Pulmonary hypoplasia associated with congenital heart diseases: a fetal study.

<h4>Background</h4>Abnormalities of the fetal pulmonary vasculature may affect lung morphogenesis. Postnatal studies have suggested that pulmonary hypoplasia (PH) may be associated with congenital heart diseases (CHDs).<h4>Objective</h4>To determine the prevalence of PH assoc...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Isabelle Ruchonnet-Metrailler, Bettina Bessieres, Damien Bonnet, Shamila Vibhushan, Christophe Delacourt
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/701308db2f264f648e19dd35b05a2b9e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:701308db2f264f648e19dd35b05a2b9e
record_format	dspace
spelling	oai:doaj.org-article:701308db2f264f648e19dd35b05a2b9e2021-11-18T08:25:03ZPulmonary hypoplasia associated with congenital heart diseases: a fetal study.1932-620310.1371/journal.pone.0093557https://doaj.org/article/701308db2f264f648e19dd35b05a2b9e2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24699523/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Abnormalities of the fetal pulmonary vasculature may affect lung morphogenesis. Postnatal studies have suggested that pulmonary hypoplasia (PH) may be associated with congenital heart diseases (CHDs).<h4>Objective</h4>To determine the prevalence of PH associated with CHDs, and to evaluate whether CHDs with right outflow obstruction were associated with the highest risk of lung growth impairment.<h4>Methods</h4>Between January 2006 and December 2010, fetuses with CHD obtained following the termination of pregnancies due to fetal abnormalities were examined in a prospective manner for the detection of heart and lung defects. CHDs were classified into five pathophysiological groups. Lung weight (LW), body weight (BW), and LW/BW ratio were analyzed for each case. The expression of CD31 and VEGF in the lung was evaluated by immunohistochemistry.<h4>Results</h4>Fetuses with CHDs and right outflow obstruction had significantly lower LW for a given BW, and significantly lower LW/BW ratios for a given gestational age. When defining PH as a fetal LW/BW ratio <0.015 before 28 weeks, and <0.012 after 28 weeks, PH was detected in 15 of the 119 fetuses analyzed (13%). It was significantly associated with CHD with right outflow obstruction, independently of chromosomal abnormalities and associated extracardiac abnormalities (p<0.03). Right outflow obstruction was detected in 60% of the fetuses with CHD and PH, but in only 32% of those with CHD but no PH. In fetuses with right outflow obstruction, no difference was observed between those with PH and those without PH, in terms of the ratio of pulmonary artery diameter to aortic diameter, lung CD31 expression, or lung VEGF expression.<h4>Conclusion</h4>CHDs with right outflow obstruction are a significant risk factor for prenatally acquired PH. The occurrence of fetal PH is not correlated with abnormalities of the pulmonary vasculature, suggesting the involvement of perfusion-independent mechanisms.Isabelle Ruchonnet-MetraillerBettina BessieresDamien BonnetShamila VibhushanChristophe DelacourtPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e93557 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Isabelle Ruchonnet-Metrailler Bettina Bessieres Damien Bonnet Shamila Vibhushan Christophe Delacourt Pulmonary hypoplasia associated with congenital heart diseases: a fetal study.
description	<h4>Background</h4>Abnormalities of the fetal pulmonary vasculature may affect lung morphogenesis. Postnatal studies have suggested that pulmonary hypoplasia (PH) may be associated with congenital heart diseases (CHDs).<h4>Objective</h4>To determine the prevalence of PH associated with CHDs, and to evaluate whether CHDs with right outflow obstruction were associated with the highest risk of lung growth impairment.<h4>Methods</h4>Between January 2006 and December 2010, fetuses with CHD obtained following the termination of pregnancies due to fetal abnormalities were examined in a prospective manner for the detection of heart and lung defects. CHDs were classified into five pathophysiological groups. Lung weight (LW), body weight (BW), and LW/BW ratio were analyzed for each case. The expression of CD31 and VEGF in the lung was evaluated by immunohistochemistry.<h4>Results</h4>Fetuses with CHDs and right outflow obstruction had significantly lower LW for a given BW, and significantly lower LW/BW ratios for a given gestational age. When defining PH as a fetal LW/BW ratio <0.015 before 28 weeks, and <0.012 after 28 weeks, PH was detected in 15 of the 119 fetuses analyzed (13%). It was significantly associated with CHD with right outflow obstruction, independently of chromosomal abnormalities and associated extracardiac abnormalities (p<0.03). Right outflow obstruction was detected in 60% of the fetuses with CHD and PH, but in only 32% of those with CHD but no PH. In fetuses with right outflow obstruction, no difference was observed between those with PH and those without PH, in terms of the ratio of pulmonary artery diameter to aortic diameter, lung CD31 expression, or lung VEGF expression.<h4>Conclusion</h4>CHDs with right outflow obstruction are a significant risk factor for prenatally acquired PH. The occurrence of fetal PH is not correlated with abnormalities of the pulmonary vasculature, suggesting the involvement of perfusion-independent mechanisms.
format	article
author	Isabelle Ruchonnet-Metrailler Bettina Bessieres Damien Bonnet Shamila Vibhushan Christophe Delacourt
author_facet	Isabelle Ruchonnet-Metrailler Bettina Bessieres Damien Bonnet Shamila Vibhushan Christophe Delacourt
author_sort	Isabelle Ruchonnet-Metrailler
title	Pulmonary hypoplasia associated with congenital heart diseases: a fetal study.
title_short	Pulmonary hypoplasia associated with congenital heart diseases: a fetal study.
title_full	Pulmonary hypoplasia associated with congenital heart diseases: a fetal study.
title_fullStr	Pulmonary hypoplasia associated with congenital heart diseases: a fetal study.
title_full_unstemmed	Pulmonary hypoplasia associated with congenital heart diseases: a fetal study.
title_sort	pulmonary hypoplasia associated with congenital heart diseases: a fetal study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/701308db2f264f648e19dd35b05a2b9e
work_keys_str_mv	AT isabelleruchonnetmetrailler pulmonaryhypoplasiaassociatedwithcongenitalheartdiseasesafetalstudy AT bettinabessieres pulmonaryhypoplasiaassociatedwithcongenitalheartdiseasesafetalstudy AT damienbonnet pulmonaryhypoplasiaassociatedwithcongenitalheartdiseasesafetalstudy AT shamilavibhushan pulmonaryhypoplasiaassociatedwithcongenitalheartdiseasesafetalstudy AT christophedelacourt pulmonaryhypoplasiaassociatedwithcongenitalheartdiseasesafetalstudy
_version_	1718421808950018048

Pulmonary hypoplasia associated with congenital heart diseases: a fetal study.

Ejemplares similares