Serum Micro-RNA-122 Level as a Simple Noninvasive Marker of MAFLD Severity

Mona A Hegazy,1 Ibrahim Abd ALgwad,1 Soheir Abuel Fadl,1 Mohamed Sayed Hassan,1 Laila Ahmed Rashed,2 Maha A Hussein1 1Internal Medicine Department, Kasr Al-Aini Hospitals, Cairo University, Cairo, Egypt; 2Biochemistry Department, Kasr Al-Aini Hospitals, Cairo University, Cairo, EgyptCorrespondence:...

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Autores principales:	Hegazy MA, Abd ALgwad I, Abuel Fadl S, Sayed Hassan M, Ahmed Rashed L, Hussein MA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	mafld micro rna steatosis and fibrosis Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/6ff86db902d8408f87f50781016f7d26
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spelling	oai:doaj.org-article:6ff86db902d8408f87f50781016f7d262021-12-02T15:57:49ZSerum Micro-RNA-122 Level as a Simple Noninvasive Marker of MAFLD Severity1178-7007https://doaj.org/article/6ff86db902d8408f87f50781016f7d262021-05-01T00:00:00Zhttps://www.dovepress.com/serum-micro-rna-122-level-as-a-simple-noninvasive-marker-of-mafld-seve-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Mona A Hegazy,1 Ibrahim Abd ALgwad,1 Soheir Abuel Fadl,1 Mohamed Sayed Hassan,1 Laila Ahmed Rashed,2 Maha A Hussein1 1Internal Medicine Department, Kasr Al-Aini Hospitals, Cairo University, Cairo, Egypt; 2Biochemistry Department, Kasr Al-Aini Hospitals, Cairo University, Cairo, EgyptCorrespondence: Mona A HegazyInternal Medicine Department, Kasr Al-Aini Hospitals, Cairo University, Cairo, EgyptEmail monahegazy@cu.edu.egBackground: Metabolic-associated fatty liver disease (MAFLD) is a common disease worldwide. Micro-RNA-122 is known to be the most abundant micro-RNA expressed in the liver.Objective: To evaluate the association of micro-RNA-122 and the degree of steatosis and fibrosis in obese patients with MAFLD.Methods: The study included 120 obese Egyptian patients with MAFLD, which were diagnosed and classified according to ultra-sonographic liver findings. All patients enrolled in the study were subjected to thorough clinical examination and laboratory investigations (serum micro-RNA-122 levels by PCR, lipid profile, liver biochemistry, and functions). Fibro-scan was used to assess the level of fibrosis.Results: There was a significant increase in levels of micro-RNA-122 in obese patients with MAFLD compared to controls (p< 0.001). Micro-RNA-122 level was lower in patients with mild liver steatosis than patients with moderate or severe steatosis (p< 0.001). It was lower in patients with a mild degree of fibrosis than those with mild or moderate fibrosis (p< 0.001). Micro-RNA-122 was significantly positively correlated with low-density cholesterol and triglycerides level, and liver enzymes, and negatively correlated to high-density cholesterol (p< 0.001).Conclusion: Serum micro-RNA-122 could be a useful predictor of assessing MAFLD severity regarding level of steatosis or fibrosis.Keywords: MAFLD, micro RNA, steatosis and fibrosisHegazy MAAbd ALgwad IAbuel Fadl SSayed Hassan MAhmed Rashed LHussein MADove Medical Pressarticlemafldmicro rnasteatosis and fibrosisSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 2247-2254 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mafld micro rna steatosis and fibrosis Specialties of internal medicine RC581-951
spellingShingle	mafld micro rna steatosis and fibrosis Specialties of internal medicine RC581-951 Hegazy MA Abd ALgwad I Abuel Fadl S Sayed Hassan M Ahmed Rashed L Hussein MA Serum Micro-RNA-122 Level as a Simple Noninvasive Marker of MAFLD Severity
description	Mona A Hegazy,1 Ibrahim Abd ALgwad,1 Soheir Abuel Fadl,1 Mohamed Sayed Hassan,1 Laila Ahmed Rashed,2 Maha A Hussein1 1Internal Medicine Department, Kasr Al-Aini Hospitals, Cairo University, Cairo, Egypt; 2Biochemistry Department, Kasr Al-Aini Hospitals, Cairo University, Cairo, EgyptCorrespondence: Mona A HegazyInternal Medicine Department, Kasr Al-Aini Hospitals, Cairo University, Cairo, EgyptEmail monahegazy@cu.edu.egBackground: Metabolic-associated fatty liver disease (MAFLD) is a common disease worldwide. Micro-RNA-122 is known to be the most abundant micro-RNA expressed in the liver.Objective: To evaluate the association of micro-RNA-122 and the degree of steatosis and fibrosis in obese patients with MAFLD.Methods: The study included 120 obese Egyptian patients with MAFLD, which were diagnosed and classified according to ultra-sonographic liver findings. All patients enrolled in the study were subjected to thorough clinical examination and laboratory investigations (serum micro-RNA-122 levels by PCR, lipid profile, liver biochemistry, and functions). Fibro-scan was used to assess the level of fibrosis.Results: There was a significant increase in levels of micro-RNA-122 in obese patients with MAFLD compared to controls (p< 0.001). Micro-RNA-122 level was lower in patients with mild liver steatosis than patients with moderate or severe steatosis (p< 0.001). It was lower in patients with a mild degree of fibrosis than those with mild or moderate fibrosis (p< 0.001). Micro-RNA-122 was significantly positively correlated with low-density cholesterol and triglycerides level, and liver enzymes, and negatively correlated to high-density cholesterol (p< 0.001).Conclusion: Serum micro-RNA-122 could be a useful predictor of assessing MAFLD severity regarding level of steatosis or fibrosis.Keywords: MAFLD, micro RNA, steatosis and fibrosis
format	article
author	Hegazy MA Abd ALgwad I Abuel Fadl S Sayed Hassan M Ahmed Rashed L Hussein MA
author_facet	Hegazy MA Abd ALgwad I Abuel Fadl S Sayed Hassan M Ahmed Rashed L Hussein MA
author_sort	Hegazy MA
title	Serum Micro-RNA-122 Level as a Simple Noninvasive Marker of MAFLD Severity
title_short	Serum Micro-RNA-122 Level as a Simple Noninvasive Marker of MAFLD Severity
title_full	Serum Micro-RNA-122 Level as a Simple Noninvasive Marker of MAFLD Severity
title_fullStr	Serum Micro-RNA-122 Level as a Simple Noninvasive Marker of MAFLD Severity
title_full_unstemmed	Serum Micro-RNA-122 Level as a Simple Noninvasive Marker of MAFLD Severity
title_sort	serum micro-rna-122 level as a simple noninvasive marker of mafld severity
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/6ff86db902d8408f87f50781016f7d26
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Serum Micro-RNA-122 Level as a Simple Noninvasive Marker of MAFLD Severity

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