The Role of Perivascular Adipose Tissue in Early Changes in Arterial Function during High-Fat Diet and Its Combination with High-Fructose Intake in Rats

The aim of the current study was to evaluate the influence of a high-fat diet and its combination with high-fructose intake on young normotensive rats, with focus on the modulatory effect of perivascular adipose tissue (PVAT) on the reactivity of isolated arteries. Six-week-old Wistar–Kyoto rats wer...

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Autores principales:	Jozef Torok, Anna Zemancikova, Zuzana Valaskova, Peter Balis
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	arteries perivascular adipose tissue high-fat diet high-fructose intake neurogenic contraction Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/703c61e7f7984fd59ed304fe66fb3809
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spelling	oai:doaj.org-article:703c61e7f7984fd59ed304fe66fb38092021-11-25T16:48:56ZThe Role of Perivascular Adipose Tissue in Early Changes in Arterial Function during High-Fat Diet and Its Combination with High-Fructose Intake in Rats10.3390/biomedicines91115522227-9059https://doaj.org/article/703c61e7f7984fd59ed304fe66fb38092021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1552https://doaj.org/toc/2227-9059The aim of the current study was to evaluate the influence of a high-fat diet and its combination with high-fructose intake on young normotensive rats, with focus on the modulatory effect of perivascular adipose tissue (PVAT) on the reactivity of isolated arteries. Six-week-old Wistar–Kyoto rats were treated for 8 weeks with a control diet (10% fat), a high-fat diet (HFD; 45% fat), or a combination of the HFD with a 10% solution of fructose. Contractile and relaxant responses of isolated rat arteries, with preserved and removed PVAT for selected vasoactive stimuli, were recorded isometrically by a force displacement transducer. The results demonstrated that, in young rats, eight weeks of the HFD might lead to body fat accumulation and early excitation of the cardiovascular sympathetic nervous system, as shown by increased heart rate and enhanced arterial contractile responses induced by endogenous noradrenaline released from perivascular sympathetic nerves. The addition of high-fructose intake deteriorated this state by impairment of arterial relaxation and resulted in mild elevation of systolic blood pressure; however, the increase in arterial neurogenic contractions was not detected. The diet-induced alterations in isolated arteries were observed only in the presence of PVAT, indicating that this structure is important in initiation of early vascular changes during the development of metabolic syndrome.Jozef TorokAnna ZemancikovaZuzana ValaskovaPeter BalisMDPI AGarticlearteriesperivascular adipose tissuehigh-fat diethigh-fructose intakeneurogenic contractionBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1552, p 1552 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	arteries perivascular adipose tissue high-fat diet high-fructose intake neurogenic contraction Biology (General) QH301-705.5
spellingShingle	arteries perivascular adipose tissue high-fat diet high-fructose intake neurogenic contraction Biology (General) QH301-705.5 Jozef Torok Anna Zemancikova Zuzana Valaskova Peter Balis The Role of Perivascular Adipose Tissue in Early Changes in Arterial Function during High-Fat Diet and Its Combination with High-Fructose Intake in Rats
description	The aim of the current study was to evaluate the influence of a high-fat diet and its combination with high-fructose intake on young normotensive rats, with focus on the modulatory effect of perivascular adipose tissue (PVAT) on the reactivity of isolated arteries. Six-week-old Wistar–Kyoto rats were treated for 8 weeks with a control diet (10% fat), a high-fat diet (HFD; 45% fat), or a combination of the HFD with a 10% solution of fructose. Contractile and relaxant responses of isolated rat arteries, with preserved and removed PVAT for selected vasoactive stimuli, were recorded isometrically by a force displacement transducer. The results demonstrated that, in young rats, eight weeks of the HFD might lead to body fat accumulation and early excitation of the cardiovascular sympathetic nervous system, as shown by increased heart rate and enhanced arterial contractile responses induced by endogenous noradrenaline released from perivascular sympathetic nerves. The addition of high-fructose intake deteriorated this state by impairment of arterial relaxation and resulted in mild elevation of systolic blood pressure; however, the increase in arterial neurogenic contractions was not detected. The diet-induced alterations in isolated arteries were observed only in the presence of PVAT, indicating that this structure is important in initiation of early vascular changes during the development of metabolic syndrome.
format	article
author	Jozef Torok Anna Zemancikova Zuzana Valaskova Peter Balis
author_facet	Jozef Torok Anna Zemancikova Zuzana Valaskova Peter Balis
author_sort	Jozef Torok
title	The Role of Perivascular Adipose Tissue in Early Changes in Arterial Function during High-Fat Diet and Its Combination with High-Fructose Intake in Rats
title_short	The Role of Perivascular Adipose Tissue in Early Changes in Arterial Function during High-Fat Diet and Its Combination with High-Fructose Intake in Rats
title_full	The Role of Perivascular Adipose Tissue in Early Changes in Arterial Function during High-Fat Diet and Its Combination with High-Fructose Intake in Rats
title_fullStr	The Role of Perivascular Adipose Tissue in Early Changes in Arterial Function during High-Fat Diet and Its Combination with High-Fructose Intake in Rats
title_full_unstemmed	The Role of Perivascular Adipose Tissue in Early Changes in Arterial Function during High-Fat Diet and Its Combination with High-Fructose Intake in Rats
title_sort	role of perivascular adipose tissue in early changes in arterial function during high-fat diet and its combination with high-fructose intake in rats
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/703c61e7f7984fd59ed304fe66fb3809
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The Role of Perivascular Adipose Tissue in Early Changes in Arterial Function during High-Fat Diet and Its Combination with High-Fructose Intake in Rats

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