Evaluation of social and physical enrichment in modulation of behavioural phenotype in C57BL/6J female mice.

Housing conditions represent an important environmental variable playing a critical role in the assessment of mouse behaviour. In the present study the effects of isolation and nesting material on the behaviour of female C57BL/6J mice were evaluated. The mice were subjected to different rearing cond...

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Autores principales:	Natalia Kulesskaya, Heikki Rauvala, Vootele Voikar
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/70357442d2d94de89eebbe180d96ebe3
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spelling	oai:doaj.org-article:70357442d2d94de89eebbe180d96ebe32021-11-04T06:08:58ZEvaluation of social and physical enrichment in modulation of behavioural phenotype in C57BL/6J female mice.1932-620310.1371/journal.pone.0024755https://doaj.org/article/70357442d2d94de89eebbe180d96ebe32011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21931844/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Housing conditions represent an important environmental variable playing a critical role in the assessment of mouse behaviour. In the present study the effects of isolation and nesting material on the behaviour of female C57BL/6J mice were evaluated. The mice were subjected to different rearing conditions from weaning (at the age of 3 weeks). The study groups were group- and single-housed mice, divided further into groups with or without nesting material (species-specific enrichment). After 8 weeks spent in respective conditions the behavioural testing began. Both factors (social conditions and nesting material) appeared to have a significant impact on the behavioural phenotype. However, it is important to stress that the interaction between the factors was virtually absent. We established that isolation increased locomotor activity and reduced anxiety-like behaviour in several tests of exploration. In contrast, absence of nesting material increased anxiety-like behaviour. Neither factor affected rota-rod performance, nociception and prepulse inhibition. Contextual fear memory was significantly reduced in single-housed mice, and interestingly, in mice with nesting material. Cued fear memory was reduced by single-housing, but not affected by enrichment. Mice from enriched cages displayed faster and better learning and spatial search strategy in the water maze. In contrast, isolation caused significant impairment in the water maze. In conclusion, both isolation and species-specific enrichment have profound effects on mouse behaviour and should be considered in design of the experiments and in assessment of animal welfare issues.Natalia KulesskayaHeikki RauvalaVootele VoikarPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e24755 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Natalia Kulesskaya Heikki Rauvala Vootele Voikar Evaluation of social and physical enrichment in modulation of behavioural phenotype in C57BL/6J female mice.
description	Housing conditions represent an important environmental variable playing a critical role in the assessment of mouse behaviour. In the present study the effects of isolation and nesting material on the behaviour of female C57BL/6J mice were evaluated. The mice were subjected to different rearing conditions from weaning (at the age of 3 weeks). The study groups were group- and single-housed mice, divided further into groups with or without nesting material (species-specific enrichment). After 8 weeks spent in respective conditions the behavioural testing began. Both factors (social conditions and nesting material) appeared to have a significant impact on the behavioural phenotype. However, it is important to stress that the interaction between the factors was virtually absent. We established that isolation increased locomotor activity and reduced anxiety-like behaviour in several tests of exploration. In contrast, absence of nesting material increased anxiety-like behaviour. Neither factor affected rota-rod performance, nociception and prepulse inhibition. Contextual fear memory was significantly reduced in single-housed mice, and interestingly, in mice with nesting material. Cued fear memory was reduced by single-housing, but not affected by enrichment. Mice from enriched cages displayed faster and better learning and spatial search strategy in the water maze. In contrast, isolation caused significant impairment in the water maze. In conclusion, both isolation and species-specific enrichment have profound effects on mouse behaviour and should be considered in design of the experiments and in assessment of animal welfare issues.
format	article
author	Natalia Kulesskaya Heikki Rauvala Vootele Voikar
author_facet	Natalia Kulesskaya Heikki Rauvala Vootele Voikar
author_sort	Natalia Kulesskaya
title	Evaluation of social and physical enrichment in modulation of behavioural phenotype in C57BL/6J female mice.
title_short	Evaluation of social and physical enrichment in modulation of behavioural phenotype in C57BL/6J female mice.
title_full	Evaluation of social and physical enrichment in modulation of behavioural phenotype in C57BL/6J female mice.
title_fullStr	Evaluation of social and physical enrichment in modulation of behavioural phenotype in C57BL/6J female mice.
title_full_unstemmed	Evaluation of social and physical enrichment in modulation of behavioural phenotype in C57BL/6J female mice.
title_sort	evaluation of social and physical enrichment in modulation of behavioural phenotype in c57bl/6j female mice.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/70357442d2d94de89eebbe180d96ebe3
work_keys_str_mv	AT nataliakulesskaya evaluationofsocialandphysicalenrichmentinmodulationofbehaviouralphenotypeinc57bl6jfemalemice AT heikkirauvala evaluationofsocialandphysicalenrichmentinmodulationofbehaviouralphenotypeinc57bl6jfemalemice AT vootelevoikar evaluationofsocialandphysicalenrichmentinmodulationofbehaviouralphenotypeinc57bl6jfemalemice
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Evaluation of social and physical enrichment in modulation of behavioural phenotype in C57BL/6J female mice.

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