Comparative Study of Cognitive Function Between Treatment-Resistant Depressive Patients and First-Episode Depressive Patients

Dongping Rao,1 Guiyun Xu,1 Zenghong Lu,2 Huiwei Liang,1 Kangguang Lin,1 Muni Tang1 1Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, People’s Republic of China; 2The First Affiliated Hospital of Gannan Medical Un...

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Autores principales:	Rao D, Xu G, Lu Z, Liang H, Lin K, Tang M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	treatment-resistant depression first-episode depression cognitive dysfunction Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/7017d26a2ce4435e9ee8dd326cebd392
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spelling	oai:doaj.org-article:7017d26a2ce4435e9ee8dd326cebd3922021-12-02T02:26:21ZComparative Study of Cognitive Function Between Treatment-Resistant Depressive Patients and First-Episode Depressive Patients1178-2021https://doaj.org/article/7017d26a2ce4435e9ee8dd326cebd3922019-12-01T00:00:00Zhttps://www.dovepress.com/comparative-study-of-cognitive-function-between-treatment-resistant-de-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Dongping Rao,1 Guiyun Xu,1 Zenghong Lu,2 Huiwei Liang,1 Kangguang Lin,1 Muni Tang1 1Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, People’s Republic of China; 2The First Affiliated Hospital of Gannan Medical University, Jiangxi, People’s Republic of ChinaCorrespondence: Muni TangDepartment of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Mingxin Road #36, Liwan District, Guangzhou 510370, People’s Republic of ChinaTel +86-20-81268720Fax +86-20-81891391Email munitang@163.comObjective: Despite reports of cognitive dysfunction during the acute phase of depression, there is a lack of studies in patients with treatment-resistant depression (TRD). The aim of this study was to investigate the cognitive function profile of TRD and compare cognitive dysfunction between subjects with TRD and first-episode depression.Patients and methods: The study included 31 patients with TRD and 53 with first-episode depression. Cognitive function was assessed by a series of neuropsychological tools such as the verbal fluency test, Modified Wisconsin Card Sorting Test (M-WCST), Tower of Hanoi test, Chinese-revision of the Wechsler Adult Intelligence Scale (WAIS-RC), and Trail Making Test A and B.Results: There were no significant demographic differences between the TRD, first-episode depression, and normal control groups (gender, age, years of education). The full-scale, verbal, and performance intelligence quotients measured with the WAIS-RC were also not significantly different (p>0.05). The normal group scores were all significantly better than TRD and first-episode depression, and the TRD group performed significantly worse than subjects with first-episode depression on Trail Making Test B, two WCST subscales, and the profile score of the Tower of Hanoi test (all p<0.05).Conclusion: Patients with depression exhibited global impairments in cognitive function, and these were more common in TRD. Poor executive function may play an important role in TRD.Keywords: treatment-resistant depression, first-episode depression, cognitive dysfunctionRao DXu GLu ZLiang HLin KTang MDove Medical Pressarticletreatment-resistant depressionfirst-episode depressioncognitive dysfunctionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 3411-3417 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	treatment-resistant depression first-episode depression cognitive dysfunction Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	treatment-resistant depression first-episode depression cognitive dysfunction Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Rao D Xu G Lu Z Liang H Lin K Tang M Comparative Study of Cognitive Function Between Treatment-Resistant Depressive Patients and First-Episode Depressive Patients
description	Dongping Rao,1 Guiyun Xu,1 Zenghong Lu,2 Huiwei Liang,1 Kangguang Lin,1 Muni Tang1 1Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, People’s Republic of China; 2The First Affiliated Hospital of Gannan Medical University, Jiangxi, People’s Republic of ChinaCorrespondence: Muni TangDepartment of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Mingxin Road #36, Liwan District, Guangzhou 510370, People’s Republic of ChinaTel +86-20-81268720Fax +86-20-81891391Email munitang@163.comObjective: Despite reports of cognitive dysfunction during the acute phase of depression, there is a lack of studies in patients with treatment-resistant depression (TRD). The aim of this study was to investigate the cognitive function profile of TRD and compare cognitive dysfunction between subjects with TRD and first-episode depression.Patients and methods: The study included 31 patients with TRD and 53 with first-episode depression. Cognitive function was assessed by a series of neuropsychological tools such as the verbal fluency test, Modified Wisconsin Card Sorting Test (M-WCST), Tower of Hanoi test, Chinese-revision of the Wechsler Adult Intelligence Scale (WAIS-RC), and Trail Making Test A and B.Results: There were no significant demographic differences between the TRD, first-episode depression, and normal control groups (gender, age, years of education). The full-scale, verbal, and performance intelligence quotients measured with the WAIS-RC were also not significantly different (p>0.05). The normal group scores were all significantly better than TRD and first-episode depression, and the TRD group performed significantly worse than subjects with first-episode depression on Trail Making Test B, two WCST subscales, and the profile score of the Tower of Hanoi test (all p<0.05).Conclusion: Patients with depression exhibited global impairments in cognitive function, and these were more common in TRD. Poor executive function may play an important role in TRD.Keywords: treatment-resistant depression, first-episode depression, cognitive dysfunction
format	article
author	Rao D Xu G Lu Z Liang H Lin K Tang M
author_facet	Rao D Xu G Lu Z Liang H Lin K Tang M
author_sort	Rao D
title	Comparative Study of Cognitive Function Between Treatment-Resistant Depressive Patients and First-Episode Depressive Patients
title_short	Comparative Study of Cognitive Function Between Treatment-Resistant Depressive Patients and First-Episode Depressive Patients
title_full	Comparative Study of Cognitive Function Between Treatment-Resistant Depressive Patients and First-Episode Depressive Patients
title_fullStr	Comparative Study of Cognitive Function Between Treatment-Resistant Depressive Patients and First-Episode Depressive Patients
title_full_unstemmed	Comparative Study of Cognitive Function Between Treatment-Resistant Depressive Patients and First-Episode Depressive Patients
title_sort	comparative study of cognitive function between treatment-resistant depressive patients and first-episode depressive patients
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/7017d26a2ce4435e9ee8dd326cebd392
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Comparative Study of Cognitive Function Between Treatment-Resistant Depressive Patients and First-Episode Depressive Patients

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