling mRNA stability and translation on yet another level.Ewa A. GrzybowskaMaciej WakulaMDPI AGarticleRNA-binding proteinscoding sequencemammalian post-transcriptional gene expressionBiology (General)QH301-705.5ENCells, Vol 10, Iss 2910, p 2910 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	RNA-binding proteins coding sequence mammalian post-transcriptional gene expression Biology (General) QH301-705.5
spellingShingle	RNA-binding proteins coding sequence mammalian post-transcriptional gene expression Biology (General) QH301-705.5 Ewa A. Grzybowska Maciej Wakula Protein Binding to Cis-Motifs in mRNAs Coding Sequence Is Common and Regulates Transcript Stability and the Rate of Translation
description	Protein binding to the non-coding regions of mRNAs is relatively well characterized and its functionality has been described in many examples. New results obtained by high-throughput methods indicate that binding to the coding sequence (CDS) by RNA-binding proteins is also quite common, but the functions thereof are more obscure. As described in this review, CDS binding has a role in the regulation of mRNA stability, but it has also a more intriguing role in the regulation of translational efficiency. Global approaches, which suggest the significance of CDS binding along with specific examples of CDS-binding RBPs and their modes of action, are outlined here, pointing to the existence of a relatively less-known regulatory network controlling mRNA stability and translation on yet another level.
format	article
author	Ewa A. Grzybowska Maciej Wakula
author_facet	Ewa A. Grzybowska Maciej Wakula
author_sort	Ewa A. Grzybowska
title	Protein Binding to Cis-Motifs in mRNAs Coding Sequence Is Common and Regulates Transcript Stability and the Rate of Translation
title_short	Protein Binding to Cis-Motifs in mRNAs Coding Sequence Is Common and Regulates Transcript Stability and the Rate of Translation
title_full	Protein Binding to Cis-Motifs in mRNAs Coding Sequence Is Common and Regulates Transcript Stability and the Rate of Translation
title_fullStr	Protein Binding to Cis-Motifs in mRNAs Coding Sequence Is Common and Regulates Transcript Stability and the Rate of Translation
title_full_unstemmed	Protein Binding to Cis-Motifs in mRNAs Coding Sequence Is Common and Regulates Transcript Stability and the Rate of Translation
title_sort	protein binding to cis-motifs in mrnas coding sequence is common and regulates transcript stability and the rate of translation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6feae23f8c894cd4880f33a68e10b65e
work_keys_str_mv	AT ewaagrzybowska proteinbindingtocismotifsinmrnascodingsequenceiscommonandregulatestranscriptstabilityandtherateoftranslation AT maciejwakula proteinbindingtocismotifsinmrnascodingsequenceiscommonandregulatestranscriptstabilityandtherateoftranslation
_version_	1718412655398486016

Protein Binding to Cis-Motifs in mRNAs Coding Sequence Is Common and Regulates Transcript Stability and the Rate of Translation

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