Insulin Topical Application for Wound Healing in Nondiabetic Patients

Background. Low-cost and safe strategies to improve wound healing will be of great social and economic value. The goal of this pilot clinical trial is aimed at analyzing how effective insulin therapy is at healing wounds in nondiabetic people. Methods. In this protocol research, 346 individuals were...

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Autores principales:	Shudong Sun, Lei Zhang, Jun Liu, Huiling Li
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Computer applications to medicine. Medical informatics R858-859.7
Acceso en línea:	https://doaj.org/article/7008f7de6bf14078b26d458d8292b149
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spelling	oai:doaj.org-article:7008f7de6bf14078b26d458d8292b1492021-11-29T00:55:32ZInsulin Topical Application for Wound Healing in Nondiabetic Patients1748-671810.1155/2021/9785466https://doaj.org/article/7008f7de6bf14078b26d458d8292b1492021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/9785466https://doaj.org/toc/1748-6718Background. Low-cost and safe strategies to improve wound healing will be of great social and economic value. The goal of this pilot clinical trial is aimed at analyzing how effective insulin therapy is at healing wounds in nondiabetic people. Methods. In this protocol research, 346 individuals were included. Patients were divided as 2 groups at random: experimental patients were given a ten-unit answer. For each 10 cm2 of wound, insulin was injected in solution with 1 mL 0.9 percent saline, whereas the control group got a standard dressing with normal saline. Results. During the therapy period, no adverse effects were reported. After insulin therapy, no substantial insulin-related side effects were reduced. After 10 days of therapy, the experimental group’s granulation tissue coverage rate and thickness were considerably improved as compared to control. Furthermore, a momentous difference in the occurrence of wound bleeding and suppurative wounds between the two groups (P=0.05). Conclusion. The results of this pilot research suggest that insulin injections could harmless and effective alternative therapy for wound healing in nondiabetic individuals and that larger, placebo-controlled trials are needed to evaluate effectiveness and safety of insulin treatment in wound healing patients.Shudong SunLei ZhangJun LiuHuiling LiHindawi LimitedarticleComputer applications to medicine. Medical informaticsR858-859.7ENComputational and Mathematical Methods in Medicine, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Computer applications to medicine. Medical informatics R858-859.7
spellingShingle	Computer applications to medicine. Medical informatics R858-859.7 Shudong Sun Lei Zhang Jun Liu Huiling Li Insulin Topical Application for Wound Healing in Nondiabetic Patients
description	Background. Low-cost and safe strategies to improve wound healing will be of great social and economic value. The goal of this pilot clinical trial is aimed at analyzing how effective insulin therapy is at healing wounds in nondiabetic people. Methods. In this protocol research, 346 individuals were included. Patients were divided as 2 groups at random: experimental patients were given a ten-unit answer. For each 10 cm2 of wound, insulin was injected in solution with 1 mL 0.9 percent saline, whereas the control group got a standard dressing with normal saline. Results. During the therapy period, no adverse effects were reported. After insulin therapy, no substantial insulin-related side effects were reduced. After 10 days of therapy, the experimental group’s granulation tissue coverage rate and thickness were considerably improved as compared to control. Furthermore, a momentous difference in the occurrence of wound bleeding and suppurative wounds between the two groups (P=0.05). Conclusion. The results of this pilot research suggest that insulin injections could harmless and effective alternative therapy for wound healing in nondiabetic individuals and that larger, placebo-controlled trials are needed to evaluate effectiveness and safety of insulin treatment in wound healing patients.
format	article
author	Shudong Sun Lei Zhang Jun Liu Huiling Li
author_facet	Shudong Sun Lei Zhang Jun Liu Huiling Li
author_sort	Shudong Sun
title	Insulin Topical Application for Wound Healing in Nondiabetic Patients
title_short	Insulin Topical Application for Wound Healing in Nondiabetic Patients
title_full	Insulin Topical Application for Wound Healing in Nondiabetic Patients
title_fullStr	Insulin Topical Application for Wound Healing in Nondiabetic Patients
title_full_unstemmed	Insulin Topical Application for Wound Healing in Nondiabetic Patients
title_sort	insulin topical application for wound healing in nondiabetic patients
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/7008f7de6bf14078b26d458d8292b149
work_keys_str_mv	AT shudongsun insulintopicalapplicationforwoundhealinginnondiabeticpatients AT leizhang insulintopicalapplicationforwoundhealinginnondiabeticpatients AT junliu insulintopicalapplicationforwoundhealinginnondiabeticpatients AT huilingli insulintopicalapplicationforwoundhealinginnondiabeticpatients
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Insulin Topical Application for Wound Healing in Nondiabetic Patients

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