Tumor-associated macrophages (TAMs) as biomarkers for gastric cancer: A review

Gastric adenocarcinoma is one of the most common types of cancer worldwide, with an incidence of a million new cases annually. In addition to having a high mortality rate due to often delayed detection and its poor response to cancer therapy, it also spreads aggressively. Inflammation has been shown...

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Autores principales: Meri R. Räihä, Pauli A. Puolakkainen
Formato: article
Lenguaje:EN
Publicado: KeAi Communications Co., Ltd. 2018
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Acceso en línea:https://doaj.org/article/700687f9a6ee437cab2ccb569d548d31
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spelling oai:doaj.org-article:700687f9a6ee437cab2ccb569d548d312021-12-02T15:50:54ZTumor-associated macrophages (TAMs) as biomarkers for gastric cancer: A review2095-882X10.1016/j.cdtm.2018.07.001https://doaj.org/article/700687f9a6ee437cab2ccb569d548d312018-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X18300112https://doaj.org/toc/2095-882XGastric adenocarcinoma is one of the most common types of cancer worldwide, with an incidence of a million new cases annually. In addition to having a high mortality rate due to often delayed detection and its poor response to cancer therapy, it also spreads aggressively. Inflammation has been shown to play a role in carcinogenesis. Consequently, macrophages are important in phagocytosis, antigen presenting and producing cytokines and growth factors. As a response to microenvironmental signals, they may polarize into tumor resisting M1 or tumor promoting M2 macrophages. Recently, studies have indicated that M2-type macrophage resembling tumor-associated macrophages (TAMs) might be used as an independent prognostic factor for gastric cancer. This review will discuss the possible use of TAMs as prognostic tools for gastric cancer and whether they are suitable for use in clinical environment. Keywords: Gastric cancer, Tumor-associated macrophages, Biomarkers, Prognosis, DiagnosisMeri R. RäihäPauli A. PuolakkainenKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 4, Iss 3, Pp 156-163 (2018)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Meri R. Räihä
Pauli A. Puolakkainen
Tumor-associated macrophages (TAMs) as biomarkers for gastric cancer: A review
description Gastric adenocarcinoma is one of the most common types of cancer worldwide, with an incidence of a million new cases annually. In addition to having a high mortality rate due to often delayed detection and its poor response to cancer therapy, it also spreads aggressively. Inflammation has been shown to play a role in carcinogenesis. Consequently, macrophages are important in phagocytosis, antigen presenting and producing cytokines and growth factors. As a response to microenvironmental signals, they may polarize into tumor resisting M1 or tumor promoting M2 macrophages. Recently, studies have indicated that M2-type macrophage resembling tumor-associated macrophages (TAMs) might be used as an independent prognostic factor for gastric cancer. This review will discuss the possible use of TAMs as prognostic tools for gastric cancer and whether they are suitable for use in clinical environment. Keywords: Gastric cancer, Tumor-associated macrophages, Biomarkers, Prognosis, Diagnosis
format article
author Meri R. Räihä
Pauli A. Puolakkainen
author_facet Meri R. Räihä
Pauli A. Puolakkainen
author_sort Meri R. Räihä
title Tumor-associated macrophages (TAMs) as biomarkers for gastric cancer: A review
title_short Tumor-associated macrophages (TAMs) as biomarkers for gastric cancer: A review
title_full Tumor-associated macrophages (TAMs) as biomarkers for gastric cancer: A review
title_fullStr Tumor-associated macrophages (TAMs) as biomarkers for gastric cancer: A review
title_full_unstemmed Tumor-associated macrophages (TAMs) as biomarkers for gastric cancer: A review
title_sort tumor-associated macrophages (tams) as biomarkers for gastric cancer: a review
publisher KeAi Communications Co., Ltd.
publishDate 2018
url https://doaj.org/article/700687f9a6ee437cab2ccb569d548d31
work_keys_str_mv AT merirraiha tumorassociatedmacrophagestamsasbiomarkersforgastriccancerareview
AT pauliapuolakkainen tumorassociatedmacrophagestamsasbiomarkersforgastriccancerareview
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