DNMT3B isoforms without catalytic activity stimulate gene body methylation as accessory proteins in somatic cells

De novoDNA methylation is carried out by DNA methyltransferase DNMT3A/B, although DNMT3B isoforms without active catalytic domains are widely expressed. Here, the authors show that DNMT3B isoforms stimulate gene body methylation and re-methylation independently of the isoforms' catalytic activi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Christopher E. Duymich, Jessica Charlet, Xiaojing Yang, Peter A. Jones, Gangning Liang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6fff695162a545e784e208e5e545cf7e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6fff695162a545e784e208e5e545cf7e
record_format	dspace
spelling	oai:doaj.org-article:6fff695162a545e784e208e5e545cf7e2021-12-02T14:38:55ZDNMT3B isoforms without catalytic activity stimulate gene body methylation as accessory proteins in somatic cells10.1038/ncomms114532041-1723https://doaj.org/article/6fff695162a545e784e208e5e545cf7e2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11453https://doaj.org/toc/2041-1723De novoDNA methylation is carried out by DNA methyltransferase DNMT3A/B, although DNMT3B isoforms without active catalytic domains are widely expressed. Here, the authors show that DNMT3B isoforms stimulate gene body methylation and re-methylation independently of the isoforms' catalytic activity.Christopher E. DuymichJessica CharletXiaojing YangPeter A. JonesGangning LiangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christopher E. Duymich Jessica Charlet Xiaojing Yang Peter A. Jones Gangning Liang DNMT3B isoforms without catalytic activity stimulate gene body methylation as accessory proteins in somatic cells
description	De novoDNA methylation is carried out by DNA methyltransferase DNMT3A/B, although DNMT3B isoforms without active catalytic domains are widely expressed. Here, the authors show that DNMT3B isoforms stimulate gene body methylation and re-methylation independently of the isoforms' catalytic activity.
format	article
author	Christopher E. Duymich Jessica Charlet Xiaojing Yang Peter A. Jones Gangning Liang
author_facet	Christopher E. Duymich Jessica Charlet Xiaojing Yang Peter A. Jones Gangning Liang
author_sort	Christopher E. Duymich
title	DNMT3B isoforms without catalytic activity stimulate gene body methylation as accessory proteins in somatic cells
title_short	DNMT3B isoforms without catalytic activity stimulate gene body methylation as accessory proteins in somatic cells
title_full	DNMT3B isoforms without catalytic activity stimulate gene body methylation as accessory proteins in somatic cells
title_fullStr	DNMT3B isoforms without catalytic activity stimulate gene body methylation as accessory proteins in somatic cells
title_full_unstemmed	DNMT3B isoforms without catalytic activity stimulate gene body methylation as accessory proteins in somatic cells
title_sort	dnmt3b isoforms without catalytic activity stimulate gene body methylation as accessory proteins in somatic cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6fff695162a545e784e208e5e545cf7e
work_keys_str_mv	AT christophereduymich dnmt3bisoformswithoutcatalyticactivitystimulategenebodymethylationasaccessoryproteinsinsomaticcells AT jessicacharlet dnmt3bisoformswithoutcatalyticactivitystimulategenebodymethylationasaccessoryproteinsinsomaticcells AT xiaojingyang dnmt3bisoformswithoutcatalyticactivitystimulategenebodymethylationasaccessoryproteinsinsomaticcells AT peterajones dnmt3bisoformswithoutcatalyticactivitystimulategenebodymethylationasaccessoryproteinsinsomaticcells AT gangningliang dnmt3bisoformswithoutcatalyticactivitystimulategenebodymethylationasaccessoryproteinsinsomaticcells
_version_	1718390841040437248

DNMT3B isoforms without catalytic activity stimulate gene body methylation as accessory proteins in somatic cells

Ejemplares similares