ARC is essential for maintaining pancreatic islet structure and β-cell viability during type 2 diabetes

ARC is essential for maintaining pancreatic islet structure and β-cell viability during type 2 diabetes

Abstract Pancreatic β-cell loss through apoptosis is an important disease mechanism in type 2 diabetes. Apoptosis Repressor with CARD (ARC) is a cell death inhibitor that antagonizes multiple death programs. We previously reported that ARC is abundant in pancreatic β-cells and modulates survival of...

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Autores principales: Wendy M. McKimpson, Min Zheng, Streamson C. Chua, Jeffrey E. Pessin, Richard N. Kitsis
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/7031996fde1a4687baa7bb1020469d40
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