The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth

Perturbations in ribosome biogenesis affect development and increase cancer susceptibility. Here, the authors show that hCINAP is required for 18S rRNA processing, is highly expressed in cancers, and promotes cancer cell growth by upregulating the translation of cancer-associated genes.

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Autores principales:	Dongmei Bai, Jinfang Zhang, Tingting Li, Runlai Hang, Yong Liu, Yonglu Tian, Dadu Huang, Linglong Qu, Xiaofeng Cao, Jiafu Ji, Xiaofeng Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/70202b76d3064669a4032452fc93fbae
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spelling	oai:doaj.org-article:70202b76d3064669a4032452fc93fbae2021-12-02T15:35:46ZThe ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth10.1038/ncomms123102041-1723https://doaj.org/article/70202b76d3064669a4032452fc93fbae2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12310https://doaj.org/toc/2041-1723Perturbations in ribosome biogenesis affect development and increase cancer susceptibility. Here, the authors show that hCINAP is required for 18S rRNA processing, is highly expressed in cancers, and promotes cancer cell growth by upregulating the translation of cancer-associated genes.Dongmei BaiJinfang ZhangTingting LiRunlai HangYong LiuYonglu TianDadu HuangLinglong QuXiaofeng CaoJiafu JiXiaofeng ZhengNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dongmei Bai Jinfang Zhang Tingting Li Runlai Hang Yong Liu Yonglu Tian Dadu Huang Linglong Qu Xiaofeng Cao Jiafu Ji Xiaofeng Zheng The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth
description	Perturbations in ribosome biogenesis affect development and increase cancer susceptibility. Here, the authors show that hCINAP is required for 18S rRNA processing, is highly expressed in cancers, and promotes cancer cell growth by upregulating the translation of cancer-associated genes.
format	article
author	Dongmei Bai Jinfang Zhang Tingting Li Runlai Hang Yong Liu Yonglu Tian Dadu Huang Linglong Qu Xiaofeng Cao Jiafu Ji Xiaofeng Zheng
author_facet	Dongmei Bai Jinfang Zhang Tingting Li Runlai Hang Yong Liu Yonglu Tian Dadu Huang Linglong Qu Xiaofeng Cao Jiafu Ji Xiaofeng Zheng
author_sort	Dongmei Bai
title	The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth
title_short	The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth
title_full	The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth
title_fullStr	The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth
title_full_unstemmed	The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth
title_sort	atpase hcinap regulates 18s rrna processing and is essential for embryogenesis and tumour growth
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/70202b76d3064669a4032452fc93fbae
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The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth

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