Tumor-associated macrophages (TAMs) as biomarkers for gastric cancer: A review

Gastric adenocarcinoma is one of the most common types of cancer worldwide, with an incidence of a million new cases annually. In addition to having a high mortality rate due to often delayed detection and its poor response to cancer therapy, it also spreads aggressively. Inflammation has been shown...

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Autores principales:	Meri R. Räihä, Pauli A. Puolakkainen
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2018
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/700687f9a6ee437cab2ccb569d548d31
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spelling	oai:doaj.org-article:700687f9a6ee437cab2ccb569d548d312021-12-02T15:50:54ZTumor-associated macrophages (TAMs) as biomarkers for gastric cancer: A review2095-882X10.1016/j.cdtm.2018.07.001https://doaj.org/article/700687f9a6ee437cab2ccb569d548d312018-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X18300112https://doaj.org/toc/2095-882XGastric adenocarcinoma is one of the most common types of cancer worldwide, with an incidence of a million new cases annually. In addition to having a high mortality rate due to often delayed detection and its poor response to cancer therapy, it also spreads aggressively. Inflammation has been shown to play a role in carcinogenesis. Consequently, macrophages are important in phagocytosis, antigen presenting and producing cytokines and growth factors. As a response to microenvironmental signals, they may polarize into tumor resisting M1 or tumor promoting M2 macrophages. Recently, studies have indicated that M2-type macrophage resembling tumor-associated macrophages (TAMs) might be used as an independent prognostic factor for gastric cancer. This review will discuss the possible use of TAMs as prognostic tools for gastric cancer and whether they are suitable for use in clinical environment. Keywords: Gastric cancer, Tumor-associated macrophages, Biomarkers, Prognosis, DiagnosisMeri R. RäihäPauli A. PuolakkainenKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 4, Iss 3, Pp 156-163 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Meri R. Räihä Pauli A. Puolakkainen Tumor-associated macrophages (TAMs) as biomarkers for gastric cancer: A review
description	Gastric adenocarcinoma is one of the most common types of cancer worldwide, with an incidence of a million new cases annually. In addition to having a high mortality rate due to often delayed detection and its poor response to cancer therapy, it also spreads aggressively. Inflammation has been shown to play a role in carcinogenesis. Consequently, macrophages are important in phagocytosis, antigen presenting and producing cytokines and growth factors. As a response to microenvironmental signals, they may polarize into tumor resisting M1 or tumor promoting M2 macrophages. Recently, studies have indicated that M2-type macrophage resembling tumor-associated macrophages (TAMs) might be used as an independent prognostic factor for gastric cancer. This review will discuss the possible use of TAMs as prognostic tools for gastric cancer and whether they are suitable for use in clinical environment. Keywords: Gastric cancer, Tumor-associated macrophages, Biomarkers, Prognosis, Diagnosis
format	article
author	Meri R. Räihä Pauli A. Puolakkainen
author_facet	Meri R. Räihä Pauli A. Puolakkainen
author_sort	Meri R. Räihä
title	Tumor-associated macrophages (TAMs) as biomarkers for gastric cancer: A review
title_short	Tumor-associated macrophages (TAMs) as biomarkers for gastric cancer: A review
title_full	Tumor-associated macrophages (TAMs) as biomarkers for gastric cancer: A review
title_fullStr	Tumor-associated macrophages (TAMs) as biomarkers for gastric cancer: A review
title_full_unstemmed	Tumor-associated macrophages (TAMs) as biomarkers for gastric cancer: A review
title_sort	tumor-associated macrophages (tams) as biomarkers for gastric cancer: a review
publisher	KeAi Communications Co., Ltd.
publishDate	2018
url	https://doaj.org/article/700687f9a6ee437cab2ccb569d548d31
work_keys_str_mv	AT merirraiha tumorassociatedmacrophagestamsasbiomarkersforgastriccancerareview AT pauliapuolakkainen tumorassociatedmacrophagestamsasbiomarkersforgastriccancerareview
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Tumor-associated macrophages (TAMs) as biomarkers for gastric cancer: A review

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