Decreased interhemispheric coordination in treatment-resistant depression: a resting-state fMRI study.

<h4>Background</h4>Previous studies have demonstrated that patients with treatment-resistant depression (TRD) and treatment-sensitive depression (TSD) differed at neural level. However, it remains unclear if these two subtypes of depression differ in the interhemispheric coordination. Th...

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Autores principales:	Wenbin Guo, Feng Liu, Zhimin Xue, Keming Gao, Zhening Liu, Changqing Xiao, Huafu Chen, Jingping Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6fec5c729fca4213b62b6cf9292efa76
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spelling	oai:doaj.org-article:6fec5c729fca4213b62b6cf9292efa762021-11-18T09:01:29ZDecreased interhemispheric coordination in treatment-resistant depression: a resting-state fMRI study.1932-620310.1371/journal.pone.0071368https://doaj.org/article/6fec5c729fca4213b62b6cf9292efa762013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23936504/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Previous studies have demonstrated that patients with treatment-resistant depression (TRD) and treatment-sensitive depression (TSD) differed at neural level. However, it remains unclear if these two subtypes of depression differ in the interhemispheric coordination. This study was undertaken for two purposes: (1) to explore the differences in interhemispheric coordination between these two subtypes by using the voxel-mirrored homotopic connectivity (VMHC) method; and (2) to determine if the difference of interhemispheric coordination can be used as a biomarker(s) to differentiate TRD from both TSD and healthy subjects (HS).<h4>Methods</h4>Twenty-three patients with TRD, 22 with TSD, and 19 HS participated in the study. Data of these participants were analyzed with the VMHC and seed-based functional connectivity (FC) approaches.<h4>Results</h4>Compared to the TSD group, the TRD group showed significantly lower VMHC values in the calcarine cortex, fusiform gyrus, hippocampus, superior temporal gyrus, middle cingulum, and precentral gyrus. Lower VMHC values were also observed in the TRD group in the calcarine cortex relative to the HS group. However, the TSD group had no significant change in VMHC value in any brain region compared to the HS group. Receiver operating characteristic curves (ROC) analysis revealed that the VMHC values in the calcarine cortex had discriminatory function distinguishing patients with TRD from patients with TSD as well as those participants in the HS group.<h4>Conclusions</h4>Lower VMHC values of patients with TRD relative to those with TSD and those in the HS group in the calcarine cortex appeared to be a unique feature for patients with TRD and it may be used as an imaging biomarker to separate patients with TRD from those with TSD or HS.Wenbin GuoFeng LiuZhimin XueKeming GaoZhening LiuChangqing XiaoHuafu ChenJingping ZhaoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e71368 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wenbin Guo Feng Liu Zhimin Xue Keming Gao Zhening Liu Changqing Xiao Huafu Chen Jingping Zhao Decreased interhemispheric coordination in treatment-resistant depression: a resting-state fMRI study.
description	<h4>Background</h4>Previous studies have demonstrated that patients with treatment-resistant depression (TRD) and treatment-sensitive depression (TSD) differed at neural level. However, it remains unclear if these two subtypes of depression differ in the interhemispheric coordination. This study was undertaken for two purposes: (1) to explore the differences in interhemispheric coordination between these two subtypes by using the voxel-mirrored homotopic connectivity (VMHC) method; and (2) to determine if the difference of interhemispheric coordination can be used as a biomarker(s) to differentiate TRD from both TSD and healthy subjects (HS).<h4>Methods</h4>Twenty-three patients with TRD, 22 with TSD, and 19 HS participated in the study. Data of these participants were analyzed with the VMHC and seed-based functional connectivity (FC) approaches.<h4>Results</h4>Compared to the TSD group, the TRD group showed significantly lower VMHC values in the calcarine cortex, fusiform gyrus, hippocampus, superior temporal gyrus, middle cingulum, and precentral gyrus. Lower VMHC values were also observed in the TRD group in the calcarine cortex relative to the HS group. However, the TSD group had no significant change in VMHC value in any brain region compared to the HS group. Receiver operating characteristic curves (ROC) analysis revealed that the VMHC values in the calcarine cortex had discriminatory function distinguishing patients with TRD from patients with TSD as well as those participants in the HS group.<h4>Conclusions</h4>Lower VMHC values of patients with TRD relative to those with TSD and those in the HS group in the calcarine cortex appeared to be a unique feature for patients with TRD and it may be used as an imaging biomarker to separate patients with TRD from those with TSD or HS.
format	article
author	Wenbin Guo Feng Liu Zhimin Xue Keming Gao Zhening Liu Changqing Xiao Huafu Chen Jingping Zhao
author_facet	Wenbin Guo Feng Liu Zhimin Xue Keming Gao Zhening Liu Changqing Xiao Huafu Chen Jingping Zhao
author_sort	Wenbin Guo
title	Decreased interhemispheric coordination in treatment-resistant depression: a resting-state fMRI study.
title_short	Decreased interhemispheric coordination in treatment-resistant depression: a resting-state fMRI study.
title_full	Decreased interhemispheric coordination in treatment-resistant depression: a resting-state fMRI study.
title_fullStr	Decreased interhemispheric coordination in treatment-resistant depression: a resting-state fMRI study.
title_full_unstemmed	Decreased interhemispheric coordination in treatment-resistant depression: a resting-state fMRI study.
title_sort	decreased interhemispheric coordination in treatment-resistant depression: a resting-state fmri study.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/6fec5c729fca4213b62b6cf9292efa76
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Decreased interhemispheric coordination in treatment-resistant depression: a resting-state fMRI study.

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