Direct evidence that scorpion α-toxins (site-3) modulate sodium channel inactivation by hindrance of voltage-sensor movements.
The position of the voltage-sensing transmembrane segment, S4, in voltage-gated ion channels as a function of voltage remains incompletely elucidated. Site-3 toxins bind primarily to the extracellular loops connecting transmembrane helical segments S1-S2 and S3-S4 in Domain 4 (D4) and S5-S6 in Domai...
Guardado en:
Autores principales: | Zhongming Ma, Jun Kong, Dalia Gordon, Michael Gurevitz, Roland G Kallen |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2013
|
Materias: | |
Acceso en línea: | https://doaj.org/article/6ff0ae15281c45bcacfd8359c0720ee3 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin
por: Daohua Jiang, et al.
Publicado: (2021) -
The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity
por: Joshua S. Wingerd, et al.
Publicado: (2017) -
Voltage-gated sodium channels assemble and gate as dimers
por: Jérôme Clatot, et al.
Publicado: (2017) -
Nav channel binder containing a specific conjugation-site based on a low toxicity β-scorpion toxin
por: Tomoya Kubota, et al.
Publicado: (2017) -
Global transcriptome analysis of the scorpion Centruroides noxius: new toxin families and evolutionary insights from an ancestral scorpion species.
por: Martha Rendón-Anaya, et al.
Publicado: (2012)