Emergence and Global Dissemination of Host-Specific <italic toggle="yes">Streptococcus agalactiae</italic> Clones

ABSTRACT To examine the global diversity of Streptococcus agalactiae (group B streptococci [GBS]) and to elucidate the evolutionary processes that determine its population genetics structure and the reported changes in host tropism and infection epidemiology, we examined a collection of 238 bovine a...

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Autores principales:	Uffe B. Skov Sørensen, Knud Poulsen, Claudia Ghezzo, Immaculada Margarit, Mogens Kilian
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2010
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/702c49824f254a33a9e86418c8c2f510
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spelling	oai:doaj.org-article:702c49824f254a33a9e86418c8c2f5102021-11-15T15:38:16ZEmergence and Global Dissemination of Host-Specific <italic toggle="yes">Streptococcus agalactiae</italic> Clones10.1128/mBio.00178-102150-7511https://doaj.org/article/702c49824f254a33a9e86418c8c2f5102010-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00178-10https://doaj.org/toc/2150-7511ABSTRACT To examine the global diversity of Streptococcus agalactiae (group B streptococci [GBS]) and to elucidate the evolutionary processes that determine its population genetics structure and the reported changes in host tropism and infection epidemiology, we examined a collection of 238 bovine and human isolates from nine countries on five continents. Phylogenetic analysis based on the sequences of 15 housekeeping genes combined with patterns of virulence-associated traits identified a genetically heterogeneous core population from which virulent lineages occasionally emerge as a result of recombination affecting major segments of the genome. Such lineages, like clonal complex 17 (CC17) and two distinct clusters of CC23, are exclusively adapted to either humans or cattle and successfully spread globally. The recent emergence and expansion of the human-associated and highly virulent sequence type 17 (ST17) could conceivably account, in part, for the increased prevalence of neonatal GBS infections after 1960. The composite structure of the S. agalactiae genome invalidates phylogenetic inferences exclusively based on multilocus sequence typing (MLST) data and thereby the previously reported conclusion that the human-associated CC17 emerged from the bovine-associated CC67. IMPORTANCE Group B streptococci (GBS) (Streptococcus agalactiae) have long been recognized as important causes of mastitis in cattle. After 1960, GBS also became the most prevalent cause of invasive and often fatal infections in newborns. At the same time, GBS are carried by a substantial proportion of healthy individuals. The aims of this study were to elucidate the genetic mechanisms that lead to diversification of the GBS population and to examine the relationship between virulence and host preference of evolutionary lineages of GBS. Genetic analysis of GBS isolates from worldwide sources demonstrated epidemic clones adapted specifically to either the human or bovine host. Such clones seem to emerge from a genetically heterogeneous core population as a result of recombination affecting major segments of the genome. Emergence and global spread of certain clones explain, in part, the change in epidemiology of GBS disease and may have implications for prevention.Uffe B. Skov SørensenKnud PoulsenClaudia GhezzoImmaculada MargaritMogens KilianAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 1, Iss 3 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Uffe B. Skov Sørensen Knud Poulsen Claudia Ghezzo Immaculada Margarit Mogens Kilian Emergence and Global Dissemination of Host-Specific <italic toggle="yes">Streptococcus agalactiae</italic> Clones
description	ABSTRACT To examine the global diversity of Streptococcus agalactiae (group B streptococci [GBS]) and to elucidate the evolutionary processes that determine its population genetics structure and the reported changes in host tropism and infection epidemiology, we examined a collection of 238 bovine and human isolates from nine countries on five continents. Phylogenetic analysis based on the sequences of 15 housekeeping genes combined with patterns of virulence-associated traits identified a genetically heterogeneous core population from which virulent lineages occasionally emerge as a result of recombination affecting major segments of the genome. Such lineages, like clonal complex 17 (CC17) and two distinct clusters of CC23, are exclusively adapted to either humans or cattle and successfully spread globally. The recent emergence and expansion of the human-associated and highly virulent sequence type 17 (ST17) could conceivably account, in part, for the increased prevalence of neonatal GBS infections after 1960. The composite structure of the S. agalactiae genome invalidates phylogenetic inferences exclusively based on multilocus sequence typing (MLST) data and thereby the previously reported conclusion that the human-associated CC17 emerged from the bovine-associated CC67. IMPORTANCE Group B streptococci (GBS) (Streptococcus agalactiae) have long been recognized as important causes of mastitis in cattle. After 1960, GBS also became the most prevalent cause of invasive and often fatal infections in newborns. At the same time, GBS are carried by a substantial proportion of healthy individuals. The aims of this study were to elucidate the genetic mechanisms that lead to diversification of the GBS population and to examine the relationship between virulence and host preference of evolutionary lineages of GBS. Genetic analysis of GBS isolates from worldwide sources demonstrated epidemic clones adapted specifically to either the human or bovine host. Such clones seem to emerge from a genetically heterogeneous core population as a result of recombination affecting major segments of the genome. Emergence and global spread of certain clones explain, in part, the change in epidemiology of GBS disease and may have implications for prevention.
format	article
author	Uffe B. Skov Sørensen Knud Poulsen Claudia Ghezzo Immaculada Margarit Mogens Kilian
author_facet	Uffe B. Skov Sørensen Knud Poulsen Claudia Ghezzo Immaculada Margarit Mogens Kilian
author_sort	Uffe B. Skov Sørensen
title	Emergence and Global Dissemination of Host-Specific <italic toggle="yes">Streptococcus agalactiae</italic> Clones
title_short	Emergence and Global Dissemination of Host-Specific <italic toggle="yes">Streptococcus agalactiae</italic> Clones
title_full	Emergence and Global Dissemination of Host-Specific <italic toggle="yes">Streptococcus agalactiae</italic> Clones
title_fullStr	Emergence and Global Dissemination of Host-Specific <italic toggle="yes">Streptococcus agalactiae</italic> Clones
title_full_unstemmed	Emergence and Global Dissemination of Host-Specific <italic toggle="yes">Streptococcus agalactiae</italic> Clones
title_sort	emergence and global dissemination of host-specific <italic toggle="yes">streptococcus agalactiae</italic> clones
publisher	American Society for Microbiology
publishDate	2010
url	https://doaj.org/article/702c49824f254a33a9e86418c8c2f510
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Emergence and Global Dissemination of Host-Specific <italic toggle="yes">Streptococcus agalactiae</italic> Clones

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