Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope

Structure determination of glycosylated HIV-1 envelope (Env) trimers complexed with broadly neutralizing antibodies (bNAbs) promotes a better understanding of bNAb epitopes. Here the authors present the structures of natively-glycosylated Env in complex with the highly-potent bNAb BG18, which is of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Christopher O. Barnes, Harry B. Gristick, Natalia T. Freund, Amelia Escolano, Artem Y. Lyubimov, Harald Hartweger, Anthony P. West, Aina E. Cohen, Michel C. Nussenzweig, Pamela J. Bjorkman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7030291af4434b7f82b5c09a827a0481
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7030291af4434b7f82b5c09a827a0481
record_format	dspace
spelling	oai:doaj.org-article:7030291af4434b7f82b5c09a827a04812021-12-02T15:34:38ZStructural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope10.1038/s41467-018-03632-y2041-1723https://doaj.org/article/7030291af4434b7f82b5c09a827a04812018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03632-yhttps://doaj.org/toc/2041-1723Structure determination of glycosylated HIV-1 envelope (Env) trimers complexed with broadly neutralizing antibodies (bNAbs) promotes a better understanding of bNAb epitopes. Here the authors present the structures of natively-glycosylated Env in complex with the highly-potent bNAb BG18, which is of interest for HIV-1 vaccine development.Christopher O. BarnesHarry B. GristickNatalia T. FreundAmelia EscolanoArtem Y. LyubimovHarald HartwegerAnthony P. WestAina E. CohenMichel C. NussenzweigPamela J. BjorkmanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christopher O. Barnes Harry B. Gristick Natalia T. Freund Amelia Escolano Artem Y. Lyubimov Harald Hartweger Anthony P. West Aina E. Cohen Michel C. Nussenzweig Pamela J. Bjorkman Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope
description	Structure determination of glycosylated HIV-1 envelope (Env) trimers complexed with broadly neutralizing antibodies (bNAbs) promotes a better understanding of bNAb epitopes. Here the authors present the structures of natively-glycosylated Env in complex with the highly-potent bNAb BG18, which is of interest for HIV-1 vaccine development.
format	article
author	Christopher O. Barnes Harry B. Gristick Natalia T. Freund Amelia Escolano Artem Y. Lyubimov Harald Hartweger Anthony P. West Aina E. Cohen Michel C. Nussenzweig Pamela J. Bjorkman
author_facet	Christopher O. Barnes Harry B. Gristick Natalia T. Freund Amelia Escolano Artem Y. Lyubimov Harald Hartweger Anthony P. West Aina E. Cohen Michel C. Nussenzweig Pamela J. Bjorkman
author_sort	Christopher O. Barnes
title	Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope
title_short	Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope
title_full	Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope
title_fullStr	Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope
title_full_unstemmed	Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope
title_sort	structural characterization of a highly-potent v3-glycan broadly neutralizing antibody bound to natively-glycosylated hiv-1 envelope
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7030291af4434b7f82b5c09a827a0481
work_keys_str_mv	AT christopherobarnes structuralcharacterizationofahighlypotentv3glycanbroadlyneutralizingantibodyboundtonativelyglycosylatedhiv1envelope AT harrybgristick structuralcharacterizationofahighlypotentv3glycanbroadlyneutralizingantibodyboundtonativelyglycosylatedhiv1envelope AT nataliatfreund structuralcharacterizationofahighlypotentv3glycanbroadlyneutralizingantibodyboundtonativelyglycosylatedhiv1envelope AT ameliaescolano structuralcharacterizationofahighlypotentv3glycanbroadlyneutralizingantibodyboundtonativelyglycosylatedhiv1envelope AT artemylyubimov structuralcharacterizationofahighlypotentv3glycanbroadlyneutralizingantibodyboundtonativelyglycosylatedhiv1envelope AT haraldhartweger structuralcharacterizationofahighlypotentv3glycanbroadlyneutralizingantibodyboundtonativelyglycosylatedhiv1envelope AT anthonypwest structuralcharacterizationofahighlypotentv3glycanbroadlyneutralizingantibodyboundtonativelyglycosylatedhiv1envelope AT ainaecohen structuralcharacterizationofahighlypotentv3glycanbroadlyneutralizingantibodyboundtonativelyglycosylatedhiv1envelope AT michelcnussenzweig structuralcharacterizationofahighlypotentv3glycanbroadlyneutralizingantibodyboundtonativelyglycosylatedhiv1envelope AT pamelajbjorkman structuralcharacterizationofahighlypotentv3glycanbroadlyneutralizingantibodyboundtonativelyglycosylatedhiv1envelope
_version_	1718386787630448640

Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope

Ejemplares similares