Diagnosis of Peanut Allergy in Preschool Children: The Impact of Skin Testing With a Novel Composition of Peanuts
Peanut allergy is an increasing concern in younger children. Available bedside diagnostic tools, i.e., prick tests with commercial extracts or peanut-containing foods have only limited predictive values. In a cohort of preschoolers with both a history of allergic reactions and sensitization to peanu...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:6ffaeca5d5074193b22d30debb66aef92021-12-01T20:38:04ZDiagnosis of Peanut Allergy in Preschool Children: The Impact of Skin Testing With a Novel Composition of Peanuts2296-236010.3389/fped.2021.739224https://doaj.org/article/6ffaeca5d5074193b22d30debb66aef92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fped.2021.739224/fullhttps://doaj.org/toc/2296-2360Peanut allergy is an increasing concern in younger children. Available bedside diagnostic tools, i.e., prick tests with commercial extracts or peanut-containing foods have only limited predictive values. In a cohort of preschoolers with both a history of allergic reactions and sensitization to peanut proteins, we aimed to characterize the impact of skin tests with a novel composition of peanuts LPP-MH. Almost one quarter (27/110) of preschool children, with a history of allergic reactions to peanuts and positive standard IgE-mediated tests for peanut allergy, can tolerate the reintroduction of peanut proteins into their diet after resolving their allergy and, thus, can avoid adverse health outcomes associated with the false diagnosis. In the younger age group, a quarter of peanut allergic children, display a relatively high threshold, potentially enabling an easier and safer oral immunotherapy protocol in this window of opportunity in childhood. The use of the novel diagnostic skin test, LPP-MH, significantly improves the predictive value of outpatient evaluation for the outcomes of peanut challenge as well as the expected threshold at which the PA child will react, thus, making for a better informed decision of how, when, and where to challenge.Mona I. KidonMona I. KidonMona I. KidonSoad Haj YahiaSoad Haj YahiaDiti Machnes-MaayanDiti Machnes-MaayanDiti Machnes-MaayanYael LevyShirli FrizinskyShirli FrizinskyShirli FrizinskyRamit Maoz-SegalIrena OffengandenRon S. KenettNancy Agmon-LevinNancy Agmon-LevinNancy Agmon-LevinRan HovavFrontiers Media S.A.articlepeanutallergydiagnosisearly lifepreschoolhigh thresholdPediatricsRJ1-570ENFrontiers in Pediatrics, Vol 9 (2021) |
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| collection |
DOAJ |
| language |
EN |
| topic |
peanut allergy diagnosis early life preschool high threshold Pediatrics RJ1-570 |
| spellingShingle |
peanut allergy diagnosis early life preschool high threshold Pediatrics RJ1-570 Mona I. Kidon Mona I. Kidon Mona I. Kidon Soad Haj Yahia Soad Haj Yahia Diti Machnes-Maayan Diti Machnes-Maayan Diti Machnes-Maayan Yael Levy Shirli Frizinsky Shirli Frizinsky Shirli Frizinsky Ramit Maoz-Segal Irena Offenganden Ron S. Kenett Nancy Agmon-Levin Nancy Agmon-Levin Nancy Agmon-Levin Ran Hovav Diagnosis of Peanut Allergy in Preschool Children: The Impact of Skin Testing With a Novel Composition of Peanuts |
| description |
Peanut allergy is an increasing concern in younger children. Available bedside diagnostic tools, i.e., prick tests with commercial extracts or peanut-containing foods have only limited predictive values. In a cohort of preschoolers with both a history of allergic reactions and sensitization to peanut proteins, we aimed to characterize the impact of skin tests with a novel composition of peanuts LPP-MH. Almost one quarter (27/110) of preschool children, with a history of allergic reactions to peanuts and positive standard IgE-mediated tests for peanut allergy, can tolerate the reintroduction of peanut proteins into their diet after resolving their allergy and, thus, can avoid adverse health outcomes associated with the false diagnosis. In the younger age group, a quarter of peanut allergic children, display a relatively high threshold, potentially enabling an easier and safer oral immunotherapy protocol in this window of opportunity in childhood. The use of the novel diagnostic skin test, LPP-MH, significantly improves the predictive value of outpatient evaluation for the outcomes of peanut challenge as well as the expected threshold at which the PA child will react, thus, making for a better informed decision of how, when, and where to challenge. |
| format |
article |
| author |
Mona I. Kidon Mona I. Kidon Mona I. Kidon Soad Haj Yahia Soad Haj Yahia Diti Machnes-Maayan Diti Machnes-Maayan Diti Machnes-Maayan Yael Levy Shirli Frizinsky Shirli Frizinsky Shirli Frizinsky Ramit Maoz-Segal Irena Offenganden Ron S. Kenett Nancy Agmon-Levin Nancy Agmon-Levin Nancy Agmon-Levin Ran Hovav |
| author_facet |
Mona I. Kidon Mona I. Kidon Mona I. Kidon Soad Haj Yahia Soad Haj Yahia Diti Machnes-Maayan Diti Machnes-Maayan Diti Machnes-Maayan Yael Levy Shirli Frizinsky Shirli Frizinsky Shirli Frizinsky Ramit Maoz-Segal Irena Offenganden Ron S. Kenett Nancy Agmon-Levin Nancy Agmon-Levin Nancy Agmon-Levin Ran Hovav |
| author_sort |
Mona I. Kidon |
| title |
Diagnosis of Peanut Allergy in Preschool Children: The Impact of Skin Testing With a Novel Composition of Peanuts |
| title_short |
Diagnosis of Peanut Allergy in Preschool Children: The Impact of Skin Testing With a Novel Composition of Peanuts |
| title_full |
Diagnosis of Peanut Allergy in Preschool Children: The Impact of Skin Testing With a Novel Composition of Peanuts |
| title_fullStr |
Diagnosis of Peanut Allergy in Preschool Children: The Impact of Skin Testing With a Novel Composition of Peanuts |
| title_full_unstemmed |
Diagnosis of Peanut Allergy in Preschool Children: The Impact of Skin Testing With a Novel Composition of Peanuts |
| title_sort |
diagnosis of peanut allergy in preschool children: the impact of skin testing with a novel composition of peanuts |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/6ffaeca5d5074193b22d30debb66aef9 |
| work_keys_str_mv |
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