Evaluate the effect of different mmps inhibitors on adhesive physical properties of dental adhesives, bond strength and mmp substarte activity

Abstract We have evaluated and compare the effect of different exogenous MMP inhibitors on adhesive physical properties of dental adhesives, bond strength, micro permeability and MMP substrate activity. 180-grit Sic paper was used to obtain the superficial dentin surface from each and every tooth af...

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Autores principales:	Pei Zheng, Hui Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6feeec226b1042ee88738a38bbada354
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spelling	oai:doaj.org-article:6feeec226b1042ee88738a38bbada3542021-12-02T15:04:54ZEvaluate the effect of different mmps inhibitors on adhesive physical properties of dental adhesives, bond strength and mmp substarte activity10.1038/s41598-017-04340-12045-2322https://doaj.org/article/6feeec226b1042ee88738a38bbada3542017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04340-1https://doaj.org/toc/2045-2322Abstract We have evaluated and compare the effect of different exogenous MMP inhibitors on adhesive physical properties of dental adhesives, bond strength, micro permeability and MMP substrate activity. 180-grit Sic paper was used to obtain the superficial dentin surface from each and every tooth after the wet grinding procedure. Dentin was exposed to four different MMP inhibitors to evaluate the effect on resin adhesive dentin interface. The four groups used in study were: 2% chlorhexidine digluconate, 2% doxycycline solution, 5% Proanthocyanidin (PR), Control Group. We evaluated and compared the four groups at each and every step of etching, bonding and resin application. Then, the immunolabeling was done with the help of the secondary antibodies with the pH of 7 and the dilution of 1:20. Amongst all the etching pretreatment groups, CHE group (Chlorhexidine etching group) revealed highest exposure to collagen fibrils than the other groups of etching. Then after the CHE group, the next group which has the second highest exposure DOE group. MMP inhibitor application for time duration of 1 minute after the etching procedures significantly improves the bond strength, exposure to collagen fibres and uniforms the dense form of dentin hybrid layer.Pei ZhengHui ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pei Zheng Hui Chen Evaluate the effect of different mmps inhibitors on adhesive physical properties of dental adhesives, bond strength and mmp substarte activity
description	Abstract We have evaluated and compare the effect of different exogenous MMP inhibitors on adhesive physical properties of dental adhesives, bond strength, micro permeability and MMP substrate activity. 180-grit Sic paper was used to obtain the superficial dentin surface from each and every tooth after the wet grinding procedure. Dentin was exposed to four different MMP inhibitors to evaluate the effect on resin adhesive dentin interface. The four groups used in study were: 2% chlorhexidine digluconate, 2% doxycycline solution, 5% Proanthocyanidin (PR), Control Group. We evaluated and compared the four groups at each and every step of etching, bonding and resin application. Then, the immunolabeling was done with the help of the secondary antibodies with the pH of 7 and the dilution of 1:20. Amongst all the etching pretreatment groups, CHE group (Chlorhexidine etching group) revealed highest exposure to collagen fibrils than the other groups of etching. Then after the CHE group, the next group which has the second highest exposure DOE group. MMP inhibitor application for time duration of 1 minute after the etching procedures significantly improves the bond strength, exposure to collagen fibres and uniforms the dense form of dentin hybrid layer.
format	article
author	Pei Zheng Hui Chen
author_facet	Pei Zheng Hui Chen
author_sort	Pei Zheng
title	Evaluate the effect of different mmps inhibitors on adhesive physical properties of dental adhesives, bond strength and mmp substarte activity
title_short	Evaluate the effect of different mmps inhibitors on adhesive physical properties of dental adhesives, bond strength and mmp substarte activity
title_full	Evaluate the effect of different mmps inhibitors on adhesive physical properties of dental adhesives, bond strength and mmp substarte activity
title_fullStr	Evaluate the effect of different mmps inhibitors on adhesive physical properties of dental adhesives, bond strength and mmp substarte activity
title_full_unstemmed	Evaluate the effect of different mmps inhibitors on adhesive physical properties of dental adhesives, bond strength and mmp substarte activity
title_sort	evaluate the effect of different mmps inhibitors on adhesive physical properties of dental adhesives, bond strength and mmp substarte activity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6feeec226b1042ee88738a38bbada354
work_keys_str_mv	AT peizheng evaluatetheeffectofdifferentmmpsinhibitorsonadhesivephysicalpropertiesofdentaladhesivesbondstrengthandmmpsubstarteactivity AT huichen evaluatetheeffectofdifferentmmpsinhibitorsonadhesivephysicalpropertiesofdentaladhesivesbondstrengthandmmpsubstarteactivity
_version_	1718389023772246016

Evaluate the effect of different mmps inhibitors on adhesive physical properties of dental adhesives, bond strength and mmp substarte activity

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