Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome

Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome

Clinical oncology is rapidly adopting next-generation sequencing technology for nucleotide variant and indel detection. Here the authors present a three-platform approach (whole-genome, whole-exome, and whole-transcriptome) in pediatric patients for the detection of diverse types of germline and som...

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Autores principales: Michael Rusch, Joy Nakitandwe, Sheila Shurtleff, Scott Newman, Zhaojie Zhang, Michael N. Edmonson, Matthew Parker, Yuannian Jiao, Xiaotu Ma, Yanling Liu, Jiali Gu, Michael F. Walsh, Jared Becksfort, Andrew Thrasher, Yongjin Li, James McMurry, Erin Hedlund, Aman Patel, John Easton, Donald Yergeau, Bhavin Vadodaria, Ruth G. Tatevossian, Susana Raimondi, Dale Hedges, Xiang Chen, Kohei Hagiwara, Rose McGee, Giles W. Robinson, Jeffery M. Klco, Tanja A. Gruber, David W. Ellison, James R Downing, Jinghui Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/70098f25f1d6428b99342a75e0d3ce05
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spelling oai:doaj.org-article:70098f25f1d6428b99342a75e0d3ce052021-12-02T16:50:11ZClinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome10.1038/s41467-018-06485-72041-1723https://doaj.org/article/70098f25f1d6428b99342a75e0d3ce052018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06485-7https://doaj.org/toc/2041-1723Clinical oncology is rapidly adopting next-generation sequencing technology for nucleotide variant and indel detection. Here the authors present a three-platform approach (whole-genome, whole-exome, and whole-transcriptome) in pediatric patients for the detection of diverse types of germline and somatic variants.Michael RuschJoy NakitandweSheila ShurtleffScott NewmanZhaojie ZhangMichael N. EdmonsonMatthew ParkerYuannian JiaoXiaotu MaYanling LiuJiali GuMichael F. WalshJared BecksfortAndrew ThrasherYongjin LiJames McMurryErin HedlundAman PatelJohn EastonDonald YergeauBhavin VadodariaRuth G. TatevossianSusana RaimondiDale HedgesXiang ChenKohei HagiwaraRose McGeeGiles W. RobinsonJeffery M. KlcoTanja A. GruberDavid W. EllisonJames R DowningJinghui ZhangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Michael Rusch
Joy Nakitandwe
Sheila Shurtleff
Scott Newman
Zhaojie Zhang
Michael N. Edmonson
Matthew Parker
Yuannian Jiao
Xiaotu Ma
Yanling Liu
Jiali Gu
Michael F. Walsh
Jared Becksfort
Andrew Thrasher
Yongjin Li
James McMurry
Erin Hedlund
Aman Patel
John Easton
Donald Yergeau
Bhavin Vadodaria
Ruth G. Tatevossian
Susana Raimondi
Dale Hedges
Xiang Chen
Kohei Hagiwara
Rose McGee
Giles W. Robinson
Jeffery M. Klco
Tanja A. Gruber
David W. Ellison
James R Downing
Jinghui Zhang
Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome
description Clinical oncology is rapidly adopting next-generation sequencing technology for nucleotide variant and indel detection. Here the authors present a three-platform approach (whole-genome, whole-exome, and whole-transcriptome) in pediatric patients for the detection of diverse types of germline and somatic variants.
format article
author Michael Rusch
Joy Nakitandwe
Sheila Shurtleff
Scott Newman
Zhaojie Zhang
Michael N. Edmonson
Matthew Parker
Yuannian Jiao
Xiaotu Ma
Yanling Liu
Jiali Gu
Michael F. Walsh
Jared Becksfort
Andrew Thrasher
Yongjin Li
James McMurry
Erin Hedlund
Aman Patel
John Easton
Donald Yergeau
Bhavin Vadodaria
Ruth G. Tatevossian
Susana Raimondi
Dale Hedges
Xiang Chen
Kohei Hagiwara
Rose McGee
Giles W. Robinson
Jeffery M. Klco
Tanja A. Gruber
David W. Ellison
James R Downing
Jinghui Zhang
author_facet Michael Rusch
Joy Nakitandwe
Sheila Shurtleff
Scott Newman
Zhaojie Zhang
Michael N. Edmonson
Matthew Parker
Yuannian Jiao
Xiaotu Ma
Yanling Liu
Jiali Gu
Michael F. Walsh
Jared Becksfort
Andrew Thrasher
Yongjin Li
James McMurry
Erin Hedlund
Aman Patel
John Easton
Donald Yergeau
Bhavin Vadodaria
Ruth G. Tatevossian
Susana Raimondi
Dale Hedges
Xiang Chen
Kohei Hagiwara
Rose McGee
Giles W. Robinson
Jeffery M. Klco
Tanja A. Gruber
David W. Ellison
James R Downing
Jinghui Zhang
author_sort Michael Rusch
title Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome
title_short Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome
title_full Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome
title_fullStr Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome
title_full_unstemmed Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome
title_sort clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/70098f25f1d6428b99342a75e0d3ce05
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