Augmenting regional and targeted delivery in the pulmonary acinus using magnetic particles

Yan Ostrovski, Philipp Hofemeier, Josué Sznitman Department of Biomedical Engineering, Technion – Israel Institute of Technology, Haifa, Israel Background: It has been hypothesized that by coupling magnetic particles to inhaled therapeutics, the ability to target specific lung r...

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Autores principales:	Ostrovski Y, Hofemeier P, Sznitman J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	inhalation medicine regional pulmonary delivery targeted delivery magnetic particles CFD Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6ff54d89a6f24f9cba2e7b930bfdf1b7
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spelling	oai:doaj.org-article:6ff54d89a6f24f9cba2e7b930bfdf1b72021-12-02T02:01:42ZAugmenting regional and targeted delivery in the pulmonary acinus using magnetic particles1178-2013https://doaj.org/article/6ff54d89a6f24f9cba2e7b930bfdf1b72016-07-01T00:00:00Zhttps://www.dovepress.com/augmenting-regional-and-targeted-delivery-in-the-pulmonary-acinus-usin-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yan Ostrovski, Philipp Hofemeier, Josué Sznitman Department of Biomedical Engineering, Technion – Israel Institute of Technology, Haifa, Israel Background: It has been hypothesized that by coupling magnetic particles to inhaled therapeutics, the ability to target specific lung regions (eg, only acinar deposition), or even more so specific points in the lung (eg, tumor targeting), can be substantially improved. Although this method has been proven feasible in seminal in vivo studies, there is still a wide gap in our basic understanding of the transport phenomena of magnetic particles in the pulmonary acinar regions of the lungs, including particle dynamics and deposition characteristics.Methods: Here, we present computational fluid dynamics-discrete element method simulations of magnetically loaded microdroplet carriers in an anatomically inspired, space-filling, multi-generation acinar airway tree. Breathing motion is modeled by kinematic sinusoidal displacements of the acinar walls, during which droplets are inhaled and exhaled. Particle dynamics are governed by viscous drag, gravity, and Brownian motion as well as the external magnetic force. In particular, we examined the roles of droplet diameter and volume fraction of magnetic material within the droplets under two different breathing maneuvers.Results and discussion: Our results indicate that by using magnetic-loaded droplets, 100% of the particles that enter are deposited in the acinar region. This is consistent across all particle sizes investigated (ie, 0.5–3.0 µm). This is best achieved through a deep inhalation maneuver combined with a breath-hold. Particles are found to penetrate deep into the acinus and disperse well, while the required amount of magnetic material is maintained low (<2.5%). Although particles in the size range of ~90–500 nm typically show the lowest deposition fractions, our results suggest that this feature could be leveraged to augment targeted delivery. Keywords: inhalation medicine, targeted delivery, SPIONs, aerosol, CFDOstrovski YHofemeier PSznitman JDove Medical Pressarticleinhalation medicineregional pulmonary deliverytargeted deliverymagnetic particlesCFDMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 3385-3395 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	inhalation medicine regional pulmonary delivery targeted delivery magnetic particles CFD Medicine (General) R5-920
spellingShingle	inhalation medicine regional pulmonary delivery targeted delivery magnetic particles CFD Medicine (General) R5-920 Ostrovski Y Hofemeier P Sznitman J Augmenting regional and targeted delivery in the pulmonary acinus using magnetic particles
description	Yan Ostrovski, Philipp Hofemeier, Josué Sznitman Department of Biomedical Engineering, Technion – Israel Institute of Technology, Haifa, Israel Background: It has been hypothesized that by coupling magnetic particles to inhaled therapeutics, the ability to target specific lung regions (eg, only acinar deposition), or even more so specific points in the lung (eg, tumor targeting), can be substantially improved. Although this method has been proven feasible in seminal in vivo studies, there is still a wide gap in our basic understanding of the transport phenomena of magnetic particles in the pulmonary acinar regions of the lungs, including particle dynamics and deposition characteristics.Methods: Here, we present computational fluid dynamics-discrete element method simulations of magnetically loaded microdroplet carriers in an anatomically inspired, space-filling, multi-generation acinar airway tree. Breathing motion is modeled by kinematic sinusoidal displacements of the acinar walls, during which droplets are inhaled and exhaled. Particle dynamics are governed by viscous drag, gravity, and Brownian motion as well as the external magnetic force. In particular, we examined the roles of droplet diameter and volume fraction of magnetic material within the droplets under two different breathing maneuvers.Results and discussion: Our results indicate that by using magnetic-loaded droplets, 100% of the particles that enter are deposited in the acinar region. This is consistent across all particle sizes investigated (ie, 0.5–3.0 µm). This is best achieved through a deep inhalation maneuver combined with a breath-hold. Particles are found to penetrate deep into the acinus and disperse well, while the required amount of magnetic material is maintained low (<2.5%). Although particles in the size range of ~90–500 nm typically show the lowest deposition fractions, our results suggest that this feature could be leveraged to augment targeted delivery. Keywords: inhalation medicine, targeted delivery, SPIONs, aerosol, CFD
format	article
author	Ostrovski Y Hofemeier P Sznitman J
author_facet	Ostrovski Y Hofemeier P Sznitman J
author_sort	Ostrovski Y
title	Augmenting regional and targeted delivery in the pulmonary acinus using magnetic particles
title_short	Augmenting regional and targeted delivery in the pulmonary acinus using magnetic particles
title_full	Augmenting regional and targeted delivery in the pulmonary acinus using magnetic particles
title_fullStr	Augmenting regional and targeted delivery in the pulmonary acinus using magnetic particles
title_full_unstemmed	Augmenting regional and targeted delivery in the pulmonary acinus using magnetic particles
title_sort	augmenting regional and targeted delivery in the pulmonary acinus using magnetic particles
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/6ff54d89a6f24f9cba2e7b930bfdf1b7
work_keys_str_mv	AT ostrovskiy augmentingregionalandtargeteddeliveryinthepulmonaryacinususingmagneticparticles AT hofemeierp augmentingregionalandtargeteddeliveryinthepulmonaryacinususingmagneticparticles AT sznitmanj augmentingregionalandtargeteddeliveryinthepulmonaryacinususingmagneticparticles
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Augmenting regional and targeted delivery in the pulmonary acinus using magnetic particles

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