Photosensitive tyrosine analogues unravel site-dependent phosphorylation in TrkA initiated MAPK/ERK signaling

Using genetic code expansion, Zhao, Shi et al. generate light-sensitive tyrosine analogues to obtain insights into the activation of the NGF receptor, TrkA. They identify light-sensitive and NGF-insensitive phosphorylation sites, validating the approach and providing insights into TrkA signaling

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Autores principales:	Shu Zhao, Jia Shi, Guohua Yu, Dali Li, Meng Wang, Chonggang Yuan, Huihui Zhou, Amirabbas Parizadeh, Zhenlin Li, Min-Xin Guan, Shixin Ye
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/701e78398bee489f8d0e44ae55b19fcc
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spelling	oai:doaj.org-article:701e78398bee489f8d0e44ae55b19fcc2021-12-02T16:19:52ZPhotosensitive tyrosine analogues unravel site-dependent phosphorylation in TrkA initiated MAPK/ERK signaling10.1038/s42003-020-01396-02399-3642https://doaj.org/article/701e78398bee489f8d0e44ae55b19fcc2020-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01396-0https://doaj.org/toc/2399-3642Using genetic code expansion, Zhao, Shi et al. generate light-sensitive tyrosine analogues to obtain insights into the activation of the NGF receptor, TrkA. They identify light-sensitive and NGF-insensitive phosphorylation sites, validating the approach and providing insights into TrkA signalingShu ZhaoJia ShiGuohua YuDali LiMeng WangChonggang YuanHuihui ZhouAmirabbas ParizadehZhenlin LiMin-Xin GuanShixin YeNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 3, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Shu Zhao Jia Shi Guohua Yu Dali Li Meng Wang Chonggang Yuan Huihui Zhou Amirabbas Parizadeh Zhenlin Li Min-Xin Guan Shixin Ye Photosensitive tyrosine analogues unravel site-dependent phosphorylation in TrkA initiated MAPK/ERK signaling
description	Using genetic code expansion, Zhao, Shi et al. generate light-sensitive tyrosine analogues to obtain insights into the activation of the NGF receptor, TrkA. They identify light-sensitive and NGF-insensitive phosphorylation sites, validating the approach and providing insights into TrkA signaling
format	article
author	Shu Zhao Jia Shi Guohua Yu Dali Li Meng Wang Chonggang Yuan Huihui Zhou Amirabbas Parizadeh Zhenlin Li Min-Xin Guan Shixin Ye
author_facet	Shu Zhao Jia Shi Guohua Yu Dali Li Meng Wang Chonggang Yuan Huihui Zhou Amirabbas Parizadeh Zhenlin Li Min-Xin Guan Shixin Ye
author_sort	Shu Zhao
title	Photosensitive tyrosine analogues unravel site-dependent phosphorylation in TrkA initiated MAPK/ERK signaling
title_short	Photosensitive tyrosine analogues unravel site-dependent phosphorylation in TrkA initiated MAPK/ERK signaling
title_full	Photosensitive tyrosine analogues unravel site-dependent phosphorylation in TrkA initiated MAPK/ERK signaling
title_fullStr	Photosensitive tyrosine analogues unravel site-dependent phosphorylation in TrkA initiated MAPK/ERK signaling
title_full_unstemmed	Photosensitive tyrosine analogues unravel site-dependent phosphorylation in TrkA initiated MAPK/ERK signaling
title_sort	photosensitive tyrosine analogues unravel site-dependent phosphorylation in trka initiated mapk/erk signaling
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/701e78398bee489f8d0e44ae55b19fcc
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Photosensitive tyrosine analogues unravel site-dependent phosphorylation in TrkA initiated MAPK/ERK signaling

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