LONG-TERM CHANGES OF INFLAMMATION MARKERS IN PATIENTS WITH NON-ST ELEVATION ACUTE CORONARY SYNDROME FOLLOWING CORONARY ARTERY BYPASS GRAFTING SURGERY

It was found that soluble intercellular adhesion molecule-1 (ICAM-1) and leukocyte levels in patients with non-ST elevation acute coronary syndrome exhibited a gradual decrease during follow-up period of 6 to 12 months after CABG, as compared with pre-treatment baseline rates. In addition, sICAM-1 l...

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Autores principales:	N. A. Gavricheva, K. V. Korzhenevskaya, G. V. Alekseeva, A. V. Panov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	acute coronary syndrome coronary bypass intercellular adhesion molecule-1 proinflammatory cytokines leukocytes Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/701004a954794b6d80722098294acc23
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spelling	oai:doaj.org-article:701004a954794b6d80722098294acc232021-11-18T08:03:43ZLONG-TERM CHANGES OF INFLAMMATION MARKERS IN PATIENTS WITH NON-ST ELEVATION ACUTE CORONARY SYNDROME FOLLOWING CORONARY ARTERY BYPASS GRAFTING SURGERY1563-06252313-741X10.15789/1563-0625-2014-2-183-188https://doaj.org/article/701004a954794b6d80722098294acc232014-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/684https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XIt was found that soluble intercellular adhesion molecule-1 (ICAM-1) and leukocyte levels in patients with non-ST elevation acute coronary syndrome exhibited a gradual decrease during follow-up period of 6 to 12 months after CABG, as compared with pre-treatment baseline rates. In addition, sICAM-1 level showed an increase at 48 month post-CABG, tending to pre-treatment values. The levels of tumor necrosis factor-alpha (TNFa) and interleukin-6 (IL-6) did not express any significant changes during the entire observation period. TNFα level in the patients with non-STEMI before surgery did not differ from the levels in the patients with stable ischemic heart disease (60.0±9.8 pg/ml and 51.0±6.8 pg/ml; p > 0.05). Serum TNFα level remained unchanged in the patients after CABG. Similar changes were found for IL-6, with no differences between initial levels in the patients with non-STEMI and those with stable coronary artery disease (34.5±3.6 pg/ml and 28.6±3.1 pg/ml; p > 0.05). The IL-6 levels remained virtually unchanged over the observation time. Therefore, the ambiguous results obtained in present study deserve further studies of the role of inflammatory mediators in different clinical forms of ischemic heart disease following CABG.N. A. GavrichevaK. V. KorzhenevskayaG. V. AlekseevaA. V. PanovSPb RAACIarticleacute coronary syndromecoronary bypassintercellular adhesion molecule-1proinflammatory cytokinesleukocytesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 2, Pp 183-188 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	acute coronary syndrome coronary bypass intercellular adhesion molecule-1 proinflammatory cytokines leukocytes Immunologic diseases. Allergy RC581-607
spellingShingle	acute coronary syndrome coronary bypass intercellular adhesion molecule-1 proinflammatory cytokines leukocytes Immunologic diseases. Allergy RC581-607 N. A. Gavricheva K. V. Korzhenevskaya G. V. Alekseeva A. V. Panov LONG-TERM CHANGES OF INFLAMMATION MARKERS IN PATIENTS WITH NON-ST ELEVATION ACUTE CORONARY SYNDROME FOLLOWING CORONARY ARTERY BYPASS GRAFTING SURGERY
description	It was found that soluble intercellular adhesion molecule-1 (ICAM-1) and leukocyte levels in patients with non-ST elevation acute coronary syndrome exhibited a gradual decrease during follow-up period of 6 to 12 months after CABG, as compared with pre-treatment baseline rates. In addition, sICAM-1 level showed an increase at 48 month post-CABG, tending to pre-treatment values. The levels of tumor necrosis factor-alpha (TNFa) and interleukin-6 (IL-6) did not express any significant changes during the entire observation period. TNFα level in the patients with non-STEMI before surgery did not differ from the levels in the patients with stable ischemic heart disease (60.0±9.8 pg/ml and 51.0±6.8 pg/ml; p > 0.05). Serum TNFα level remained unchanged in the patients after CABG. Similar changes were found for IL-6, with no differences between initial levels in the patients with non-STEMI and those with stable coronary artery disease (34.5±3.6 pg/ml and 28.6±3.1 pg/ml; p > 0.05). The IL-6 levels remained virtually unchanged over the observation time. Therefore, the ambiguous results obtained in present study deserve further studies of the role of inflammatory mediators in different clinical forms of ischemic heart disease following CABG.
format	article
author	N. A. Gavricheva K. V. Korzhenevskaya G. V. Alekseeva A. V. Panov
author_facet	N. A. Gavricheva K. V. Korzhenevskaya G. V. Alekseeva A. V. Panov
author_sort	N. A. Gavricheva
title	LONG-TERM CHANGES OF INFLAMMATION MARKERS IN PATIENTS WITH NON-ST ELEVATION ACUTE CORONARY SYNDROME FOLLOWING CORONARY ARTERY BYPASS GRAFTING SURGERY
title_short	LONG-TERM CHANGES OF INFLAMMATION MARKERS IN PATIENTS WITH NON-ST ELEVATION ACUTE CORONARY SYNDROME FOLLOWING CORONARY ARTERY BYPASS GRAFTING SURGERY
title_full	LONG-TERM CHANGES OF INFLAMMATION MARKERS IN PATIENTS WITH NON-ST ELEVATION ACUTE CORONARY SYNDROME FOLLOWING CORONARY ARTERY BYPASS GRAFTING SURGERY
title_fullStr	LONG-TERM CHANGES OF INFLAMMATION MARKERS IN PATIENTS WITH NON-ST ELEVATION ACUTE CORONARY SYNDROME FOLLOWING CORONARY ARTERY BYPASS GRAFTING SURGERY
title_full_unstemmed	LONG-TERM CHANGES OF INFLAMMATION MARKERS IN PATIENTS WITH NON-ST ELEVATION ACUTE CORONARY SYNDROME FOLLOWING CORONARY ARTERY BYPASS GRAFTING SURGERY
title_sort	long-term changes of inflammation markers in patients with non-st elevation acute coronary syndrome following coronary artery bypass grafting surgery
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/701004a954794b6d80722098294acc23
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LONG-TERM CHANGES OF INFLAMMATION MARKERS IN PATIENTS WITH NON-ST ELEVATION ACUTE CORONARY SYNDROME FOLLOWING CORONARY ARTERY BYPASS GRAFTING SURGERY

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