Possible correlation between increased serum free carnitine levels and increased skeletal muscle mass following HCV eradication by direct acting antivirals

Abstract We aimed to evaluate factors associated with changes in skeletal muscle mass in hepatitis C virus (HCV)-infected patients after treatment with direct-acting antivirals (DAAs). Consecutive HCV-infected patients after treatment with DAA were recruited into the study. Patients who achieved sus...

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Autores principales: Yoshimasa Tokuchi, Goki Suda, Megumi Kimura, Osamu Maehara, Takashi Kitagataya, Akinori Kubo, Sonoe Yoshida, Qingjie Fu, Zijian Yang, Shunichi Hosoda, Masatsugu Ohara, Ren Yamada, Kazuharu Suzuki, Naoki Kawagishi, Masato Nakai, Takuya Sho, Mitsuteru Natsuizaka, Kenichi Morikawa, Koji Ogawa, Shunsuke Ohnishi, Naoya Sakamoto
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Publicado: Nature Portfolio 2021
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spelling oai:doaj.org-article:703302c7229a498a89aac76fc46f3e582021-12-02T18:51:47ZPossible correlation between increased serum free carnitine levels and increased skeletal muscle mass following HCV eradication by direct acting antivirals10.1038/s41598-021-96203-z2045-2322https://doaj.org/article/703302c7229a498a89aac76fc46f3e582021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96203-zhttps://doaj.org/toc/2045-2322Abstract We aimed to evaluate factors associated with changes in skeletal muscle mass in hepatitis C virus (HCV)-infected patients after treatment with direct-acting antivirals (DAAs). Consecutive HCV-infected patients after treatment with DAA were recruited into the study. Patients who achieved sustained virological response (SVR); and had complete clinical information, preserved serum samples at baseline and SVR48, and skeletal muscle mass evaluations based on the psoas muscle mass index (PMI) on computed tomography at baseline and ≥ 12 months were included. Altogether, 70.7% of patients (41/58) showed increased PMI after DAA therapy, and mean relative PMI was significantly higher after DAA therapy than at baseline. There were no significant associations between baseline clinical factors routinely examined in clinical practice and increased PMI. Among factors reported to be associated with skeletal muscle loss in patients with chronic liver disease, serum zinc levels and total and free carnitine levels increased significantly after DAA therapy and only changes in serum free carnitine levels were significantly associated with an increased PMI (r = 0305, P = 0.020). In conclusion, increased skeletal muscle mass after successful HCV eradication by DAAs was significantly associated with increased serum-free carnitine levels. l-carnitine supplementation may be beneficial in patients with low skeletal muscle mass after DAA.Yoshimasa TokuchiGoki SudaMegumi KimuraOsamu MaeharaTakashi KitagatayaAkinori KuboSonoe YoshidaQingjie FuZijian YangShunichi HosodaMasatsugu OharaRen YamadaKazuharu SuzukiNaoki KawagishiMasato NakaiTakuya ShoMitsuteru NatsuizakaKenichi MorikawaKoji OgawaShunsuke OhnishiNaoya SakamotoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Yoshimasa Tokuchi
Goki Suda
Megumi Kimura
Osamu Maehara
Takashi Kitagataya
Akinori Kubo
Sonoe Yoshida
Qingjie Fu
Zijian Yang
Shunichi Hosoda
Masatsugu Ohara
Ren Yamada
Kazuharu Suzuki
Naoki Kawagishi
Masato Nakai
Takuya Sho
Mitsuteru Natsuizaka
Kenichi Morikawa
Koji Ogawa
Shunsuke Ohnishi
Naoya Sakamoto
Possible correlation between increased serum free carnitine levels and increased skeletal muscle mass following HCV eradication by direct acting antivirals
description Abstract We aimed to evaluate factors associated with changes in skeletal muscle mass in hepatitis C virus (HCV)-infected patients after treatment with direct-acting antivirals (DAAs). Consecutive HCV-infected patients after treatment with DAA were recruited into the study. Patients who achieved sustained virological response (SVR); and had complete clinical information, preserved serum samples at baseline and SVR48, and skeletal muscle mass evaluations based on the psoas muscle mass index (PMI) on computed tomography at baseline and ≥ 12 months were included. Altogether, 70.7% of patients (41/58) showed increased PMI after DAA therapy, and mean relative PMI was significantly higher after DAA therapy than at baseline. There were no significant associations between baseline clinical factors routinely examined in clinical practice and increased PMI. Among factors reported to be associated with skeletal muscle loss in patients with chronic liver disease, serum zinc levels and total and free carnitine levels increased significantly after DAA therapy and only changes in serum free carnitine levels were significantly associated with an increased PMI (r = 0305, P = 0.020). In conclusion, increased skeletal muscle mass after successful HCV eradication by DAAs was significantly associated with increased serum-free carnitine levels. l-carnitine supplementation may be beneficial in patients with low skeletal muscle mass after DAA.
format article
author Yoshimasa Tokuchi
Goki Suda
Megumi Kimura
Osamu Maehara
Takashi Kitagataya
Akinori Kubo
Sonoe Yoshida
Qingjie Fu
Zijian Yang
Shunichi Hosoda
Masatsugu Ohara
Ren Yamada
Kazuharu Suzuki
Naoki Kawagishi
Masato Nakai
Takuya Sho
Mitsuteru Natsuizaka
Kenichi Morikawa
Koji Ogawa
Shunsuke Ohnishi
Naoya Sakamoto
author_facet Yoshimasa Tokuchi
Goki Suda
Megumi Kimura
Osamu Maehara
Takashi Kitagataya
Akinori Kubo
Sonoe Yoshida
Qingjie Fu
Zijian Yang
Shunichi Hosoda
Masatsugu Ohara
Ren Yamada
Kazuharu Suzuki
Naoki Kawagishi
Masato Nakai
Takuya Sho
Mitsuteru Natsuizaka
Kenichi Morikawa
Koji Ogawa
Shunsuke Ohnishi
Naoya Sakamoto
author_sort Yoshimasa Tokuchi
title Possible correlation between increased serum free carnitine levels and increased skeletal muscle mass following HCV eradication by direct acting antivirals
title_short Possible correlation between increased serum free carnitine levels and increased skeletal muscle mass following HCV eradication by direct acting antivirals
title_full Possible correlation between increased serum free carnitine levels and increased skeletal muscle mass following HCV eradication by direct acting antivirals
title_fullStr Possible correlation between increased serum free carnitine levels and increased skeletal muscle mass following HCV eradication by direct acting antivirals
title_full_unstemmed Possible correlation between increased serum free carnitine levels and increased skeletal muscle mass following HCV eradication by direct acting antivirals
title_sort possible correlation between increased serum free carnitine levels and increased skeletal muscle mass following hcv eradication by direct acting antivirals
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/703302c7229a498a89aac76fc46f3e58
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