Unraveling a tumor type-specific regulatory core underlying E2F1-mediated epithelial-mesenchymal transition to predict receptor protein signatures

Unraveling a tumor type-specific regulatory core underlying E2F1-mediated epithelial-mesenchymal transition to predict receptor protein signatures

Deregulation of E2F family transcription factors is associated with cancer progression and metastasis. Here, the authors construct a map of the regulatory network around the E2F family, and using gene expression profiles, identify tumour type-specific regulatory cores and receptor expression signatu...

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Autores principales: Faiz M. Khan, Stephan Marquardt, Shailendra K. Gupta, Susanne Knoll, Ulf Schmitz, Alf Spitschak, David Engelmann, Julio Vera, Olaf Wolkenhauer, Brigitte M. Pützer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/6feb9a206c964085ae20896ed0722b38
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spelling oai:doaj.org-article:6feb9a206c964085ae20896ed0722b382021-12-02T13:57:54ZUnraveling a tumor type-specific regulatory core underlying E2F1-mediated epithelial-mesenchymal transition to predict receptor protein signatures10.1038/s41467-017-00268-22041-1723https://doaj.org/article/6feb9a206c964085ae20896ed0722b382017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00268-2https://doaj.org/toc/2041-1723Deregulation of E2F family transcription factors is associated with cancer progression and metastasis. Here, the authors construct a map of the regulatory network around the E2F family, and using gene expression profiles, identify tumour type-specific regulatory cores and receptor expression signatures associated with epithelial-mesenchymal transition in bladder and breast cancer.Faiz M. KhanStephan MarquardtShailendra K. GuptaSusanne KnollUlf SchmitzAlf SpitschakDavid EngelmannJulio VeraOlaf WolkenhauerBrigitte M. PützerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Faiz M. Khan
Stephan Marquardt
Shailendra K. Gupta
Susanne Knoll
Ulf Schmitz
Alf Spitschak
David Engelmann
Julio Vera
Olaf Wolkenhauer
Brigitte M. Pützer
Unraveling a tumor type-specific regulatory core underlying E2F1-mediated epithelial-mesenchymal transition to predict receptor protein signatures
description Deregulation of E2F family transcription factors is associated with cancer progression and metastasis. Here, the authors construct a map of the regulatory network around the E2F family, and using gene expression profiles, identify tumour type-specific regulatory cores and receptor expression signatures associated with epithelial-mesenchymal transition in bladder and breast cancer.
format article
author Faiz M. Khan
Stephan Marquardt
Shailendra K. Gupta
Susanne Knoll
Ulf Schmitz
Alf Spitschak
David Engelmann
Julio Vera
Olaf Wolkenhauer
Brigitte M. Pützer
author_facet Faiz M. Khan
Stephan Marquardt
Shailendra K. Gupta
Susanne Knoll
Ulf Schmitz
Alf Spitschak
David Engelmann
Julio Vera
Olaf Wolkenhauer
Brigitte M. Pützer
author_sort Faiz M. Khan
title Unraveling a tumor type-specific regulatory core underlying E2F1-mediated epithelial-mesenchymal transition to predict receptor protein signatures
title_short Unraveling a tumor type-specific regulatory core underlying E2F1-mediated epithelial-mesenchymal transition to predict receptor protein signatures
title_full Unraveling a tumor type-specific regulatory core underlying E2F1-mediated epithelial-mesenchymal transition to predict receptor protein signatures
title_fullStr Unraveling a tumor type-specific regulatory core underlying E2F1-mediated epithelial-mesenchymal transition to predict receptor protein signatures
title_full_unstemmed Unraveling a tumor type-specific regulatory core underlying E2F1-mediated epithelial-mesenchymal transition to predict receptor protein signatures
title_sort unraveling a tumor type-specific regulatory core underlying e2f1-mediated epithelial-mesenchymal transition to predict receptor protein signatures
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/6feb9a206c964085ae20896ed0722b38
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