The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth

The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth

Perturbations in ribosome biogenesis affect development and increase cancer susceptibility. Here, the authors show that hCINAP is required for 18S rRNA processing, is highly expressed in cancers, and promotes cancer cell growth by upregulating the translation of cancer-associated genes.

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Detalles Bibliográficos
Autores principales: Dongmei Bai, Jinfang Zhang, Tingting Li, Runlai Hang, Yong Liu, Yonglu Tian, Dadu Huang, Linglong Qu, Xiaofeng Cao, Jiafu Ji, Xiaofeng Zheng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
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Acceso en línea:https://doaj.org/article/70202b76d3064669a4032452fc93fbae
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