Association of Allele 61888G>T Polymorphism VDR Gene and Colorectal Cancer

BACKGROUND AND OBJECTIVE: Colorectal cancer is the third most common cancer in the world and it is the fourth most common cancer that is a leading cause of cancer deaths. Polymorphisms of the vitamin D receptor (VDR) gene may influence colorectal cancer risk. The vitamin D receptor (VDR) is a crucia...

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Autores principales:	M Haghighi, SR Mohebbi, MA Pour Hoseingholi, MY Taleghani, SR Fatemi, MR Zali
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2010
Materias:	colorectal cancer vitamin d receptor 61888g>t Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/700e8d6512ae45fc9dd7a1bdb910be7d
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spelling	oai:doaj.org-article:700e8d6512ae45fc9dd7a1bdb910be7d2021-11-10T09:00:14ZAssociation of Allele 61888G>T Polymorphism VDR Gene and Colorectal Cancer1561-41072251-7170https://doaj.org/article/700e8d6512ae45fc9dd7a1bdb910be7d2010-04-01T00:00:00Zhttp://jbums.org/article-1-3408-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Colorectal cancer is the third most common cancer in the world and it is the fourth most common cancer that is a leading cause of cancer deaths. Polymorphisms of the vitamin D receptor (VDR) gene may influence colorectal cancer risk. The vitamin D receptor (VDR) is a crucial mediator for the cellular effects of vitamin D and additionally interacts with other cell-signaling pathways that influence cancer development. The purpose of this study was to investigate single nucleotide polymorphism of the vitamin D receptor gene and its possible relationship with colorectal cancer (CRC) in an Iranian population. METHODS: This investigation was a case control study. The samples were including 130 CRC patients and 130 controls referred to Taleghani hospital, Tehran. These individuals considering their pathological results are divided into two groups. Due to genotyping of vitamin D receptor (VDR) genotypes polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) was performed and restriction enzyme, Apa1, was used. FINDINGS: The frequencies of the GG, TG, and TT genotypes were 10%, 43.8% and 46% in healthy controls and 21.5%, 44.6% and 33.8% in colorectal cancer patients, respectively. Furthermore, frequency of T allele was 68%, 44%, and the C allele was 32% and 56% in the control group and colorectal cancer patients respectively.CONCLUSION: According to our finding, interestingly we could detect a reverse association between genotype 61888G>T and colorectal cancer.M Haghighi,SR MohebbiMA Pour Hoseingholi,MY Taleghani,SR FatemiMR ZaliBabol University of Medical Sciencesarticlecolorectal cancervitamin d receptor61888g>tMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 12, Iss 1, Pp 24-28 (2010)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	colorectal cancer vitamin d receptor 61888g>t Medicine R Medicine (General) R5-920
spellingShingle	colorectal cancer vitamin d receptor 61888g>t Medicine R Medicine (General) R5-920 M Haghighi, SR Mohebbi MA Pour Hoseingholi, MY Taleghani, SR Fatemi MR Zali Association of Allele 61888G>T Polymorphism VDR Gene and Colorectal Cancer
description	BACKGROUND AND OBJECTIVE: Colorectal cancer is the third most common cancer in the world and it is the fourth most common cancer that is a leading cause of cancer deaths. Polymorphisms of the vitamin D receptor (VDR) gene may influence colorectal cancer risk. The vitamin D receptor (VDR) is a crucial mediator for the cellular effects of vitamin D and additionally interacts with other cell-signaling pathways that influence cancer development. The purpose of this study was to investigate single nucleotide polymorphism of the vitamin D receptor gene and its possible relationship with colorectal cancer (CRC) in an Iranian population. METHODS: This investigation was a case control study. The samples were including 130 CRC patients and 130 controls referred to Taleghani hospital, Tehran. These individuals considering their pathological results are divided into two groups. Due to genotyping of vitamin D receptor (VDR) genotypes polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) was performed and restriction enzyme, Apa1, was used. FINDINGS: The frequencies of the GG, TG, and TT genotypes were 10%, 43.8% and 46% in healthy controls and 21.5%, 44.6% and 33.8% in colorectal cancer patients, respectively. Furthermore, frequency of T allele was 68%, 44%, and the C allele was 32% and 56% in the control group and colorectal cancer patients respectively.CONCLUSION: According to our finding, interestingly we could detect a reverse association between genotype 61888G>T and colorectal cancer.
format	article
author	M Haghighi, SR Mohebbi MA Pour Hoseingholi, MY Taleghani, SR Fatemi MR Zali
author_facet	M Haghighi, SR Mohebbi MA Pour Hoseingholi, MY Taleghani, SR Fatemi MR Zali
author_sort	M Haghighi,
title	Association of Allele 61888G>T Polymorphism VDR Gene and Colorectal Cancer
title_short	Association of Allele 61888G>T Polymorphism VDR Gene and Colorectal Cancer
title_full	Association of Allele 61888G>T Polymorphism VDR Gene and Colorectal Cancer
title_fullStr	Association of Allele 61888G>T Polymorphism VDR Gene and Colorectal Cancer
title_full_unstemmed	Association of Allele 61888G>T Polymorphism VDR Gene and Colorectal Cancer
title_sort	association of allele 61888g>t polymorphism vdr gene and colorectal cancer
publisher	Babol University of Medical Sciences
publishDate	2010
url	https://doaj.org/article/700e8d6512ae45fc9dd7a1bdb910be7d
work_keys_str_mv	AT mhaghighi associationofallele61888gtpolymorphismvdrgeneandcolorectalcancer AT srmohebbi associationofallele61888gtpolymorphismvdrgeneandcolorectalcancer AT mapourhoseingholi associationofallele61888gtpolymorphismvdrgeneandcolorectalcancer AT mytaleghani associationofallele61888gtpolymorphismvdrgeneandcolorectalcancer AT srfatemi associationofallele61888gtpolymorphismvdrgeneandcolorectalcancer AT mrzali associationofallele61888gtpolymorphismvdrgeneandcolorectalcancer
_version_	1718440295477018624

Association of Allele 61888G>T Polymorphism VDR Gene and Colorectal Cancer

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