Nocturnal Brain Activity Differs with Age and Sex: Comparisons of Sleep EEG Power Spectra Between Young and Elderly Men, and Between 60–80-Year-Old Men and Women

Torsten Eggert, Hans Dorn, Heidi Danker-Hopfe Charité – Universitätsmedizin Berlin, Competence Centre of Sleep Medicine, Berlin, GermanyCorrespondence: Heidi Danker-Hopfe Email heidi.danker-hopfe@charite.dePurpose: Quantification of nocturnal EEG activity has emerged as a promising extension to the...

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Autores principales: Eggert T, Dorn H, Danker-Hopfe H
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Publicado: Dove Medical Press 2021
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spelling oai:doaj.org-article:703294673a5a4925aee12218e5710f0c2021-12-02T17:44:33ZNocturnal Brain Activity Differs with Age and Sex: Comparisons of Sleep EEG Power Spectra Between Young and Elderly Men, and Between 60–80-Year-Old Men and Women1179-1608https://doaj.org/article/703294673a5a4925aee12218e5710f0c2021-09-01T00:00:00Zhttps://www.dovepress.com/nocturnal-brain-activity-differs-with-age-and-sex-comparisons-of-sleep-peer-reviewed-fulltext-article-NSShttps://doaj.org/toc/1179-1608Torsten Eggert, Hans Dorn, Heidi Danker-Hopfe Charité – Universitätsmedizin Berlin, Competence Centre of Sleep Medicine, Berlin, GermanyCorrespondence: Heidi Danker-Hopfe Email heidi.danker-hopfe@charite.dePurpose: Quantification of nocturnal EEG activity has emerged as a promising extension to the conventional sleep evaluation approach. To date, studies focusing on quantitative sleep EEG data in relation to age and sex have revealed considerable variation across lifespan and differences between men and women. However, sleep EEG power values from elderly individuals are still rare. The present secondary analysis aimed to fill this gap.Participants and Methods: Sleep EEG data of 30 healthy elderly males (mean age ± SD: 69.1 ± 5.5 years), 30 healthy elderly females (67.8 ± 5.7 years), and of 30 healthy young males (25.6 ± 2.4 years) have been collected in three different studies with the same experimental design. Each individual contributed three polysomnographic recordings without any intervention to the analysis. Sleep recordings were performed and evaluated according to the standard of the American Academy of Sleep Medicine. Sleep EEG signals were derived from 19 electrode sites. Sleep-stage specific global and regional EEG power were compared between samples using a permutation-based statistic in combination with the threshold-free cluster enhancement method.Results: The present results showed pronounced differences in sleep EEG power between older men and women. The nocturnal EEG activity of older women was generally larger than that of older men, confirming previously reported variations with sex in younger individuals. Aging was reflected by differences in EEG power between young and elderly men for lower frequencies and for the sleep spindle frequency range, again consistent with prior studies.Conclusion: The findings of this investigation complement those of earlier studies. They add to the understanding of nocturnal brain activity manifestation in senior adulthood and show how it differs with age in males. Unfortunately, the lack of information on young women prevents a similar insight for females.Keywords: neurophysiology, aging, qEEG, gender, topography, TFCEEggert TDorn HDanker-Hopfe HDove Medical PressarticleneurophysiologyagingqeeggendertopographytfcePsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 13, Pp 1611-1630 (2021)
institution DOAJ
collection DOAJ
language EN
topic neurophysiology
aging
qeeg
gender
topography
tfce
Psychiatry
RC435-571
Neurophysiology and neuropsychology
QP351-495
spellingShingle neurophysiology
aging
qeeg
gender
topography
tfce
Psychiatry
RC435-571
Neurophysiology and neuropsychology
QP351-495
Eggert T
Dorn H
Danker-Hopfe H
Nocturnal Brain Activity Differs with Age and Sex: Comparisons of Sleep EEG Power Spectra Between Young and Elderly Men, and Between 60–80-Year-Old Men and Women
description Torsten Eggert, Hans Dorn, Heidi Danker-Hopfe Charité – Universitätsmedizin Berlin, Competence Centre of Sleep Medicine, Berlin, GermanyCorrespondence: Heidi Danker-Hopfe Email heidi.danker-hopfe@charite.dePurpose: Quantification of nocturnal EEG activity has emerged as a promising extension to the conventional sleep evaluation approach. To date, studies focusing on quantitative sleep EEG data in relation to age and sex have revealed considerable variation across lifespan and differences between men and women. However, sleep EEG power values from elderly individuals are still rare. The present secondary analysis aimed to fill this gap.Participants and Methods: Sleep EEG data of 30 healthy elderly males (mean age ± SD: 69.1 ± 5.5 years), 30 healthy elderly females (67.8 ± 5.7 years), and of 30 healthy young males (25.6 ± 2.4 years) have been collected in three different studies with the same experimental design. Each individual contributed three polysomnographic recordings without any intervention to the analysis. Sleep recordings were performed and evaluated according to the standard of the American Academy of Sleep Medicine. Sleep EEG signals were derived from 19 electrode sites. Sleep-stage specific global and regional EEG power were compared between samples using a permutation-based statistic in combination with the threshold-free cluster enhancement method.Results: The present results showed pronounced differences in sleep EEG power between older men and women. The nocturnal EEG activity of older women was generally larger than that of older men, confirming previously reported variations with sex in younger individuals. Aging was reflected by differences in EEG power between young and elderly men for lower frequencies and for the sleep spindle frequency range, again consistent with prior studies.Conclusion: The findings of this investigation complement those of earlier studies. They add to the understanding of nocturnal brain activity manifestation in senior adulthood and show how it differs with age in males. Unfortunately, the lack of information on young women prevents a similar insight for females.Keywords: neurophysiology, aging, qEEG, gender, topography, TFCE
format article
author Eggert T
Dorn H
Danker-Hopfe H
author_facet Eggert T
Dorn H
Danker-Hopfe H
author_sort Eggert T
title Nocturnal Brain Activity Differs with Age and Sex: Comparisons of Sleep EEG Power Spectra Between Young and Elderly Men, and Between 60–80-Year-Old Men and Women
title_short Nocturnal Brain Activity Differs with Age and Sex: Comparisons of Sleep EEG Power Spectra Between Young and Elderly Men, and Between 60–80-Year-Old Men and Women
title_full Nocturnal Brain Activity Differs with Age and Sex: Comparisons of Sleep EEG Power Spectra Between Young and Elderly Men, and Between 60–80-Year-Old Men and Women
title_fullStr Nocturnal Brain Activity Differs with Age and Sex: Comparisons of Sleep EEG Power Spectra Between Young and Elderly Men, and Between 60–80-Year-Old Men and Women
title_full_unstemmed Nocturnal Brain Activity Differs with Age and Sex: Comparisons of Sleep EEG Power Spectra Between Young and Elderly Men, and Between 60–80-Year-Old Men and Women
title_sort nocturnal brain activity differs with age and sex: comparisons of sleep eeg power spectra between young and elderly men, and between 60–80-year-old men and women
publisher Dove Medical Press
publishDate 2021
url https://doaj.org/article/703294673a5a4925aee12218e5710f0c
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