Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons

Revathy Munuswamy,1,&ast; Jana De Brandt,2,&ast; Chris Burtin,2 Wim Derave,3 Joseph Aumann,4 Martijn A Spruit,5,6,&ast; Luc Michiels1,&ast; 1Faculty of Medicine and Life Sciences, Biomedical Research Institute BIOMED, Hasselt University, Hasselt, Belgium; 2Faculty of Rehabilitation S...

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Autores principales:	Munuswamy R, De Brandt J, Burtin C, Derave W, Aumann J, Spruit MA, Michiels L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	copd low-grade systemic inflammation pcrp mcrp Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/702f89a8cf074e5ab0c42dfa33f7eaf7
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spelling	oai:doaj.org-article:702f89a8cf074e5ab0c42dfa33f7eaf72021-12-02T19:11:49ZMonomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons1178-7031https://doaj.org/article/702f89a8cf074e5ab0c42dfa33f7eaf72021-09-01T00:00:00Zhttps://www.dovepress.com/monomeric-crp-is-elevated-in-patients-with-copd-compared-to-non-copd-c-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Revathy Munuswamy,1,&ast; Jana De Brandt,2,&ast; Chris Burtin,2 Wim Derave,3 Joseph Aumann,4 Martijn A Spruit,5,6,&ast; Luc Michiels1,&ast; 1Faculty of Medicine and Life Sciences, Biomedical Research Institute BIOMED, Hasselt University, Hasselt, Belgium; 2Faculty of Rehabilitation Sciences, Rehabilitation Research Center REVAL, Biomedical Research Institute BIOMED, Hasselt University, Hasselt, Belgium; 3Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium; 4Department of Pneumology, Jessa Hospital, Hasselt, Belgium; 5Department of Research and Development, CIRO, Horn, the Netherlands; 6Department of Respiratory Medicine, Maastricht University Medical Centre, Faculty of Health, Medicine and Life Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht, the Netherlands&ast;These authors contributed equally to this workCorrespondence: Luc Michiels Email luc.michiels@uhasselt.beAbstract: Chronic low-grade systemic inflammation is frequently observed in patients with chronic obstructive pulmonary disease (COPD), e.g., elevated pentameric CRP (pCRP). However, pCRP can dissociate to form monomeric CRP (mCRP) which exhibits a clear pro-inflammatory behaviour in contrast to the more anti-inflammatory properties of pCRP. Therefore, mCRP may be an informative biomarker to demonstrate chronic low-grade systemic inflammation. This was confirmed by analysing serum samples from 38 patients with COPD and 18 non-COPD control persons (NCCP). mCRP was significantly elevated in patients with COPD vs. NCCP, indicating that mCRP might be considered as a new sensitive marker of chronic low-grade systemic inflammation.Keywords: COPD, low-grade systemic inflammation, pCRP, mCRPMunuswamy RDe Brandt JBurtin CDerave WAumann JSpruit MAMichiels LDove Medical Pressarticlecopdlow-grade systemic inflammationpcrpmcrpPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 4503-4507 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	copd low-grade systemic inflammation pcrp mcrp Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	copd low-grade systemic inflammation pcrp mcrp Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Munuswamy R De Brandt J Burtin C Derave W Aumann J Spruit MA Michiels L Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons
description	Revathy Munuswamy,1,&ast; Jana De Brandt,2,&ast; Chris Burtin,2 Wim Derave,3 Joseph Aumann,4 Martijn A Spruit,5,6,&ast; Luc Michiels1,&ast; 1Faculty of Medicine and Life Sciences, Biomedical Research Institute BIOMED, Hasselt University, Hasselt, Belgium; 2Faculty of Rehabilitation Sciences, Rehabilitation Research Center REVAL, Biomedical Research Institute BIOMED, Hasselt University, Hasselt, Belgium; 3Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium; 4Department of Pneumology, Jessa Hospital, Hasselt, Belgium; 5Department of Research and Development, CIRO, Horn, the Netherlands; 6Department of Respiratory Medicine, Maastricht University Medical Centre, Faculty of Health, Medicine and Life Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht, the Netherlands&ast;These authors contributed equally to this workCorrespondence: Luc Michiels Email luc.michiels@uhasselt.beAbstract: Chronic low-grade systemic inflammation is frequently observed in patients with chronic obstructive pulmonary disease (COPD), e.g., elevated pentameric CRP (pCRP). However, pCRP can dissociate to form monomeric CRP (mCRP) which exhibits a clear pro-inflammatory behaviour in contrast to the more anti-inflammatory properties of pCRP. Therefore, mCRP may be an informative biomarker to demonstrate chronic low-grade systemic inflammation. This was confirmed by analysing serum samples from 38 patients with COPD and 18 non-COPD control persons (NCCP). mCRP was significantly elevated in patients with COPD vs. NCCP, indicating that mCRP might be considered as a new sensitive marker of chronic low-grade systemic inflammation.Keywords: COPD, low-grade systemic inflammation, pCRP, mCRP
format	article
author	Munuswamy R De Brandt J Burtin C Derave W Aumann J Spruit MA Michiels L
author_facet	Munuswamy R De Brandt J Burtin C Derave W Aumann J Spruit MA Michiels L
author_sort	Munuswamy R
title	Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons
title_short	Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons
title_full	Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons
title_fullStr	Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons
title_full_unstemmed	Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons
title_sort	monomeric crp is elevated in patients with copd compared to non-copd control persons
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/702f89a8cf074e5ab0c42dfa33f7eaf7
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Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons

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