Epigenetic Approach to PTSD: In the Aspects of Rat Models

Posttraumatic stress disorder (PTSD) is a stress-related mental disorder and develops after exposure to life-threatening traumatic experiences. The risk factors of PTSD included genetic factors; alterations in hypothalamic–pituitary–adrenal (HPA) axis; neurotrophic, serotonergic, dopaminergic, and c...

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Autores principales:	Asli Aykac, Rasime Kalkan
Formato:	article
Lenguaje:	EN
Publicado:	Georg Thieme Verlag KG 2021
Materias:	ptsd epigenetics methylation rat studies Genetics QH426-470 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/702c34172446416a9fcb761cb1c073dd
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spelling	oai:doaj.org-article:702c34172446416a9fcb761cb1c073dd2021-11-12T00:01:31ZEpigenetic Approach to PTSD: In the Aspects of Rat Models2699-940410.1055/s-0041-1736633https://doaj.org/article/702c34172446416a9fcb761cb1c073dd2021-11-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1736633https://doaj.org/toc/2699-9404Posttraumatic stress disorder (PTSD) is a stress-related mental disorder and develops after exposure to life-threatening traumatic experiences. The risk factors of PTSD included genetic factors; alterations in hypothalamic–pituitary–adrenal (HPA) axis; neurotrophic, serotonergic, dopaminergic, and catecholaminergic systems; and a variety of environmental factors, such as war, accident, natural disaster, pandemic, physical, or sexual abuse, that cause stress or trauma in individuals. To be able to understand the molecular background of PTSD, rodent animal models are widely used by researchers. When looking for a solution for PTSD, it is important to consider preexisting genetic risk factors and physiological, molecular, and biochemical processes caused by trauma that may cause susceptibility to this disorder. In studies, it is reported that epigenetic mechanisms play important roles in the biological response affected by environmental factors, as well as the task of programming cell identity. In this article, we provided an overview of the role of epigenetic modifications in understanding the biology of PTSD. We also summarized the data from animal studies and their importance during the investigation of PTSD. This study shed light on the epigenetic background of stress and PTSD.Asli AykacRasime KalkanGeorg Thieme Verlag KGarticleptsdepigeneticsmethylationrat studiesGeneticsQH426-470Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENGlobal Medical Genetics (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ptsd epigenetics methylation rat studies Genetics QH426-470 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	ptsd epigenetics methylation rat studies Genetics QH426-470 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Asli Aykac Rasime Kalkan Epigenetic Approach to PTSD: In the Aspects of Rat Models
description	Posttraumatic stress disorder (PTSD) is a stress-related mental disorder and develops after exposure to life-threatening traumatic experiences. The risk factors of PTSD included genetic factors; alterations in hypothalamic–pituitary–adrenal (HPA) axis; neurotrophic, serotonergic, dopaminergic, and catecholaminergic systems; and a variety of environmental factors, such as war, accident, natural disaster, pandemic, physical, or sexual abuse, that cause stress or trauma in individuals. To be able to understand the molecular background of PTSD, rodent animal models are widely used by researchers. When looking for a solution for PTSD, it is important to consider preexisting genetic risk factors and physiological, molecular, and biochemical processes caused by trauma that may cause susceptibility to this disorder. In studies, it is reported that epigenetic mechanisms play important roles in the biological response affected by environmental factors, as well as the task of programming cell identity. In this article, we provided an overview of the role of epigenetic modifications in understanding the biology of PTSD. We also summarized the data from animal studies and their importance during the investigation of PTSD. This study shed light on the epigenetic background of stress and PTSD.
format	article
author	Asli Aykac Rasime Kalkan
author_facet	Asli Aykac Rasime Kalkan
author_sort	Asli Aykac
title	Epigenetic Approach to PTSD: In the Aspects of Rat Models
title_short	Epigenetic Approach to PTSD: In the Aspects of Rat Models
title_full	Epigenetic Approach to PTSD: In the Aspects of Rat Models
title_fullStr	Epigenetic Approach to PTSD: In the Aspects of Rat Models
title_full_unstemmed	Epigenetic Approach to PTSD: In the Aspects of Rat Models
title_sort	epigenetic approach to ptsd: in the aspects of rat models
publisher	Georg Thieme Verlag KG
publishDate	2021
url	https://doaj.org/article/702c34172446416a9fcb761cb1c073dd
work_keys_str_mv	AT asliaykac epigeneticapproachtoptsdintheaspectsofratmodels AT rasimekalkan epigeneticapproachtoptsdintheaspectsofratmodels
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Epigenetic Approach to PTSD: In the Aspects of Rat Models

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