Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer’s disease

Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer’s disease

Imaging tools for evaluating progression of Alzheimer’s disease have been lacking. Here the authors develop a blood brain barrier-permeable Aß probe based on a radiolabelled, anti-Aß antibody, and report age-dependent brain uptake visualized in vivo with PET in mouse models of the disease.

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Autores principales: Dag Sehlin, Xiaotian T. Fang, Linda Cato, Gunnar Antoni, Lars Lannfelt, Stina Syvänen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/6ff8814765814c6eabc58af15ab9f554
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spelling oai:doaj.org-article:6ff8814765814c6eabc58af15ab9f5542021-12-02T15:34:33ZAntibody-based PET imaging of amyloid beta in mouse models of Alzheimer’s disease10.1038/ncomms107592041-1723https://doaj.org/article/6ff8814765814c6eabc58af15ab9f5542016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10759https://doaj.org/toc/2041-1723Imaging tools for evaluating progression of Alzheimer’s disease have been lacking. Here the authors develop a blood brain barrier-permeable Aß probe based on a radiolabelled, anti-Aß antibody, and report age-dependent brain uptake visualized in vivo with PET in mouse models of the disease.Dag SehlinXiaotian T. FangLinda CatoGunnar AntoniLars LannfeltStina SyvänenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Dag Sehlin
Xiaotian T. Fang
Linda Cato
Gunnar Antoni
Lars Lannfelt
Stina Syvänen
Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer’s disease
description Imaging tools for evaluating progression of Alzheimer’s disease have been lacking. Here the authors develop a blood brain barrier-permeable Aß probe based on a radiolabelled, anti-Aß antibody, and report age-dependent brain uptake visualized in vivo with PET in mouse models of the disease.
format article
author Dag Sehlin
Xiaotian T. Fang
Linda Cato
Gunnar Antoni
Lars Lannfelt
Stina Syvänen
author_facet Dag Sehlin
Xiaotian T. Fang
Linda Cato
Gunnar Antoni
Lars Lannfelt
Stina Syvänen
author_sort Dag Sehlin
title Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer’s disease
title_short Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer’s disease
title_full Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer’s disease
title_fullStr Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer’s disease
title_full_unstemmed Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer’s disease
title_sort antibody-based pet imaging of amyloid beta in mouse models of alzheimer’s disease
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/6ff8814765814c6eabc58af15ab9f554
work_keys_str_mv AT dagsehlin antibodybasedpetimagingofamyloidbetainmousemodelsofalzheimersdisease
AT xiaotiantfang antibodybasedpetimagingofamyloidbetainmousemodelsofalzheimersdisease
AT lindacato antibodybasedpetimagingofamyloidbetainmousemodelsofalzheimersdisease
AT gunnarantoni antibodybasedpetimagingofamyloidbetainmousemodelsofalzheimersdisease
AT larslannfelt antibodybasedpetimagingofamyloidbetainmousemodelsofalzheimersdisease
AT stinasyvanen antibodybasedpetimagingofamyloidbetainmousemodelsofalzheimersdisease
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